Brand  (β version)

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Ligands
Code Name Link
FIP 5-fluoroindole propanol phosphate
NA Sodium ion
PLP Pyridoxal-5'-phosphate
Code : 1A50   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : CRYSTAL STRUCTURE OF WILD-TYPE TRYPTOPHAN SYNTHASE COMPLEXED WITH 5-FLUOROINDOLE PROPANOL PHOSPHATE
Release Data : 1999-03-30
Compound :
mol_id molecule chains
1 TRYPTOPHAN SYNTHASE (ALPHA CHAIN) A
ec: 4.2.1.20
other_details: INHIBITOR 5-FLUOROINDOLE PROPANOL PHOSPHATE BOUND TO THE ALPHA SITE
mol_id molecule chains
2 TRYPTOPHAN SYNTHASE (BETA CHAIN) B
ec: 4.2.1.20
other_details: INHIBITOR 5-FLUOROINDOLE PROPANOL PHOSPHATE BOUND TO THE ALPHA SITE
Source :
mol_id organism_scientific
1 Salmonella typhimurium  (taxid:602)
cell_line: CB149
plasmid: PSTB7
mol_id organism_scientific
2 Salmonella typhimurium  (taxid:602)
cell_line: CB149
plasmid: PSTB7
Authors : Schneider, T.R., Gerhardt, E., Lee, M., Liang, P.-H., Anderson, K.S., Schlichting, I.
Keywords : LYASE, CARBON-OXYGEN LYASE, TRYPTOPHAN BIOSYNTHESIS, PYRIDOXAL PHOSPHATE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Loop closure and intersubunit communication in tryptophan synthase.

Schneider, T.R.,Gerhardt, E.,Lee, M.  et al.
(1998)  Biochemistry  37 : 5394 - 5406

PubMed: 9548921
DOI: 10.1021/bi9728957

Chain : A
UniProt : P00929 (TRPA_SALTY)
Reaction : L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.
Chain : B
UniProt : P0A2K1 (TRPB_SALTY)
Reaction : L-serine + 1-C-(indol-3-yl)glycerol 3- phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H(2)O.