ID	6GLAA	STANDARD;	PRT;	294	AA.
DT	CONVERTED FROM PDB (SEQRES) 6GLA
DE	Tyrosine-protein kinase JAK3
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.920
CC	R-Factor	0.228
FT	#SUB	109	 918 	ARG	A	82	 891 	TYR	B	Protein	S	1
FT	#SUB	109	 918 	ARG	A	83	 892 	GLY	B	Protein	S	5
FT	#SUB	109	 918 	ARG	A	84	 893 	PRO	B	Protein	S	5
FT	#SUB	110	 919 	ALA	A	9	 818 	GLU	B	Protein	B	1
FT	#SUB	110	 919 	ALA	A	11	 820 	ARG	B	Protein	A	4
FT	#SUB	214	1023 	TYR	A	82	 891 	TYR	B	Protein	S	1
FT	#SUB	216	1025 	ASP	A	84	 893 	PRO	B	Protein	S	3
FT	#SUB	216	1025 	ASP	A	85	 894 	GLY	B	Protein	S	3
FT	#SUB	218	1027 	SER	A	85	 894 	GLY	B	Protein	S	3
FT	#SUB	218	1027 	SER	A	86	 895 	ARG	B	Protein	S	1
FT	#SUB	227	1036 	ARG	A	86	 895 	ARG	B	Protein	S	1
FT	#SUB	256	1065 	ALA	A	82	 891 	TYR	B	Protein	S	2
FT	#HET	14	 823 	LYS	A	6	1206 	EDO	A	S	2
FT	#HET	18	 827 	GLN	A	3	1203 	EDO	A	A	6
FT	#HET	19	 828 	LEU	A	1	1201 	F4B	A	A	7
FT	#HET	20	 829 	GLY	A	1	1201 	F4B	A	B	3
FT	#HET	20	 829 	GLY	A	3	1203 	EDO	A	B	3
FT	#HET	21	 830 	LYS	A	3	1203 	EDO	A	A	2
FT	#HET	21	 830 	LYS	A	4	1204 	EDO	A	B	1
FT	#HET	22	 831 	GLY	A	4	1204 	EDO	A	B	1
FT	#HET	25	 834 	GLY	A	4	1204 	EDO	A	B	2
FT	#HET	26	 835 	SER	A	4	1204 	EDO	A	B	1
FT	#HET	27	 836 	VAL	A	1	1201 	F4B	A	S	1
FT	#HET	27	 836 	VAL	A	4	1204 	EDO	A	S	2
FT	#HET	31	 840 	ARG	A	6	1206 	EDO	A	S	7
FT	#HET	38	 847 	ASN	A	6	1206 	EDO	A	S	3
FT	#HET	44	 853 	ALA	A	1	1201 	F4B	A	S	3
FT	#HET	46	 855 	LYS	A	4	1204 	EDO	A	S	5
FT	#HET	75	 884 	VAL	A	1	1201 	F4B	A	S	1
FT	#HET	94	 903 	GLU	A	1	1201 	F4B	A	B	5
FT	#HET	95	 904 	TYR	A	1	1201 	F4B	A	A	5
FT	#HET	96	 905 	LEU	A	1	1201 	F4B	A	B	6
FT	#HET	100	 909 	CYS	A	1	1201 	F4B	A	S	9
FT	#HET	102	 911 	ARG	A	1	1201 	F4B	A	S	4
FT	#HET	102	 911 	ARG	A	7	1207 	EDO	A	S	8
FT	#HET	103	 912 	ASP	A	1	1201 	F4B	A	S	8
FT	#HET	139	 948 	ARG	A	5	1205 	EDO	A	B	1
FT	#HET	144	 953 	ARG	A	1	1201 	F4B	A	A	6
FT	#HET	145	 954 	ASN	A	1	1201 	F4B	A	S	1
FT	#HET	147	 956 	LEU	A	1	1201 	F4B	A	S	12
FT	#HET	158	 967 	ASP	A	4	1204 	EDO	A	S	3
FT	#HET	180	 989 	SER	A	8	1208 	EDO	A	B	2
FT	#HET	181	 990 	PRO	A	8	1208 	EDO	A	B	2
FT	#HET	182	 991 	ILE	A	8	1208 	EDO	A	A	3
FT	#HET	183	 992 	PHE	A	2	1202 	PHU	A	S	1
FT	#HET	184	 993 	TRP	A	5	1205 	EDO	A	B	1
FT	#HET	184	 993 	TRP	A	7	1207 	EDO	A	S	1
FT	#HET	185	 994 	TYR	A	5	1205 	EDO	A	A	10
FT	#HET	186	 995 	ALA	A	5	1205 	EDO	A	A	4
FT	#HET	189	 998 	SER	A	5	1205 	EDO	A	S	2
FT	#HET	195	1004 	PHE	A	5	1205 	EDO	A	S	3
FT	#HET	199	1008 	SER	A	5	1205 	EDO	A	A	12
FT	#HET	200	1009 	ASP	A	5	1205 	EDO	A	A	5
FT	#HET	202	1011 	TRP	A	2	1202 	PHU	A	S	3
FT	#HET	203	1012 	SER	A	5	1205 	EDO	A	S	3
FT	#HET	210	1019 	GLU	A	7	1207 	EDO	A	S	4
FT	#HET	215	1024 	CYS	A	7	1207 	EDO	A	A	7
FT	#HET	220	1029 	SER	A	7	1207 	EDO	A	S	1
FT	#HET	221	1030 	PRO	A	2	1202 	PHU	A	B	1
FT	#HET	228	1037 	MET	A	2	1202 	PHU	A	S	2
FT	#HET	241	1050 	LEU	A	2	1202 	PHU	A	S	2
FT	#HET	245	1054 	LEU	A	2	1202 	PHU	A	S	3
FT	#HET	250	1059 	ARG	A	2	1202 	PHU	A	A	4
FT	#HET	251	1060 	LEU	A	2	1202 	PHU	A	A	18
FT	#HET	269	1078 	TRP	A	2	1202 	PHU	A	S	7
FT	DISORDER	1	3
FT	DISORDER	176	178
