Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0GJ L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide
Code : 1A5I
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : CATALYTIC DOMAIN OF VAMPIRE BAT (DESMODUS ROTUNDUS) SALIVA PLASMINOGEN ACTIVATOR IN COMPLEX WITH EGR-CMK (GLU-GLY-ARG CHLOROMETHYL KETONE)
Release Data : 1999-03-23
Compound :
mol_id molecule chains
1 PLASMINOGEN ACTIVATOR A
ec: 3.4.21.68
fragment: UNP residues 213-477
Source :
mol_id organism_scientific organism_common expression_system
1 Desmodus rotundus  (taxid:9430) Common vampire bat Mesocricetus auratus  (taxid:10036)
organ: SALIVARY GLANDS
expression_system_common: Golden hamster
expression_system_cell_line: BHK
Authors : Renatus, M., Stubbs, M.T., Bode, W.
Keywords : SERINE PROTEASE, FIBRINOLYTIC ENZYMES, PLASMINOGEN ACTIVATORS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage.

Renatus, M.,Stubbs, M.T.,Huber, R.  et al.
(1997)  Biochemistry  36 : 13483 - 13493

PubMed: 9354616
DOI: 10.1021/bi971129x

Lysine 156 Promotes the Anomalous Proenzyme Activity of Tpa: X-Ray Crystal Structure of Single-Chain Human Tpa

Renatus, M.,Engh, R.A.,Stubbs, M.T.  et al.
(1997)  Embo J.  16 : 4797

Tissue-Type Plasminogen Activator: Variants and Crystal/Solution Structures Demarcate Structural Determinants of Function

Bode, W.,Renatus, M.
(1997)  Curr.Opin.Struct.Biol.  7 : 865

The 2.3 A Crystal Structure of the Catalytic Domain of Recombinant Two-Chain Human Tissue-Type Plasminogen Activator

Lamba, D.,Bauer, M.,Huber, R.  et al.
(1996)  J.Mol.Biol.  258 : 117

Chain : A
UniProt : P98119 (URT1_DESRO)
Reaction : Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.