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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate
Non-standard Residues
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Glycosylation
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Code : 1A80   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Native 2,5-DIKETO-D-GLUCONIC acid reductase a from CORYNBACTERIUM SP. complexed with NADPH
Release Data : 1999-03-30
Compound :
mol_id molecule chains synonym
1 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE A A 2,5-DKG REDUCTASE A
Source :
mol_id organism_scientific expression_system
1 Corynebacterium sp.  (taxid:1720) Pantoea citrea  (taxid:53336)
variant: A
gene: 2 5-DIKETO-D-GLUCONIC ACID
expression_system_strain: IFO3263
expression_system_plasmid: PTRP1-35
expression_system_gene: 2 5-DIKETO-D-GLUCONIC ACID
Authors : Khurana, S., Powers, D.B., Anderson, S., Blaber, M.
Keywords : OXIDOREDUCTASE, ALPHA8/BETA8 BARREL, 2, 5-DIKETO-D-GLUCONIC ACID, COMMERCIAL VITAMIN C SYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of 2,5-diketo-D-gluconic acid reductase A complexed with NADPH at 2.1-A resolution.

Khurana, S.,Powers, D.B.,Anderson, S.  et al.
(1998)  Proc.Natl.Acad.Sci.USA  95 : 6768 - 6773

PubMed: 9618487
DOI: 10.1073/pnas.95.12.6768

Comparative Anatomy of the Aldo-Keto Reductase Superfamily

Jez, J.M.,Bennett, M.J.,Schlegel, B.P.  et al.
(1997)  Biochem.J.  326 : 625

Production of 2-Keto-L-Gulonate, an Intermediate in L-Ascorbate Synthesis, by a Genetically Modified Erwinia Herbicola

Anderson, S.,Marks, C.B.,Lazarus, R.  et al.
(1985)  Science  230 : 144

Chain : A
UniProt : P06632 (DKGA_CORSC)
Reaction: EC: Evidence:
Physiological Direction:
2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + H(+) + NADPH 1.1.1.346 -
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