Het-PDB Navi2 (PDB: 1A27)

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Ligands
Code	Name		Style	Show	Link
EST	Estradiol				PoSSuM
NAP	Nadp nicotinamide-adenine-dinucleotide phosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1A27

Code :

1A27 PDBj RCSB PDB PDBe

Header :

DEHYDROGENASE

Title :

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 C-TERMINAL DELETION MUTANT COMPLEXED WITH ESTRADIOL AND NADP+

Release Data :

1998-05-27

Compound :

mol_id	molecule	chains
1	17-BETA-HYDROXYSTEROID-DEHYDROGENASE	A
	ec: 1.1.1.62 mutation: C-TERMINAL DELETION (290 - 327)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Unidentified baculovirus (taxid:10469)
	cell_line: SPODOPTERA FRUGIPERDA cellular_location: CYTOPLASM expression_system_cell_line: SPODOPTERA FRUGIPERDA expression_system_cellular_location: CYTOPLASM expression_system_vector_type: VIRUS expression_system_vector: BACULOVIRUS expression_system_plasmid: PVL1393

Authors :

Mazza, C., Breton, R., Housset, D., Fontecilla-Camps, J.-C.

Keywords :

DEHYDROGENASE, 17-BETA-HYDROXYSTEROID, MUTANT, ESTRADIOL, NADP

Exp. method :

X-RAY DIFFRACTION ( 1.9 Å )

Citation :

Human Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis

Mazza, C.
(1997) Thesis, Universite Joseph Fourier

PubMed: -1

Unusual Charge Stabilization of Nadp+ in 17Beta-Hydroxysteroid Dehydrogenase

Mazza, C.,Breton, R.,Housset, D. et al.
(1998) J.Biol.Chem. 273 : 8145

The Structure of a Complex of Human 17Beta-Hydroxysteroid Dehydrogenase with Estradiol and Nadp+ Identifies Two Principal Targets for the Design of Inhibitors

Breton, R.,Housset, D.,Mazza, C. et al.
(1996) Structure 4 : 905

Structure of Human Estrogenic 17 Beta-Hydroxysteroid Dehydrogenase at 2.20 A Resolution

Ghosh, D.,Pletnev, V.Z.,Zhu, D.W. et al.
(1995) Structure 3 : 503

Chain :

UniProt :

P14061 (DHB1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
17beta-estradiol + NAD(+) = estrone + H(+) + NADH	1.1.1.62	PubMed:8994190
17beta-estradiol + NAD(+) = estrone + H(+) + NADH	-	PubMed:8994190
17beta-estradiol + NADP(+) = estrone + H(+) + NADPH	1.1.1.62	UniProtKB:P51656
17beta-estradiol + NADP(+) = estrone + H(+) + NADPH	right-to-left	UniProtKB:P51656
NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH	1.1.1.51	UniProtKB:P51656
	right-to-left	UniProtKB:P51656

PDB ID: 1A27

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