Brand  (β version)

PDB ID: 1A97

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Ligands
Code Name Style Show Link
5GP Guanosine-5'-monophosphate PoSSuM
BO3 Boric acid PoSSuM
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Structure summary

Code : 1A97   PDBj   RCSB PDB   PDBe
Header : PHOSPHORIBOSYLTRANSFERASE
Title : XPRTASE FROM E. COLI COMPLEXED WITH GMP
Release Data : 1998-11-11
Compound :
mol_id molecule chains synonym
1 XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE A,B,C,D XPRT
ec: 2.4.2.22
mutation: C59A
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
strain: HB101
atcc: ATCC 37145
cellular_location: CYTOPLASM
gene: GPT
expression_system_strain: SPHI606
expression_system_cellular_location: CYTOPLASM
expression_system_plasmid: PT7-7
expression_system_gene: GPT
Authors : Vos, S., Parry, R.J., Burns, M.R., De Jersey, J., Martin, J.L.
Keywords : PHOSPHORIBOSYLTRANSFERASE, TRANSFERASE, PURINE SALVAGE ENZYME, GLYCOSYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase.

Vos, S.,Parry, R.J.,Burns, M.R.  et al.
(1998)  J.Mol.Biol.  282 : 875 - 889

PubMed: 9743633
DOI: 10.1006/jmbi.1998.2051

Reaction

Chain : A, B, C, D
UniProt : P0A9M5 (XGPT_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine - PubMed:3886014, PubMed:9100006
right-to-left PubMed:9100006
diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine 2.4.2.22 PubMed:3886014, PubMed:9100006
right-to-left PubMed:9100006
diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine - PubMed:3886014, PubMed:9100006
right-to-left PubMed:9100006