Brand  (β version)

PDB ID: 1A7C

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
RIP Beta-D-ribopyranose
Modification
Code Name Show
ACE Acetyl group
NH2 Amino group

Structure summary

Code : 1A7C   PDBj   RCSB PDB   PDBe
Header : HYDROLASE INHIBITOR/PEPTIDE
Title : HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE
Release Data : 1999-03-23
Compound :
mol_id molecule chains synonym
1 PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 A PAI-1
mutation: A335E
mol_id molecule chains
2 PENTAPEPTIDE B,C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
expression_system_common: Chinese hamster
expression_system_cell_line: CHO
mol_id organism_scientific
2
synthetic: yes
Authors : Xue, Y., Inghardt, T., Sjolin, L., Deinum, J.
Keywords : SERINE PROTEASE INHIBITOR, PAI-1, CARBOHYDRATE, INHIBITOR COMPLEX, PROTEASE INHIBITOR-PEPTIDE COMPLEX, HYDROLASE INHIBITOR-PEPTIDE complex
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

Xue, Y.,Bjorquist, P.,Inghardt, T.  et al.
(1998)  Structure  6 : 627 - 636

PubMed: 9634700
DOI: 10.1016/S0969-2126(98)00064-1

Reaction

Chain : A
UniProt : P05121 (PAI1_HUMAN)
Reaction : -