Brand  (β version)

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hetatm:

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information
centroid:
interaction residue:

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Ligands
Code Name Link
0G6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Code : 1ABJ
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 ALPHA-THROMBIN (SMALL SUBUNIT) L
ec: 3.4.21.5
mol_id molecule chains
2 ALPHA-THROMBIN (LARGE SUBUNIT) H
ec: 3.4.21.5
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
organ: PLASMA
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
organ: PLASMA
Authors : Qiu, X., Tulinsky, A.
Keywords : SERINE PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.

Qiu, X.,Padmanabhan, K.P.,Carperos, V.E.  et al.
(1992)  Biochemistry  31 : 11689 - 11697

PubMed: 1445905
DOI: 10.1021/bi00162a004

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.,Ravichandran, K.G.  et al.
(1991)  J.Mol.Biol.  221 : 1379

The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin

Rydel, T.J.,Ravichandran, K.G.,Tulinsky, A.  et al.
(1990)  Science  249 : 277

The Refined 1.9 Angstroms Crystal Structure of Human Alpha-Thrombin: Interaction with D-Phe-Pro-Arg Chloromethylketone and Significance of the Tyr-Pro-Pro-Trp Insertion Segment

Bode, W.,Mayr, I.,Baumann, U.  et al.
(1989)  Embo J.  8 : 3467

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction : Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.