Brand  (β version)

PDB ID: 1A4R

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Ligands
Code Name Style Show Link
GDP Guanosine-5'-diphosphate PoSSuM
GNH Aminophosphonic acid-guanylate ester PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1A4R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM
Release Data : 1999-03-02
Compound :
mol_id molecule chains synonym
1 G25K GTP-BINDING PROTEIN A,B G25K, CDC42 HOMOLOG
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
cell_line: BL21
tissue: PLACENTA
cellular_location: CYTOPLASM, INNER SIDE OF MEMBRANE
expression_system_strain: BL21 (DE3)
expression_system_cellular_location: CYTOPLASM
expression_system_vector_type: PLASMID
expression_system_vector: ESCHERICHIA COLI
expression_system_plasmid: PGEX2T
Authors : Rudolph, M.G., Vetter, I.R., Wittinghofer, A.
Keywords : HYDROLASE, GTPASE, SIGNAL TRANSDUCTION
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.

Rudolph, M.G.,Wittinghofer, A.,Vetter, I.R.
(1999)  Protein Sci.  8 : 778 - 787

PubMed: 10211824

Reaction

Chain : A, B
UniProt : P60953 (CDC42_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:21565175, PubMed:23940119
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