Brand  (β version)

PDB ID: 16PK

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Ligands
Code Name Style Show Link
BIS 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester PoSSuM
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 16PK   PDBj   RCSB PDB   PDBe
Header : KINASE
Title : PHOSPHOGLYCERATE KINASE FROM TRYPANOSOMA BRUCEI BISUBSTRATE ANALOG
Release Data : 1998-11-25
Compound :
mol_id molecule chains synonym
1 3-PHOSPHOGLYCERATE KINASE A PGK
ec: 2.7.2.3
mutation: TRUNCATION OF T. BRUCEI SPECIFIC C-TERMINAL SEQUENCE
Source :
mol_id organism_scientific expression_system
1 Trypanosoma brucei  (taxid:5691) Escherichia coli BL21  (taxid:511693)
variant: GLYCOSOMAL VERSION
organelle: GLYCOSOME
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: PET21A
Authors : Bernstein, B.E., Bressi, J., Blackburn, M., Gelb, M., Hol, W.G.J.
Keywords : KINASE, PHOSPHOGLYCERATE, TERNARY COMPLEX, GLYCOLYSIS, TRANSFERASE, BISUBSTRATE, ANALOG
Exp. method : X-RAY DIFFRACTION ( 1.6 Å )
Citation :

A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei.

Bernstein, B.E.,Williams, D.M.,Bressi, J.C.  et al.
(1998)  J.Mol.Biol.  279 : 1137 - 1148

PubMed: 9642090
DOI: 10.1006/jmbi.1998.1835

Reaction

Chain : A
UniProt : P07378 (PGKC_TRYBB)
Reaction: EC: Evidence:
Physiological Direction:
(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP 2.7.2.3 UniProtKB:P00558
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:9000079
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