Brand  (β version)

PDB ID: 1A86

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Ligands
Code Name Style Show Link
0ZB N-benzyl-N~2~-[(2r)-2-(hydroxycarbamoyl)-4-methylpentanoyl]-L-alpha-asparagine PoSSuM
CA Calcium ion PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1A86   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : MMP8 WITH MALONIC AND ASPARTIC ACID BASED INHIBITOR
Release Data : 1999-05-04
Compound :
mol_id molecule chains
1 MMP-8 A
ec: 3.4.24.34
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
Authors : Brandstetter, H., Roedern, E.G.V., Grams, F., Engh, R.A.
Keywords : COLLAGENASE, MATRIX METALLOPROTEINASE, MALONIC ACID, MMP8, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data.

Brandstetter, H.,Engh, R.A.,Von Roedern, E.G.  et al.
(1998)  Protein Sci.  7 : 1303 - 1309

PubMed: 9655333

Reaction

Chain : A
UniProt : P22894 (MMP8_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I. 3.4.24.34 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 3 Ca(2+) ions per subunit.
Zn(2+) - Binds 2 Zn(2+) ions per subunit.