Het-PDB Navi2 (PDB: 1A5B)

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Ligands
Code	Name	Link
IGP	Indole-3-glycerol phosphate	PoSSuM
K	Potassium ion	PoSSuM
PLP	Pyridoxal-5'-phosphate	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1A5B

Code :

1A5B PDBj RCSB PDB PDBe

Header :

LYASE

Title :

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

Release Data :

1998-05-27

Compound :

mol_id	molecule	chains
1	TRYPTOPHAN SYNTHASE (ALPHA CHAIN)	A
	ec: 4.2.1.20 mutation: D60N other_details: LIGAND INDOLE-3-GLYCEROL PHOSPHATE BOUND TO THE A-SUBUNIT

mol_id	molecule	chains
2	TRYPTOPHAN SYNTHASE (BETA CHAIN)	B
	ec: 4.2.1.20 other_details: LIGAND INDOLE-3-GLYCEROL PHOSPHATE BOUND TO THE A-SUBUNIT

Source :

mol_id	organism_scientific	expression_system
1	Salmonella typhimurium (taxid:602)	Escherichia coli (taxid:562)
	cell_line: CB149 gene: TRPA/TRPB expression_system_cell_line: CB149 expression_system_plasmid: PSTB7 expression_system_gene: TRPA/TRPB

mol_id	organism_scientific	expression_system
2	Salmonella typhimurium (taxid:602)	Escherichia coli (taxid:562)
	cell_line: CB149 gene: TRPA/TRPB expression_system_cell_line: CB149 expression_system_plasmid: PSTB7 expression_system_gene: TRPA/TRPB

Authors :

Rhee, S., Miles, E.W., Davies, D.R.

Keywords :

CARBON-OXYGEN LYASE, MUTATION AT POSITION 60 (ASP --> ASN) IN THE A-SUBUNIT, TRUE SUBSTRATE INDOLE-3-GLYCEROL PHOSPHATE IN THE A-SUBUNIT, LYASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49.

Rhee, S.,Miles, E.W.,Davies, D.R.
(1998) J.Biol.Chem. 273 : 8553 - 8555

PubMed: 9535826
DOI: 10.1074/jbc.273.15.8553

Chain :

UniProt :

P00929 (TRPA_SALTY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O	4.2.1.20	HAMAP-Rule:MF_00131
	-	HAMAP-Rule:MF_00131

Chain :

UniProt :

P0A2K1 (TRPB_SALTY)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D- glyceraldehyde 3-phosphate + L-tryptophan + H2O	4.2.1.20	-
	-	-
Cofactor:	Evidence:	Note:
pyridoxal 5'-phosphate	-	-

PDB ID: 1A5B

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Structure summary

Reaction