Brand  (β version)

PDB ID: 10GS

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Ligands
Code Name Style Show Link
MES 2-(N-morpholino)-ethanesulfonic acid PoSSuM
VWW L-gamma-glutamyl-S-benzyl-N-[(S)-carboxy(phenyl)methyl]-L-cysteinamide PoSSuM
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Structure summary

Code : 10GS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
Release Data : 1998-09-16
Compound :
mol_id molecule chains synonym
1 GLUTATHIONE S-TRANSFERASE P1-1 A,B GSTP1-1
ec: 2.5.1.18
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
organ: PLACENTA
cellular_location: CYTOPLASM
gene: GTP_HUMAN
Authors : Oakley, A., Parker, M.
Keywords : DETOXIFYING ENZYME, TER117, TLK117, RP298, TELINTRA, EZATIOSTAT HCL, MYELODYSPLASTIC SYNDROME, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.

Oakley, A.J.,Bello, M.L.,Battistoni, A.  et al.
(1997)  J.Mol.Biol.  274 : 84 - 100

PubMed: 9398518
DOI: 10.1006/jmbi.1997.1364

Three-Dimensional Structure of Class Pi Glutathione S-Transferase from Human Placenta in Complex with S-Hexylglutathione at 2.8 A Resolution

Reinemer, P.,Dirr, H.W.,Ladenstein, R.  et al.
(1992)  J.Mol.Biol.  227 : 214

Reaction

Chain : A, B
UniProt : P09211 (GSTP1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
glutathione + RX = a halide anion + an S-substituted glutathione + H(+) 2.5.1.18 PubMed:1540159, PubMed:1567427, PubMed:8433974
left-to-right ECO:0000305
glutathione + prostaglandin J2 = prostaglandin J2-S-(R)- glutathione - PubMed:9084911
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glutathione + prostaglandin J2 = prostaglandin J2-S-(S)- glutathione - PubMed:9084911
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glutathione + prostaglandin A2 = prostaglandin A2-S-(S)- glutathione - PubMed:9084911
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11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)- eicosatrienoate - PubMed:21046276
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