Het-PDB Navi2 (PDB: 12CA)

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Ligands
Code	Name		Style	Show	Link
HG	Mercury (II) ion				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 12CA

Code :

12CA PDBj RCSB PDB PDBe

Header :

LYASE(OXO-ACID)

Title :

ALTERING THE MOUTH OF A HYDROPHOBIC POCKET. STRUCTURE AND KINETICS OF HUMAN CARBONIC ANHYDRASE II MUTANTS AT RESIDUE VAL-121

Release Data :

1992-10-15

Compound :

mol_id	molecule	chains
1	CARBONIC ANHYDRASE II	A
	ec: 4.2.1.1

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

Authors :

Nair, S.K., Christianson, D.W.

Keywords :

LYASE(OXO-ACID)

Exp. method :

X-RAY DIFFRACTION ( 2.4 Å )

Citation :

Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.

Nair, S.K.,Calderone, T.L.,Christianson, D.W. et al.
(1991) J.Biol.Chem. 266 : 17320 - 17325

PubMed: 1910042

Chain :

UniProt :

P00918 (CAH2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
hydrogencarbonate + H(+) = CO2 + H2O	4.2.1.1	PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308
hydrogencarbonate + H(+) = CO2 + H2O	-
urea = cyanamide + H2O	4.2.1.69	PubMed:10550681, PubMed:11015219
urea = cyanamide + H2O	-	PubMed:10550681, PubMed:11015219
Cofactor:	Evidence:	Note:
Co(2+)	ECO:0000269 \| PubMed:11076507 ECO:0000269 \| PubMed:12499545 ECO:0000269 \| PubMed:1336460 ECO:0000269 \| PubMed:1433293 ECO:0000269 \| PubMed:1909891 ECO:0000269 \| PubMed:19583303 ECO:0000269 \| PubMed:3151019 ECO:0000269 \| PubMed:3151020 ECO:0000269 \| PubMed:7761440 ECO:0000269 \| PubMed:7803386 ECO:0000269 \| PubMed:7901850 ECO:0000269 \| PubMed:8218160 ECO:0000269 \| PubMed:8262987 ECO:0000269 \| PubMed:8331673 ECO:0000269 \| PubMed:8399159 ECO:0000269 \| PubMed:8431430 ECO:0000269 \| PubMed:8451242 ECO:0000269 \| PubMed:8482389 ECO:0000269 \| PubMed:8639494 ECO:0000269 \| PubMed:8987974 ECO:0000269 \| PubMed:9398308 ECO:0000269 \| PubMed:9865942 ECO:0000269 \| PubMed:19583303	Zinc. Can also use cobalt(II) with lower efficiency, but not copper(II), nickel(II) and manganese(II).

PDB ID: 12CA

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