Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
MN Manganese (II) ion
Y3 4-acetylamino-5-hydroxynaphthalene-2,7-disulfonic acid
Code : 1A5V   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION
Release Data : 1998-05-27
Compound :
mol_id molecule chains
1 INTEGRASE A
ec: 2.7.7.49
fragment: CATALYTIC CORE DOMAIN
other_details: P03354 FRAGMENT OF POLYPROTEIN POL-RSVP
Source :
mol_id organism_scientific expression_system
1 Rous sarcoma virus (strain Schmidt-Ruppin)  (taxid:11889) Escherichia coli  (taxid:562)
strain: Schmidt-Ruppin
expression_system_plasmid: PRC23IN(52-207)
other_details: SEE JRNL REFERENCE
Authors : Lubkowski, J., Yang, F., Alexandratos, J., Wlodawer, A.
Keywords : HYDROLASE, ENDONUCLEASE, HIV-1 INTEGRASE INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor.

Lubkowski, J.,Yang, F.,Alexandratos, J.  et al.
(1998)  Proc.Natl.Acad.Sci.USA  95 : 4831 - 4836

PubMed: 9560188
DOI: 10.1073/pnas.95.9.4831

Chain : A
UniProt : P03354 (POL_RSVP)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Endonucleolytic cleavage to 5'- phosphomonoester.