Het-PDB Navi2 (PDB: 1A1C)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
DIX	Methyl(cyclopentyl-propyl)amine

Download interaction data: 1A1C

Code :

1A1C PDBj RCSB PDB PDBe

Header :

COMPLEX (TRANSFERASE/PEPTIDE)

Title :

C-SRC (SH2 DOMAIN) COMPLEXED WITH ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))

Release Data :

1998-04-08

Compound :

mol_id	molecule	chains
1	C-SRC TYROSINE KINASE	A,B
	ec: 2.7.1.112 fragment: SH2 DOMAIN

mol_id	molecule	chains
2	ACE-PHOSPHOTYR-GLU-(N-ME(-(CH2)3-CYCLOPENTYL))	C,D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:511693)
	cellular_location: CYTOPLASM gene: SRC expression_system_strain: BL21 expression_system_cellular_location: CYTOPLASM expression_system_plasmid: PET11B expression_system_gene: SRC

mol_id	organism_scientific
2

Authors :

Shewchuk, L., Jordan, S.

Keywords :

COMPLEX (TRANSFERASE-PEPTIDE), COMPLEX (TRANSFERASE-PEPTIDE) complex

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.

Charifson, P.S.,Shewchuk, L.M.,Rocque, W. et al.
(1997) Biochemistry 36 : 6283 - 6293

Chain :

A, B

UniProt :

P12931 (SRC_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	PROSITE-ProRule:PRU10028, PubMed:14632929, PubMed:19307596, PubMed:21036157, PubMed:35927303, PubMed:7929427, PubMed:8759729, PubMed:9571170
	-
[Isoform 1] ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	UniProtKB:Q9WUD9
	-	UniProtKB:Q9WUD9
[Isoform 2] ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	UniProtKB:Q9WUD9
	-	UniProtKB:Q9WUD9
[Isoform 3] ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.2	UniProtKB:Q9WUD9
	-	UniProtKB:Q9WUD9

PDB ID: 1A1C