CC	SEQUENCE	288 AA (ATOM);
CC	DPTIFEERHL KYISQLGKGN FGSVELCRYD PLGDNTGALV AVKQLQHSGP DQQRDFQREI
CC	QILKALHSDF IVKYRGVSYG PGRQSLRLVM EYLPSGCLRD FLQRHRARLD ASRLLLYSSQ
CC	ICKGMEYLGS RRCVHRALAA RNILVESEAH VKIADFGLAK LLPLDKDYYV VRQSPIFWYA
CC	PESLSDNIFS RQSDVWSFGV VLYELFTYCD KSCSPSAEFL RMMGSERDVP ALSRLLELLE
CC	EGQRLPAPPA CPAEVHELMK LCWAPSPQDR PSFSALGPQL DMLWSGSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	ATOM   ---DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	          ***********************************************
CC	SEQRES SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	ATOM   SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	       **************************************************
CC	SEQRES LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	ATOM   LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	       **************************************************
CC	SEQRES EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	ATOM   EAHVKIADFGLAKLLPLDKDYYVVR---QSPIFWYAPESLSDNIFSRQSD
CC	       *************************   **********************
CC	SEQRES VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	ATOM   VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	       **************************************************
CC	SEQRES LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	ATOM   LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	       ********************************************
SQ	SEQUENCE	294 AA;      MW;         CN;
	SMQDPTIFEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG ALVAVKQLQH SGPDQQRDFQ
	REIQILKALH SDFIVKYRGV SYGPGRQSLR LVMEYLPSGC LRDFLQRHRA RLDASRLLLY
	SSQICKGMEY LGSRRCVHRA LAARNILVES EAHVKIADFG LAKLLPLDKD YYVVREPGQS
	PIFWYAPESL SDNIFSRQSD VWSFGVVLYE LFTYCDKSCS PSAEFLRMMG SERDVPALSR
	LLELLEEGQR LPAPPACPAE VHELMKLCWA PSPQDRPSFS ALGPQLDMLW SGSR
//
ID	6GLAB	STANDARD;	PRT;	294	AA.
DT	CONVERTED FROM PDB (SEQRES) 6GLA
DE	Tyrosine-protein kinase JAK3
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.920
CC	R-Factor	0.228
FT	#SUB	9	 818 	GLU	B	110	 919 	ALA	A	Protein	S	1
FT	#SUB	11	 820 	ARG	B	110	 919 	ALA	A	Protein	S	4
FT	#SUB	82	 891 	TYR	B	109	 918 	ARG	A	Protein	S	1
FT	#SUB	82	 891 	TYR	B	214	1023 	TYR	A	Protein	S	1
FT	#SUB	82	 891 	TYR	B	256	1065 	ALA	A	Protein	S	2
FT	#SUB	83	 892 	GLY	B	109	 918 	ARG	A	Protein	B	5
FT	#SUB	84	 893 	PRO	B	109	 918 	ARG	A	Protein	A	5
FT	#SUB	84	 893 	PRO	B	216	1025 	ASP	A	Protein	A	3
FT	#SUB	85	 894 	GLY	B	216	1025 	ASP	A	Protein	B	3
FT	#SUB	85	 894 	GLY	B	218	1027 	SER	A	Protein	B	3
FT	#SUB	86	 895 	ARG	B	218	1027 	SER	A	Protein	B	1
FT	#SUB	86	 895 	ARG	B	227	1036 	ARG	A	Protein	S	1
FT	#HET	19	 828 	LEU	B	9	1201 	F4B	B	A	8
FT	#HET	21	 830 	LYS	B	11	1203 	EDO	B	B	3
FT	#HET	22	 831 	GLY	B	11	1203 	EDO	B	B	2
FT	#HET	25	 834 	GLY	B	11	1203 	EDO	B	B	3
FT	#HET	27	 836 	VAL	B	9	1201 	F4B	B	S	5
FT	#HET	44	 853 	ALA	B	9	1201 	F4B	B	S	3
FT	#HET	46	 855 	LYS	B	11	1203 	EDO	B	S	2
FT	#HET	75	 884 	VAL	B	9	1201 	F4B	B	S	1
FT	#HET	94	 903 	GLU	B	9	1201 	F4B	B	B	5
FT	#HET	95	 904 	TYR	B	9	1201 	F4B	B	A	5
