Brand  (β version)

PDB ID: 1A8T

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
061 2-butyl-6-hydroxy-3-[2'-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-quinazolin-4-one PoSSuM
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Structure summary

Code : 1A8T   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : METALLO-BETA-LACTAMASE IN COMPLEX WITH L-159,061
Release Data : 1998-10-14
Compound :
mol_id molecule chains synonym
1 METALLO-BETA-LACTAMASE A,B CLASS B BETA-LACTAMASE
ec: 3.5.2.6
mutation: A171T, D208N
Source :
mol_id organism_scientific expression_system
1 Bacteroides fragilis  (taxid:817) Escherichia coli  (taxid:562)
strain: TAL3636
variant: CLINICAL ISOLATE
gene: CCRA
Authors : Fitzgerald, P.M.D., Toney, J.H., Grover, N., Vanderwall, D.
Keywords : HYDROLASE, BETA-LACTAMASE, METALLO-BETA-LACTAMASE, ZINC, ANTIBIOTIC RESISTANCE
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase.

Toney, J.H.,Fitzgerald, P.M.,Grover-Sharma, N.  et al.
(1998)  Chem.Biol.  5 : 185 - 196

PubMed: 9545432
DOI: 10.1016/S1074-5521(98)90632-9

Unanticipated Inhibition of the Metallo-Beta-Lactamase from Bacteroides Fragilis by 4-Morpholineethanesulfonic Acid (Mes): A Crystallographic Study at 1.85-A Resolution

Fitzgerald, P.M.,Wu, J.K.,Toney, J.H.
(1998)  Biochemistry  37 : 6791

High-Yield Expression, Purification, and Characterization of Active, Soluble Bacteroides Fragilis Metallo-Beta-Lactamase, Ccra

Toney, J.H.,Wu, J.K.,Overbye, K.M.  et al.
(1997)  Protein Expr.Purif.  9 : 355

Reaction

Chain : A, B
UniProt : P25910 (BLAB_BACFG)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:9712862
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