Brand  (β version)

PDB ID: 1A7K

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Ligands
Code Name Style Show Link
NAD Nicotinamide-adenine-dinucleotide PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1A7K   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN A MONOCLINIC CRYSTAL FORM
Release Data : 1998-06-17
Compound :
mol_id molecule chains synonym
1 GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A,B,C,D GAPDH
ec: 1.2.1.12
other_details: ONE BOUND NAD AND TWO BOUND PHOSPHATES PER MONOMER
Source :
mol_id organism_scientific expression_system
1 Leishmania mexicana  (taxid:5665) Escherichia coli  (taxid:562)
cell_line: BL21
expression_system_strain: BL21 PLYSS
expression_system_plasmid: PET-3A
Authors : Kim, H., Hol, W.G.J.
Keywords : GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, GLYCOSOME, TRYPANOSOME, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure.

Kim, H.,Hol, W.G.
(1998)  J.Mol.Biol.  278 : 5 - 11

PubMed: 9571030
DOI: 10.1006/jmbi.1998.1661

Crystal Structure of Glycosomal Glyceraldehyde-3-Phosphate Dehydrogenase from Leishmania Mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding Site

Kim, H.,Feil, I.K.,Verlinde, C.L.  et al.
(1995)  Biochemistry  34 : 14975

Reaction

Chain : A, B, C, D
UniProt : Q27890 (G3PG_LEIME)
Reaction: EC: Evidence:
Physiological Direction:
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3- phospho-glyceroyl phosphate + NADH + H(+) 1.2.1.12 PROSITE-ProRule:PRU10009
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