Het-PDB Navi2 (PDB: 1A35)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
BRU	5-bromo-2'-deoxyuridine-5'-monophosphate

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1A35

Code :

1A35 PDBj RCSB PDB PDBe

Header :

ISOMERASE/DNA

Title :

HUMAN TOPOISOMERASE I/DNA COMPLEX

Release Data :

1998-08-28

Compound :

mol_id	molecule	chains
1	DNA (5'-D(APAPAPAPAPGPAPCPTPTPAPGPAPAPAPAPAP(BRU)P(BRU)PTPTPT)-3')	C

mol_id	molecule	chains
2	DNA (5'-D(APAPAPAPAPTP+UP+UP+UP+UPCP+UPAPAPGPTPCPTPTPTP+ UPT)-3')	D

mol_id	molecule	chains
3	PROTEIN (DNA TOPOISOMERASE I)	A
	ec: 5.99.1.2 fragment: CORE DOMAIN AND C-TERMINAL DOMAIN mutation: Y723F

Source :

mol_id	organism_scientific
1
	synthetic: yes

mol_id	organism_scientific
2
	synthetic: yes

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	cellular_location: NUCLEUS expression_system_common: Fall armyworm expression_system_vector: BACULOVIRUS

Authors :

Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.

Keywords :

TOPOISOMERASE I/DNA), DNA, TOPOISOMERASE I, ISOMERASE-DNA COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.500 Å )

Citation :

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.

Redinbo, M.R.,Stewart, L.,Kuhn, P. et al.
(1998) Science 279 : 1504 - 1513

PDB ID: 1A35