Brand  (β version)

PDB ID: 1A4I

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Ligands
Code Name Style Show Link
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1A4I   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE
Release Data : 1999-02-09
Compound :
mol_id molecule chains synonym
1 METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE A,B METHYLENETHF DEHYDROGENASE / METHENYLTHF CYCLOHYDROLASE
ec: 1.5.1.5, 3.5.4.9
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cellular_location: CYTOPLASM
Authors : Allaire, M., Li, Y., Mackenzie, R.E., Cygler, M.
Keywords : THF, BIFUNCTIONAL, DEHYDROGENASE, CYCLOHYDROLASE, FOLATE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.5 Å )
Citation :

The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution.

Allaire, M.,Li, Y.,MacKenzie, R.E.  et al.
(1998)  Structure  6 : 173 - 182

PubMed: 9519408
DOI: 10.1016/S0969-2126(98)00019-7

Reaction

Chain : A, B
UniProt : P11586 (C1TC_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)- 5,10-methenyltetrahydrofolate + NADPH 1.5.1.5 PubMed:10828945, PubMed:18767138, PubMed:1881876
left-to-right PubMed:1881876
(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10- formyltetrahydrofolate + H(+) 3.5.4.9 PubMed:10828945, PubMed:1881876
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(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10- formyltetrahydrofolate + ADP + phosphate 6.3.4.3 PubMed:18767138, PubMed:1881876
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