ID 6F8RA STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F8R DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.830 CC R-Factor 0.188 FT #SUB 142 384 GLU A 163 405 LYS B Protein S 3 FT #SUB 144 386 ALA A 185 427 ARG B Protein B 2 FT #SUB 145 387 LEU A 159 401 ALA B Protein B 2 FT #SUB 145 387 LEU A 162 404 PHE B Protein S 1 FT #SUB 145 387 LEU A 163 405 LYS B Protein S 3 FT #SUB 145 387 LEU A 166 408 GLN B Protein S 1 FT #SUB 145 387 LEU A 185 427 ARG B Protein S 1 FT #SUB 146 388 MET A 146 388 MET B Protein S 3 FT #SUB 146 388 MET A 147 389 TYR B Protein A 6 FT #SUB 146 388 MET A 159 401 ALA B Protein B 1 FT #SUB 147 389 TYR A 146 388 MET B Protein S 6 FT #SUB 147 389 TYR A 147 389 TYR B Protein S 4 FT #SUB 148 390 ASN A 155 397 ASN B Protein S 7 FT #SUB 148 390 ASN A 158 400 LEU B Protein S 6 FT #SUB 148 390 ASN A 159 401 ALA B Protein S 1 FT #SUB 148 390 ASN A 185 427 ARG B Protein B 2 FT #SUB 148 390 ASN A 189 431 ILE B Protein B 2 FT #SUB 149 391 ASP A 185 427 ARG B Protein A 11 FT #SUB 155 397 ASN A 148 390 ASN B Protein A 6 FT #SUB 158 400 LEU A 148 390 ASN B Protein S 5 FT #SUB 159 401 ALA A 145 387 LEU B Protein A 2 FT #SUB 159 401 ALA A 146 388 MET B Protein S 1 FT #SUB 159 401 ALA A 148 390 ASN B Protein B 1 FT #SUB 162 404 PHE A 145 387 LEU B Protein S 1 FT #SUB 163 405 LYS A 145 387 LEU B Protein A 2 FT #SUB 166 408 GLN A 145 387 LEU B Protein S 1 FT #SUB 185 427 ARG A 144 386 ALA B Protein S 2 FT #SUB 185 427 ARG A 145 387 LEU B Protein S 1 FT #SUB 185 427 ARG A 148 390 ASN B Protein S 2 FT #SUB 185 427 ARG A 149 391 ASP B Protein S 11 FT #SUB 189 431 ILE A 148 390 ASN B Protein S 4 FT #HET 83 325 TYR A 1 601 CZK A S 13 FT #HET 84 326 HIS A 1 601 CZK A S 10 FT #HET 88 330 HIS A 5 605 ZN A S 3 FT #HET 124 366 HIS A 5 605 ZN A S 3 FT #HET 125 367 ASP A 2 602 MG A S 3 FT #HET 125 367 ASP A 5 605 ZN A S 3 FT #HET 132 374 SER A 1 601 CZK A A 11 FT #HET 148 390 ASN A 9 604 EDO B B 4 FT #HET 149 391 ASP A 9 604 EDO B S 3 FT #HET 175 417 ASN A 4 604 MG A S 3 FT #HET 197 439 MET A 1 601 CZK A S 3 FT #HET 225 467 ASP A 3 603 MG A S 3 FT #HET 229 471 ASP A 3 603 MG A S 3 FT #HET 242 484 ASP A 5 605 ZN A S 3 FT #HET 245 487 ASN A 1 601 CZK A S 9 FT #HET 253 495 TYR A 1 601 CZK A S 2 FT #HET 256 498 TRP A 1 601 CZK A A 4 FT #HET 257 499 THR A 1 601 CZK A A 9 FT #HET 260 502 ILE A 1 601 CZK A S 12 FT #HET 261 503 MET A 1 601 CZK A S 3 FT #HET 264 506 PHE A 1 601 CZK A S 21 FT #HET 267 509 GLN A 1 601 CZK A S 3 FT #HET 279 521 SER