Brand  (β version)

PDB ID: 1A5S

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Ligands
Code Name Style Show Link
FIP 5-fluoroindole propanol phosphate PoSSuM
NA Sodium ion PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
SER Serine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1A5S   PDBj   RCSB PDB   PDBe
Header : COMPLEX (LYASE/INHIBITOR)
Title : CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE AND L-SER BOUND AS AMINO ACRYLATE TO THE BETA SITE
Release Data : 1999-03-30
Compound :
mol_id molecule chains
1 TRYPTOPHAN SYNTHASE (ALPHA CHAIN) A
ec: 4.2.1.20
mol_id molecule chains
2 TRYPTOPHAN SYNTHASE (BETA CHAIN) B
ec: 4.2.1.20
Source :
mol_id organism_scientific expression_system
1 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
cell_line: CB149
gene: TRPA/TRPB
expression_system_plasmid: PSTB7
mol_id organism_scientific expression_system
2 Salmonella typhimurium  (taxid:602) Escherichia coli  (taxid:562)
cell_line: CB149
gene: TRPA/TRPB
expression_system_plasmid: PSTB7
Authors : Schneider, T.R., Gerhardt, E., Lee, M., Liang, P.-H., Anderson, K.S., Schlichting, I.
Keywords : LYASE, CARBON-OXYGEN LYASE, TRYPTOPHAN BIOSYNTHESIS, PYRIDOXAL PHOSPHATE, COMPLEX (LYASE-INHIBITOR), COMPLEX (LYASE-INHIBITOR) complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Loop closure and intersubunit communication in tryptophan synthase.

Schneider, T.R.,Gerhardt, E.,Lee, M.  et al.
(1998)  Biochemistry  37 : 5394 - 5406

PubMed: 9548921
DOI: 10.1021/bi9728957

Reaction

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 HAMAP-Rule:MF_00131
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Chain : B
UniProt : P00933 (TRPB_SALTY)
Reaction: EC: Evidence:
Physiological Direction:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + H2O + L-tryptophan 4.2.1.20 -
-