Brand  (β version)

PDB ID: 11GS

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Ligands
Code Name Style Show Link
EAA Ethacrynic acid PoSSuM
GSH Glutathione PoSSuM
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 11GS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Glutathione S-transferase complexed with ethacrynic acid-glutathione conjugate (form II)
Release Data : 1999-01-13
Compound :
mol_id molecule chains synonym
1 GLUTATHIONE S-TRANSFERASE A,B GST
ec: 2.5.1.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GSTP1
Authors : Oakley, A.J., Lo Bello, M., Mazzetti, A.P., Federici, G., Parker, M.W.
Keywords : TRANSFERASE, ETHACRYNIC ACID
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.

Oakley, A.J.,Lo Bello, M.,Mazzetti, A.P.  et al.
(1997)  FEBS Lett.  419 : 32 - 36

PubMed: 9426214
DOI: 10.1016/S0014-5793(97)01424-5

Reaction

Chain : A, B
UniProt : P09211 (GSTP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:1540159, PubMed:1567427, PubMed:8433974
left-to-right ECO:0000305
glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - PubMed:9084911
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glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione - PubMed:9084911
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glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione - PubMed:9084911
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11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate - PubMed:21046276
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