Brand  (β version)

PDB ID: 1A26

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Ligands
Code Name Style Show Link
CNA Carba-nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 1A26   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH CARBA-NAD
Release Data : 1998-05-27
Compound :
mol_id molecule chains synonym
1 POLY (ADP-RIBOSE) POLYMERASE A PARP-CF, POLY(ADP-RIBOSE) TRANSFERASE, POLY (ADP-RIBOSE) SYNTHETASE
ec: 2.4.2.30
fragment: CATALYTIC FRAGMENT
Source :
mol_id organism_scientific organism_common expression_system
1 Gallus gallus  (taxid:9031) Chicken Spodoptera frugiperda  (taxid:7108)
cell_line: SF9
organelle: NUCLEUS
expression_system_common: Fall armyworm
expression_system_strain: SF9
expression_system_cell_line: SF9
expression_system_vector_type: VIRUS
expression_system_vector: BACULOVIRUS
expression_system_plasmid: PVLPE
Authors : Ruf, A., Schulz, G.E.
Keywords : TRANSFERASE, GLYCOSYLTRANSFERASE, NAD(+) ADP-RIBOSYLTRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.25 Å )
Citation :

The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis.

Ruf, A.,Rolli, V.,de Murcia, G.  et al.
(1998)  J.Mol.Biol.  278 : 57 - 65

PubMed: 9571033
DOI: 10.1006/jmbi.1998.1673

Structure of the Catalytic Fragment of Poly(Ad-Ribose) Polymerase from Chicken

Ruf, A.,Mennissier De Murcia, J.,De Murcia, G.M.  et al.
(1996)  Proc.Natl.Acad.Sci.USA  93 : 7481

Crystallization and X-Ray Crystallographic Analysis of Recombinant Chicken Poly(Adp-Ribose) Polymerase Catalytic Domain Produced in Sf9 Insect Cells

Jung, S.,Miranda, E.A.,De Murcia, J.M.  et al.
(1994)  J.Mol.Biol.  244 : 114

Reaction

Chain : A
UniProt : P26446 (PARP1_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 UniProtKB:P09874
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L-seryl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-seryl- [protein] + nicotinamide + H(+) - UniProtKB:P09874
left-to-right
L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - UniProtKB:P11103
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L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - UniProtKB:P11103
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L-tyrosyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-tyrosyl- [protein] + nicotinamide + H(+) - UniProtKB:P09874
left-to-right
L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L- histidyl-[protein] + nicotinamide + H(+) - UniProtKB:P09874
left-to-right