Het-PDB Navi2 (PDB: 1A7A)

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Ligands
Code	Name		Style	Show	Link
ADC	(1'R,2'S)-9-(2-hydroxy-3'-keto-cyclopenten-1-yl)adenine				PoSSuM
NAD	Nicotinamide-adenine-dinucleotide				PoSSuM

Non-standard Residues
Code	Name	Show
MSE	Selenomethionine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1A7A

Code :

1A7A PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

STRUCTURE OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE: DETERMINATION OF A 30 SELENIUM ATOM SUBSTRUCTURE FROM DATA AT A SINGLE WAVELENGTH

Release Data :

1999-04-20

Compound :

mol_id	molecule	chains
1	S-ADENOSYLHOMOCYSTEINE HYDROLASE	A,B
	ec: 3.3.1.1 other_details: SELENOMETHIONINE DERIVATIZED PROTEIN

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	tissue: PLACENTA expression_system_strain: B834 expression_system_cellular_location: CYTOPLASM

Authors :

Turner, M.A., Yuan, C.-S., Borchardt, R.T., Hershfield, M.S., Smith, G.D., Howell, P.L.

Keywords :

HYDROLASE, NAD BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.8 Å )

Citation :

Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.

Turner, M.A.,Yuan, C.S.,Borchardt, R.T. et al.
(1998) Nat.Struct.Biol. 5 : 369 - 376

Chain :

A, B

UniProt :

P23526 (SAHH_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	3.13.2.1	PubMed:10933798
	left-to-right	PubMed:10933798
Cofactor:	Evidence:	Note:
NAD(+)	ECO:0000269 \| PubMed:12590576 ECO:0000269 \| PubMed:9586999	Binds 1 NAD(+) per subunit.

PDB ID: 1A7A