Brand  (β version)

PDB ID: 1A3R

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Ligands
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Glycosylation
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NH2 Amino group

Structure summary

Code : 1A3R   PDBj   RCSB PDB   PDBe
Header : Viral protein/Immune system
Title : FAB FRAGMENT (ANTIBODY 8F5) COMPLEXED WITH PEPTIDE FROM HUMAN RHINOVIRUS (SEROTYPE 2) VIRAL CAPSID PROTEIN VP2 (RESIDUES 156-170)
Release Data : 1998-04-29
Compound :
mol_id molecule chains synonym
1 IGG2A 8F5 FAB (LIGHT CHAIN) L ANTIBODY 8F5
fragment: FAB FRAGMENT (PAPAIN DIGESTION)
mol_id molecule chains synonym
2 IGG2A 8F5 FAB (HEAVY CHAIN) H ANTIBODY 8F5
fragment: FAB FRAGMENT (PAPAIN DIGESTION)
mol_id molecule chains
3 HUMAN RHINOVIRUS CAPSID PROTEIN VP2 P
fragment: RESIDUES 156 - 170
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) House mouse
mol_id organism_scientific organism_common
2 Mus musculus  (taxid:10090) House mouse
mol_id organism_scientific
3 Human rhinovirus 2  (taxid:12130)
strain: SEROTYPE 2
other_details: COMMON COLD VIRUS
Authors : Tormo, J., Blaas, D., Fita, I.
Keywords : IMMUNOGLOBULIN, ANTIBODY, RHINOVIRUS, NEUTRALIZATION, CONTINUOUS EPITOPE, COMPLEX (IMMUNOGLOBULIN-VIRAL PEPTIDE), Viral protein-Immune system COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2.

Tormo, J.,Blaas, D.,Parry, N.R.  et al.
(1994)  EMBO J.  13 : 2247 - 2256

PubMed: 8194515

Three-Dimensional Structure of the Fab Fragment of a Neutralizing Antibody to Human Rhinovirus Serotype 2

Tormo, J.,Stadler, E.,Skern, T.  et al.
(1992)  Protein Sci.  1 : 1154

Crystallization and Preliminary X-Ray Diffraction Studies of the Fab Fragment of a Neutralizing Monoclonal Antibody Directed Against Human Rhinovirus Serotype 2

Tormo, J.,Fita, I.,Kanzler, O.  et al.
(1990)  J.Biol.Chem.  265 : 16799

Reaction

Chain : P
UniProt : P04936 (POLG_HRV2)
Reaction: EC: Evidence:
Physiological Direction:
[Protein 2C]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + phosphate + H(+) 		3.6.1.15 UniProtKB:P03300
-
[Protease 2A]
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. 		3.4.22.29 UniProtKB:P03300
-
[RNA-directed RNA polymerase]
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate 		2.7.7.48 PROSITE-ProRule:PRU00539
-
[Protease 3C]
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. 		3.4.22.28 PROSITE-ProRule:PRU01222
-
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P03300
Binds 2 magnesium ions that constitute a dinuclear catalytic metal center (By similarity). The magnesium ions are not prebound but only present for catalysis (By similarity). Requires the presence of 3CDpro or 3CPro (By similarity).