Het-PDB Navi2 (PDB: 1ABI)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
DPN	D-phenylalanine
HMR	Beta-homoarginine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1ABI

Code :

1ABI PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

STRUCTURE OF THE HIRULOG 3-THROMBIN COMPLEX AND NATURE OF THE S' SUBSITES OF SUBSTRATES AND INHIBITORS

Release Data :

1994-01-31

Compound :

mol_id	molecule	chains
1	ALPHA-THROMBIN (SMALL SUBUNIT)	L
	ec: 3.4.21.5

mol_id	molecule	chains
2	ALPHA-THROMBIN (LARGE SUBUNIT)	H
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRULOG 3	I

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	organ: PLASMA

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	organ: PLASMA

mol_id	organism_scientific	organism_common
3	Hirudo medicinalis (taxid:6421)	Medicinal leech

Authors :

Qiu, X., Tulinsky, A.

Keywords :

HYDROLASE(SERINE PROTEINASE), HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.

Qiu, X.,Padmanabhan, K.P.,Carperos, V.E. et al.
(1992) Biochemistry 31 : 11689 - 11697

PubMed: 1445905
DOI: 10.1021/bi00162a004

Structure of the Hirugen and Hirulog 1 Complexes of Alpha-Thrombin

Skrzypczak-Jankun, E.,Carperos, V.,Ravichandran, K.G. et al.
(1991) J.Mol.Biol. 221 : 1379

The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin

Rydel, T.J.,Ravichandran, K.G.,Tulinsky, A. et al.
(1990) Science 249 : 277

The Refined 1.9 Angstroms Crystal Structure of Human Alpha-Thrombin: Interaction with D-Phe-Pro-Arg Chloromethylketone and Significance of the Tyr-Pro-Pro-Trp Insertion Segment

Bode, W.,Mayr, I.,Baumann, U. et al.
(1989) Embo J. 8 : 3467

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

Chain :	I
UniProt :	P28504 (HIR2_HIRME)
Reaction :	-

PDB ID: 1ABI

Hetero Atom Contents

Structure summary

Reaction