FT	#HET	96	 905 	LEU	B	9	1201 	F4B	B	B	6
FT	#HET	100	 909 	CYS	B	9	1201 	F4B	B	S	8
FT	#HET	102	 911 	ARG	B	9	1201 	F4B	B	S	3
FT	#HET	103	 912 	ASP	B	9	1201 	F4B	B	S	6
FT	#HET	139	 948 	ARG	B	12	1204 	EDO	B	B	1
FT	#HET	144	 953 	ARG	B	9	1201 	F4B	B	A	9
FT	#HET	145	 954 	ASN	B	9	1201 	F4B	B	S	1
FT	#HET	147	 956 	LEU	B	9	1201 	F4B	B	S	12
FT	#HET	183	 992 	PHE	B	10	1202 	PHU	B	S	1
FT	#HET	184	 993 	TRP	B	12	1204 	EDO	B	B	1
FT	#HET	185	 994 	TYR	B	12	1204 	EDO	B	A	8
FT	#HET	186	 995 	ALA	B	12	1204 	EDO	B	A	4
FT	#HET	189	 998 	SER	B	12	1204 	EDO	B	S	3
FT	#HET	195	1004 	PHE	B	12	1204 	EDO	B	S	5
FT	#HET	199	1008 	SER	B	12	1204 	EDO	B	A	14
FT	#HET	200	1009 	ASP	B	12	1204 	EDO	B	A	5
FT	#HET	202	1011 	TRP	B	10	1202 	PHU	B	S	3
FT	#HET	203	1012 	SER	B	12	1204 	EDO	B	S	3
FT	#HET	221	1030 	PRO	B	10	1202 	PHU	B	B	1
FT	#HET	225	1034 	PHE	B	10	1202 	PHU	B	B	1
FT	#HET	228	1037 	MET	B	10	1202 	PHU	B	S	2
FT	#HET	245	1054 	LEU	B	10	1202 	PHU	B	S	3
FT	#HET	250	1059 	ARG	B	10	1202 	PHU	B	A	4
FT	#HET	251	1060 	LEU	B	10	1202 	PHU	B	A	20
FT	#HET	269	1078 	TRP	B	10	1202 	PHU	B	S	8
FT	DISORDER	1	3
FT	DISORDER	176	178
FT	DISORDER	230	231
CC	SEQUENCE	286 AA (ATOM);
CC	DPTIFEERHL KYISQLGKGN FGSVELCRYD PLGDNTGALV AVKQLQHSGP DQQRDFQREI
CC	QILKALHSDF IVKYRGVSYG PGRQSLRLVM EYLPSGCLRD FLQRHRARLD ASRLLLYSSQ
CC	ICKGMEYLGS RRCVHRALAA RNILVESEAH VKIADFGLAK LLPLDKDYYV VRQSPIFWYA
CC	PESLSDNIFS RQSDVWSFGV VLYELFTYCD KSCSPSAEFL RMMERDVPAL SRLLELLEEG
CC	QRLPAPPACP AEVHELMKLC WAPSPQDRPS FSALGPQLDM LWSGSR
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES SMQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	ATOM   ---DPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQH
CC	          ***********************************************
CC	SEQRES SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	ATOM   SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGC
CC	       **************************************************
CC	SEQRES LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	ATOM   LRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRALAARNILVES
CC	       **************************************************
CC	SEQRES EAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSD
CC	ATOM   EAHVKIADFGLAKLLPLDKDYYVVR---QSPIFWYAPESLSDNIFSRQSD
CC	       *************************   **********************
CC	SEQRES VWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR
CC	ATOM   VWSFGVVLYELFTYCDKSCSPSAEFLRMM--ERDVPALSRLLELLEEGQR
CC	       *****************************  *******************
CC	SEQRES LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	ATOM   LPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR
CC	       ********************************************
SQ	SEQUENCE	294 AA;      MW;         CN;
	SMQDPTIFEE RHLKYISQLG KGNFGSVELC RYDPLGDNTG ALVAVKQLQH SGPDQQRDFQ
	REIQILKALH SDFIVKYRGV SYGPGRQSLR LVMEYLPSGC LRDFLQRHRA RLDASRLLLY
	SSQICKGMEY LGSRRCVHRA LAARNILVES EAHVKIADFG LAKLLPLDKD YYVVREPGQS
	PIFWYAPESL SDNIFSRQSD VWSFGVVLYE LFTYCDKSCS PSAEFLRMMG SERDVPALSR
	LLELLEEGQR LPAPPACPAE VHELMKLCWA PSPQDRPSFS ALGPQLDMLW SGSR
//