Het-PDB Navi2 (PDB: 1A0H)

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Ligands
Code	Name		Style	Show	Link
0G6	D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 1A0H

Code :

1A0H PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

THE X-RAY CRYSTAL STRUCTURE OF PPACK-MEIZOTHROMBIN DESF1: KRINGLE/THROMBIN AND CARBOHYDRATE/KRINGLE/THROMBIN INTERACTIONS AND LOCATION OF THE LINKER CHAIN

Release Data :

1998-06-17

Compound :

mol_id	molecule	chains	synonym
1	MEIZOTHROMBIN	A,D	DESF1
	ec: 3.4.21.5 fragment: F2/THROMBIN DOMAIN

mol_id	molecule	chains	synonym
2	MEIZOTHROMBIN	B,E	DESF1
	ec: 3.4.21.5 fragment: F2/THROMBIN DOMAIN

Source :

mol_id	organism_scientific	organism_common
1	Bos taurus (taxid:9913)	Cattle
	organ: BLOOD tissue: BLOOD PLASMA

mol_id	organism_scientific	organism_common
2	Bos taurus (taxid:9913)	Cattle
	organ: BLOOD tissue: BLOOD PLASMA

Authors :

Martin, P.D., Malkowski, M.G., Box, J., Esmon, C.T., Edwards, B.F.P.

Keywords :

SERINE PROTEASE, COAGULATION, THROMBIN, PROTHROMBIN, MEIZOTHROMBIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 3.2 Å )

Citation :

New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.

Martin, P.D.,Malkowski, M.G.,Box, J. et al.
(1997) Structure 5 : 1681 - 1693

PubMed: 9438869
DOI: 10.1016/S0969-2126(97)00314-6

Chain :

B, E

UniProt :

P00735 (THRB_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1A0H

Hetero Atom Contents

Structure summary

Reaction