Het-PDB Navi2 (PDB: 1A81)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
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Download interaction data: 1A81

Code :

1A81 PDBj RCSB PDB PDBe

Header :

COMPLEX (TRANSFERASE/PEPTIDE)

Title :

CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM

Release Data :

1998-10-21

Compound :

mol_id	molecule	chains
1	SYK KINASE	A,C,E,G,I,K
	ec: 2.7.1.112 fragment: TANDEM SH2 DOMAIN

mol_id	molecule	chains	synonym
2	T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN	B,D,F,H,J,L	ITAM PEPTIDE

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: SYK expression_system_strain: DH5 ALPHA expression_system_plasmid: PGEX

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Fuetterer, K., Waksman, G.

Keywords :

COMPLEX (TRANSFERASE-PEPTIDE), SYK, KINASE, SH2 DOMAIN, ITAM, COMPLEX (TRANSFERASE-PEPTIDE) complex

Exp. method :

X-RAY DIFFRACTION ( 3.0 Å )

Citation :

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

Futterer, K.,Wong, J.,Grucza, R.A. et al.
(1998) J.Mol.Biol. 281 : 523 - 537

PubMed: 9698567
DOI: 10.1006/jmbi.1998.1964

Chain :	B, D, F, H, J, L
UniProt :	P07766 (CD3E_HUMAN)
Reaction :	-

PDB ID: 1A81

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