Brand  (β version)

PDB ID: 10MH

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Ligands
Code Name Style Show Link
SAH S-adenosyl-L-homocysteine PoSSuM
Non-standard Residues
Code Name Show
5CM 5-methyl-2'-deoxy-cytidine-5'-monophosphate
5NC 5-aza-cytidine-5'monophosphate
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 10MH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : TERNARY STRUCTURE OF HHAI METHYLTRANSFERASE WITH ADOHCY AND HEMIMETHYLATED DNA CONTAINING 5,6-DIHYDRO-5-AZACYTOSINE AT THE TARGET
Release Data : 1999-02-09
Compound :
mol_id molecule chains
1 DNA (5'-D(P*CP*CP*AP*TP*GP*(5CM)P*GP*CP*TP*GP*AP*C)-3') B
mol_id molecule chains
2 DNA (5'-D(P*GP*TP*CP*AP*GP*5NCP*GP*CP*AP*TP*GP*G)-3') C
mol_id molecule chains synonym
3 PROTEIN (CYTOSINE-SPECIFIC METHYLTRANSFERASE HHAI) A MODIFICATION METHYLASE HHAI, M.HHAI
ec: 2.1.1.73
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific expression_system
3 Haemophilus haemolyticus  (taxid:726) Escherichia coli  (taxid:562)
Authors : Sheikhnejad, G., Brank, A., Christman, J.K., Goddard, A., Alvarez, E., Ford Junior, H., Marquez, V.E., Marasco, C.J., Sufrin, J.R., O'Gara, M., Cheng, X.
Keywords : TRANSFERASE, METHYLTRANSFERASE, RESTRICTION SYSTEM, COMPLEX (METHYLTRANSFERASE- DNA), TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.55 Å )
Citation :

Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine.

Sheikhnejad, G.,Brank, A.,Christman, J.K.  et al.
(1999)  J.Mol.Biol.  285 : 2021 - 2034

PubMed: 9925782
DOI: 10.1006/jmbi.1998.2426

Reaction

Chain : A
UniProt : P05102 (MTH1_HAEPH)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine 2.1.1.37 PROSITE-ProRule:PRU10018, PubMed:7899082
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