Brand  (β version)

PDB ID: 1A8O

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Ligands
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Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Modification
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Structure summary

Code : 1A8O   PDBj   RCSB PDB   PDBe
Header : VIRAL PROTEIN
Title : HIV CAPSID C-TERMINAL DOMAIN
Release Data : 1998-10-14
Compound :
mol_id molecule chains
1 HIV CAPSID A
fragment: C-TERMINAL DOMAIN, RESIDUES 151 - 231
mutation: SELENOMETHIONINE SUBSTITUTIONS, L151MSE, M185MSE, M214MSE, M215MSE
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli BL21(DE3)  (taxid:469008)
cell_line: BL21
expression_system_strain: BL21 (DE3)
expression_system_vector: PET11A
expression_system_plasmid: WISP97-7
Authors : Gamble, T.R., Yoo, S., Vajdos, F.F., Von Schwedler, U.K., Worthylake, D.K., Wang, H., Mccutcheon, J.P., Sundquist, W.I., Hill, C.P.
Keywords : CAPSID, CORE PROTEIN, HIV, C-TERMINAL DOMAIN, Viral protein
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

Gamble, T.R.,Yoo, S.,Vajdos, F.F.  et al.
(1997)  Science  278 : 849 - 853

PubMed: 9346481
DOI: 10.1126/science.278.5339.849

Reaction

Chain : A
UniProt : P12497 (POL_HV1N5)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 ECO:0000250
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 ECO:0000250
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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