Het-PDB Navi2 (PDB: 1AD1)

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Ligands
Code	Name		Style	Show	Link
K	Potassium ion				PoSSuM
TRS	2-amino-2-hydroxymethyl-propane-1,3-diol				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1AD1

Code :

1AD1 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

DIHYDROPTEROATE SYNTHETASE (APO FORM) FROM STAPHYLOCOCCUS AUREUS

Release Data :

1998-04-29

Compound :

mol_id	molecule	chains	synonym
1	DIHYDROPTEROATE SYNTHETASE	A,B	DHPS
	ec: 2.5.1.15 other_details: APO FORM

Source :

mol_id	organism_scientific
1	Staphylococcus aureus (taxid:1280)

Authors :

Kostrewa, D., Oefner, C., D'Arcy, A.

Keywords :

SYNTHETASE, TRANSFERASE, DIHYDROPTEROATE SYNTHETASE, DHPS, APO FORM, COMPLEX WITH OH-CH2-PTERIN-PYROPHOSPHATE

Exp. method :

X-RAY DIFFRACTION ( 2.2 Å )

Citation :

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

Hampele, I.C.,D'Arcy, A.,Dale, G.E. et al.
(1997) J.Mol.Biol. 268 : 21 - 30

Chain :

A, B

UniProt :

O05701 (DHPS_STAAU)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate	2.5.1.15	PubMed:9149138
	-	PubMed:9149138
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000250 \| UniProtKB:P0AC13 ECO:0000305 \| PubMed:9149138	Magnesium is required for activity, even if it seems to interact primarily with the substrate.

PDB ID: 1AD1