Brand  (β version)

PDB ID: 1A8I

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Ligands
Code Name Style Show Link
GLS Beta-D-glucopyranose spirohydantoin PoSSuM
Non-standard Residues
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LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Modification
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Structure summary

Code : 1A8I   PDBj   RCSB PDB   PDBe
Header : GLYCOGEN PHOSPHORYLASE
Title : SPIROHYDANTOIN INHIBITOR OF GLYCOGEN PHOSPHORYLASE
Release Data : 1998-07-01
Compound :
mol_id molecule chains
1 GLYCOGEN PHOSPHORYLASE B A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Gregoriou, M., Noble, M.E.M., Watson, K.A., Garman, E.F., Krulle, T.M., De La Fuente, C., Fleet, G.W.J., Oikonomakos, N.G., Johnson, L.N.
Keywords : GLYCOGEN PHOSPHORYLASE, GLUCOPYRANOSE SPIROHYDANTOIN, WATER STRUCTURE, INHIBITOR BINDING, ANTI-HYPERGLYCEMIC AGENT
Exp. method : X-RAY DIFFRACTION ( 1.78 Å )
Citation :

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 A resolution and 100 K: the role of the water structure and its contribution to binding.

Gregoriou, M.,Noble, M.E.,Watson, K.A.  et al.
(1998)  Protein Sci.  7 : 915 - 927

PubMed: 9568898

Stereospecific Synthesis of Spirohydantoins of Beta-Glucopyranose: Inhibitors of Glycogen Phosphorylase

Krulle, T.M.,De La Fuente, C.,Watson, K.A.  et al.
(1997)  Synlett  : 211

Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin

Bichard, C.J.F.,Mitchell, E.P.,Wormald, M.R.  et al.
(1995)  Tetrahedron Lett.  36 : 2145

Design of Inhibitors of Glycogen Phosphorylase: A Study of Alpha-and Beta-C-Glucosides and 1-Thio-Beta-D-Glucose Compounds

Watson, K.A.,Mitchell, E.P.,Johnson, L.N.  et al.
(1994)  Biochemistry  33 : 5745

Glucose Analogue Inhibitors of Glycogen Phosphorylase: The Design of Potential Drugs for Diabetes

Martin, J.L.,Veluraja, K.,Ross, K.  et al.
(1991)  Biochemistry  30 : 10101

?

Acharya, K.R.,Stuart, D.I.,Varvill, K.M.  et al.
(1991)  Glycogen Phosphorylase B: Description of the Protein Structure 

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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