Brand  (β version)

color scheme of protein:

hetatm:
centroid:

chain:

Ligands
Code Name Link
HG Mercury (II) ion
ZN Zinc ion
BZU (4r)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2h-thieno[3,2-E][1,2]thiazine-6-sulfonamide 1,1-dioxide
Code : 1A42
Header : LYASE
Title : HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
Release Data : 1999-03-23
Compound :
mol_id molecule chains
1 CARBONIC ANHYDRASE II A
ec: 4.2.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HUMAN CAII
expression_system_gene: HUMAN CAII
Authors : Boriack-Sjodin, P.A., Christianson, D.W.
Keywords : LYASE, ZINC, INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.

Stams, T.,Chen, Y.,Boriack-Sjodin, P.A.  et al.
(1998)  Protein Sci.  7 : 556 - 563

PubMed: 9541386

Structural Analysis of Inhibitor Binding to Human Carbonic Anhydrase II

Boriack-Sjodin, P.A.,Zeitlin, S.,Chen, H.H.  et al.
(1998)  Protein Sci.  7 : 2483

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction : H(2)CO(3) = CO(2) + H(2)O.