Brand  (β version)

PDB ID: 1ABN

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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1ABN   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : THE CRYSTAL STRUCTURE OF THE ALDOSE REDUCTASE NADPH BINARY COMPLEX
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALDOSE REDUCTASE A
ec: 1.1.1.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Borhani, D.W., Harter, T.M., Petrash, J.M.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

The crystal structure of the aldose reductase.NADPH binary complex.

Borhani, D.W.,Harter, T.M.,Petrash, J.M.
(1992)  J.Biol.Chem.  267 : 24841 - 24847

PubMed: 1447221

Probing the Active Site of Aldose Reductase: Site-Directed Mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110

Tarle, I.,Borhani, D.W.,Wilson, D.K.  et al.
To be Published 

Studies on Pig Aldose Reductase: Identification of an Essential Arginine in the Primary and Tertiary Structure of the Enzyme

Kubiseski, T.J.,Green, N.C.,Borhani, D.W.  et al.
To be Published 

Kinetic Alteration of Human Aldose Reductase by Mutagenesis of Cysteine Residues

Petrash, J.M.,Harter, T.,Tarle, I.  et al.
(1993)  Adv.Exp.Med.Biol.  328 : 289

Involvement of Cysteine Residues in Catalysis and Inhibition of Human Aldose Reductase: Site Directed Mutagenesis of Cys-80,-298 and-303

Petrash, J.M.,Harter, T.M.,Devine, C.S.  et al.
(1992)  J.Biol.Chem.  267 : 24833

Reaction

Chain : A
UniProt : P15121 (ALDR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
an alditol + NADP(+) = an aldose + H(+) + NADPH 1.1.1.21 PubMed:8245005
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all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH 1.1.1.300 PubMed:12732097, PubMed:21329680
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9-cis-retinol + NADP(+) = 9-cis-retinal + H(+) + NADPH - PubMed:12732097, PubMed:21329680
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13-cis-retinol + NADP(+) = 13-cis-retinal + H(+) + NADPH - PubMed:12732097
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glycerol + NADP(+) = D-glyceraldehyde + H(+) + NADPH 1.1.1.372 PubMed:10510318, PubMed:12732097, PubMed:1936586, PubMed:21329680, PubMed:8245005
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glycerol + NADP(+) = H(+) + L-glyceraldehyde + NADPH 1.1.1.372 PubMed:10510318, PubMed:12732097, PubMed:1936586, PubMed:21329680, PubMed:8245005
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NADP(+) + prenol = 3-methyl-2-butenal + H(+) + NADPH - PubMed:21329684
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(E)-hex-2-en-1-ol + NADP(+) = (E)-hex-2-enal + H(+) + NADPH - PubMed:21329684
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(E,E)-2,4-hexadien-1-ol + NADP(+) = (E,E)-2,4-hexadienal + H(+) + NADPH - PubMed:21329684
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a 4-hydroxynonen-1-ol + NADP(+) = a 4-hydroxynonenal + H(+) + NADPH - PubMed:21329684
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NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2 - PubMed:19010934
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allyl alcohol + NADP(+) = acrolein + H(+) + NADPH 1.1.1.54 PubMed:10510318, PubMed:21329684
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NADP(+) + pyridine 3-methanol = H(+) + NADPH + pyridine-3- carbaldehyde - PubMed:12732097
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1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3- phosphocholine + NADP(+) - PubMed:17381426
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1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3- phosphocholine + NADP(+) - PubMed:17381426
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1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H(+) + NADPH = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3- phosphocholine + NADP(+) - PubMed:17381426
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1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3- phosphoethanolamine + H(+) + NADPH = 1-hexadecanoyl-2-(5- hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+) - PubMed:17381426
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