Brand  (β version)

PDB ID: 1A2C

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Ligands
Code Name Style Show Link
NA Sodium ion PoSSuM
Non-standard Residues
Code Name Show
OAR N-(4-amino-5-hydroxy-pentyl)-guanidine
PRJ (2s,3as,6r,7as)-6-hydroxyoctahydro-1h-indole-2-carboxylic acid
TYS O-sulfo-L-tyrosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
34H (2r)-2-hydroxy-3-(4-hydroxyphenyl)propanoic acid

Structure summary

Code : 1A2C   PDBj   RCSB PDB   PDBe
Header : Hydrolase/Hydrolase Inhibitor
Title : Structure of thrombin inhibited by AERUGINOSIN298-A from a BLUE-GREEN ALGA
Release Data : 1998-07-01
Compound :
mol_id molecule chains
1 Thrombin light chain L
ec: 3.4.21.5
mol_id molecule chains
2 Thrombin heavy chain H
ec: 3.4.21.5
mol_id molecule chains
3 Hirudin variant-2 I
fragment: UNP residues 60-71
mol_id molecule chains
4 Aeruginosin 298-A J
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
3 Hirudo medicinalis  (taxid:6421)
mol_id organism_scientific
4 Microcystis aeruginosa  (taxid:1126)
Authors : Rios-Steiner, J.L., Murakami, M., Tulinsky, A.
Keywords : HYDROLASE, SERINE PROTEASE, Hydrolase-Hydrolase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Structure of Thrombin Inhibited by Aeruginosin 298-A from a Blue-Green Alga

Steiner, J.L.R.,Murakami, M.,Tulinsky, A.
(1998)  J.Am.Chem.Soc.  120 : 597

PubMed: -1

Aeruginosin 298-A, a Thrombin and Trypsin Inhibitor from the Blue-Green Alga Microcystis Aeruginosa (Nies-298)

Murakami, M.,Okita, Y.,Matsuda, H.  et al.
(1994)  Tetrahedron Lett.  35 : 3129

Refined Structure of the Hirudin-Thrombin Complex

Rydel, T.J.,Tulinsky, A.,Bode, W.  et al.
(1991)  J.Mol.Biol.  221 : 583

The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin

Rydel, T.J.,Ravichandran, K.G.,Tulinsky, A.  et al.
(1990)  Science  249 : 277

Reaction

Chain : H
UniProt : P00734 (THRB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B. 3.4.21.5 -
-
Chain : I
UniProt : P09945 (HIRV2_HIRME)
Reaction : -