Het-PDB Navi2 (PDB: 1A71)

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Ligands
Code	Name	Link
ETF	Trifluoroethanol	PoSSuM
NAD	Nicotinamide-adenine-dinucleotide	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1A71

Code :

1A71 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

TERNARY COMPLEX OF AN ACTIVE SITE DOUBLE MUTANT OF HORSE LIVER ALCOHOL DEHYDROGENASE, PHE93=>TRP, VAL203=>ALA WITH NAD AND TRIFLUOROETHANOL

Release Data :

1998-06-17

Compound :

mol_id	molecule	chains
1	LIVER ALCOHOL DEHYDROGENASE	A,B
	ec: 1.1.1.1 mutation: F93W, V203A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Equus caballus (taxid:9796)	Horse	Escherichia coli (taxid:562)
	organ: LIVER cellular_location: CYTOPLASM gene: LADH F93W V203A expression_system_strain: XL1-BLUE expression_system_cellular_location: CYTOPLASM expression_system_vector_type: HELPER PHAGE expression_system_vector: VCSM13 expression_system_plasmid: PHAGEMID PBPP-LADH expression_system_gene: LADH F93W,V203A

Authors :

Colby, T.D., Bahnson, B.J., Chin, J.K., Klinman, J.P., Goldstein, B.M.

Keywords :

OXIDOREDUCTASE (NAD(A)-CHOH(D)), LIVER, ALCOHOL, DEHYDROGENASE, LADH, ACTIVE SITE MUTANT, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.

Colby, T.D.,Bahnson, B.J.,Chin, J.K. et al.
(1998) Biochemistry 37 : 9295 - 9304

A Link between Protein Structure and Enzyme Catalyzed Hydrogen Tunneling

Bahnson, B.J.,Colby, T.D.,Chin, J.K. et al.
(1997) Proc.Natl.Acad.Sci.USA 94 : 12797

PDB ID: 1A71