Het-PDB Navi2 (PDB: 1A82)

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Ligands
Code	Name	Link
ATP	Adenosine-5'-triphosphate	PoSSuM
DNN	7,8-diamino-nonanoic acid	PoSSuM
MG	Magnesium ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1A82

Code :

1A82 PDBj RCSB PDB PDBe

Header :

BIOTIN BIOSYNTHESIS

Title :

DETHIOBIOTIN SYNTHETASE FROM ESCHERICHIA COLI, COMPLEX WITH SUBSTRATES ATP AND DIAMINOPELARGONIC ACID

Release Data :

1999-05-11

Compound :

mol_id	molecule	chains
1	DETHIOBIOTIN SYNTHETASE	A
	ec: 6.3.3.3

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	cellular_location: CYTOPLASM expression_system_cellular_location: CYTOPLASM expression_system_vector_type: PLASMID expression_system_gene: BIOD

Authors :

Kaeck, H., Gibson, K.J., Lindqvist, Y., Schneider, G.

Keywords :

PHOSPHORYL TRANSFER, BIOTIN BIOSYNTHESIS, LIGASE

Exp. method :

X-RAY DIFFRACTION ( 1.8 Å )

Citation :

Snapshot of a phosphorylated substrate intermediate by kinetic crystallography.

Kack, H.,Gibson, K.J.,Lindqvist, Y. et al.
(1998) Proc.Natl.Acad.Sci.USA 95 : 5495 - 5500

Chain :

UniProt :

P13000 (BIOD1_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)- dethiobiotin + ADP + phosphate + 3 H(+)	6.3.3.3	HAMAP-Rule:MF_00336, PubMed:4921568
	-	HAMAP-Rule:MF_00336, PubMed:4921568
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000255 \| HAMAP-Rule:MF_00336 ECO:0000269 \| PubMed:7669756 ECO:0000269 \| PubMed:7881906 ECO:0000269 \| PubMed:9576910 ECO:0000269 \| PubMed:9865950	Binds 1 Mg(2+) per subunit, in one structure a second Mg(2+) was seen.

PDB ID: 1A82