Het-PDB Navi2 (PDB: 1A5Y)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
CSP	S-phosphocysteine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1A5Y

Code :

1A5Y PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE

Release Data :

1998-06-17

Compound :

mol_id	molecule	chains
1	PROTEIN TYROSINE PHOSPHATASE 1B	A
	ec: 3.1.3.48 fragment: CATALYTIC DOMAIN, RESIDUES 1 - 321 other_details: PHOSPHATE LINK TO CYS 215

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	cell_line: BA834 cellular_location: ER MEMBRANE expression_system_cell_line: BA834 expression_system_plasmid: PET18

Authors :

Pannifer, A.D.P., Flint, A.J., Tonks, N.K., Barford, D.

Keywords :

HYDROLASE, DEPHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 2.5 Å )

Citation :

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.

Pannifer, A.D.,Flint, A.J.,Tonks, N.K. et al.
(1998) J.Biol.Chem. 273 : 10454 - 10462

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 1A5Y