Brand  (β version)

PDB ID: 1A48

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Ligands
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SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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ACE Acetyl group

Structure summary

Code : 1A48   PDBj   RCSB PDB   PDBe
Header : ATP BINDING PROTEIN
Title : SAICAR SYNTHASE
Release Data : 1999-03-30
Compound :
mol_id molecule chains synonym
1 PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE A SAICAR SYNTHETASE
ec: 6.3.2.6
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Baker's yeast
strain: GRF18
Authors : Levdikov, V.M., Melik-Adamyan, W.R., Lamzin, V.S., Wilson, K.S.
Keywords : ATP BINDING PROTEIN, PHOSPHORIBOSYLAMINOIMIDAZOLESUCCINOCARBOXAMIDE (SAICAR) SYNTHASE, PURINE BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis.

Levdikov, V.M.,Barynin, V.V.,Grebenko, A.I.  et al.
(1998)  Structure  6 : 363 - 376

PubMed: 9551557
DOI: 10.1016/S0969-2126(98)00038-0

[Substrate Specificity of Phosphoribosyl-Aminoimidazole-Succinocarboxyamide Synthetase (Saicar-Synthetase) from Saccharomyces Cerevisiae Yeast] (Russian)

Alenin, V.V.,Ostanin, K.V.,Kostikova, T.R.  et al.
(1992)  Biokhimiia  57 : 845

Crystallization and Preliminary X-Ray Investigation of Phosphoribosylaminoimidazolesuccinocarboxamide Synthase from the Yeast Saccharomyces Cerevisiae

Grebenko, A.I.,Levdikov, V.M.,Barynin, V.V.  et al.
(1992)  J.Mol.Biol.  228 : 298

De Novo Purine Nucleotide Biosynthesis

Zalkin, H.,Dixon, J.E.
(1992)  Prog.Nucleic Acid Res.Mol.Biol.  42 : 259

The Saccharomyces Cerevisiae Ade1 Gene: Structure, Overexpression and Possible Regulation by General Amino Acid Control

Myasnikov, A.N.,Sasnauskas, K.V.,Janulaitis, A.A.  et al.
(1991)  Gene  109 : 143

[Isolation and Properties of Phosphoribosyl-Aminoimidazole-Succinocarboxyamide-Synthetase from Saccharomyces Cerevisiae Yeasts] (Russian)

Ostanin, K.V.,Alenin, V.V.,Domkin, V.D.  et al.
(1989)  Biokhimiia  54 : 1265

[Nucleotide Sequence of the Ade 1 Gene of the Yeast Saccharomyces Cerevisiae] (Russian)

Miasnikov, A.N.,Plavnik, Iu.A.,Sasnauskas, K.V.  et al.
(1986)  Bioorg.Khim.  12 : 555

Reaction

Chain : A
UniProt : P27616 (PUR7_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole- 4-carboxamido]succinate + ADP + 2 H(+) + phosphate 6.3.2.6 PubMed:1756975
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