Brand  (β version)

PDB ID: 1A9C

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Ligands
Code Name Style Show Link
GTP Guanosine-5'-triphosphate PoSSuM
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Glycosylation
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Structure summary

Code : 1A9C   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : GTP CYCLOHYDROLASE I (C110S MUTANT) IN COMPLEX WITH GTP
Release Data : 1999-05-11
Compound :
mol_id molecule chains
1 GTP CYCLOHYDROLASE I A,B,C,D,E,F,G,H,I,J,K,L,M,N,O
ec: 3.5.4.16
mutation: C110S
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
organ: BRAIN
other_details: HOMOLOGOUS EXPRESSION
Authors : Auerbach, G., Nar, H., Bracher, A., Bacher, A., Huber, R.
Keywords : HYDROLASE, GTP, PURINE HYDROLYSIS, PTERINE SYNTHESIS, TETRAHYDROBIOPTERIN
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

GTP Cyclohydrolase I in Complex with GTP at 2.1 A Resolution

Auerbach, G.,Bracher, A.,Nar, H.  et al.
To be Published 

The Pathway from GTP to Tetrahydrobiopterin: Three-Dimensional Structures of GTP Cyclohydrolase I and 6-Pyruvoyl Tetrahydropterin Synthase

Auerbach, G.,Nar, H.
(1997)  Biol.Chem.  378 : 185

The 1.25 A Crystal Structure of Sepiapterin Reductase Reveals its Binding Mode to Pterins and Brain Neurotransmitters

Auerbach, G.,Herrmann, A.,Gutlich, M.  et al.
(1997)  Embo J.  16 : 7219

Active Site Topology and Reaction Mechanism of GTP Cyclohydrolase I

Nar, H.,Huber, R.,Auerbach, G.  et al.
(1995)  Proc.Natl.Acad.Sci.USA  92 : 12120

Atomic Structure of GTP Cyclohydrolase I

Nar, H.,Huber, R.,Meining, W.  et al.
(1995)  Structure  3 : 459

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L, M, N, O
UniProt : P0A6T5 (GCH1_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+) 3.5.4.16 -
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