A 1 601 CZK A S 3 FT #HET 280 522 PRO A 1 601 CZK A B 2 FT #HET 281 523 MET A 1 601 CZK A S 10 FT #HET 282 524 CYS A 1 601 CZK A S 3 FT #HET 292 534 SER A 1 601 CZK A A 9 FT #HET 293 535 GLN A 1 601 CZK A A 16 FT #HET 296 538 PHE A 1 601 CZK A S 22 FT DISORDER 1 13 FT DISORDER 336 343 CC SEQUENCE 322 AA (ATOM); CC DVLAKELEDV NKWGLHVFRI AELSGNRPLT VIMHTIFQER DLLKTFKIPV DTLITYLMTL CC EDHYHADVAY HNNIHAADVV QSTHVLLSTP ALEAVFTDLE ILAAIFASAI HDVDHPGVSN CC QFLINTNSEL ALMYNDSSVL ENHHLAVGFK LLQEENCDIF QNLTKKQRQS LRKMVIDIVL CC ATDMSKHMNL LADLKTMVET KKVTSSGVLL LDNYSDRIQV LQNMVHCADL SNPTKPLQLY CC RQWTDRIMEE FFRQGDRERE RGMEISPMCD KHNASVEKSQ VGFIDYIVHP LWETWADLVH CC PDAQDILDTL EDNREWYQST IP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------------DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP-------- CC *********************************** SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH // ID 6F8RB STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F8R DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.830 CC R-Factor 0.188 FT #SUB 144 386 ALA B 185 427 ARG A Protein B 2 FT #SUB 145 387 LEU B 159 401 ALA A Protein B 2 FT #SUB 145 387 LEU B 162 404 PHE A Protein S 1 FT #SUB 145 387 LEU B 163 405 LYS A Protein S 2 FT #SUB 145 387 LEU B 166 408 GLN A Protein S 1 FT #SUB 145 387 LEU B 185 427 ARG A Protein B 1 FT #SUB 146 388 MET B 146 388 MET A Protein S 3 FT #SUB 146 388 MET B 147 389 TYR A Protein A 6 FT #SUB 146 388 MET B 159 401 ALA A Protein B 1 FT #SUB 147 389 TYR B 146 388 MET A Protein S 6 FT #SUB 147 389 TYR B 147 389 TYR A Protein S 4 FT #SUB 148 390 ASN B 155 397 ASN A Protein S 6 FT #SUB 148 390 ASN B 158 400 LEU A Protein S 5 FT #SUB 148 390 ASN B 159 401 ALA A Protein S 1 FT #SUB 148 390 ASN B 185 427 ARG A Protein B 2 FT #SUB 148 390 ASN B 189 431 ILE A Protein A 4 FT #SUB 149 391 ASP B 185 427 ARG A Protein A 11 FT #SUB 155 397 ASN B 148 390 ASN A Protein A 7 FT #SUB 158 400 LEU B 148 390 ASN A Protein A 6 FT #SUB 159 401 ALA B 145 387 LEU A Protein A 2 FT #SUB 159 401 ALA B 146 388 MET A Protein S 1 FT #SUB 159 401 ALA B 148 390 ASN A Protein B 1 FT #SUB 162 404 PHE B 145 387 LEU A Protein S 1 FT #SUB 163 405 LYS B 142 384 GLU A Protein S 3 FT #SUB 163 405 LYS B 145 387 LEU A Protein A 3 FT #SUB 166 408 GLN B 145 387 LEU A Protein S 1 FT #SUB 185 427 ARG B 144 386 ALA A Protein S 2 FT #SUB 185 427 ARG B 145 387 LEU A Protein S 1 FT #SUB 185 427 ARG B 148 390 ASN A Protein S 2 FT #SUB 185 427 ARG B 149 391 ASP A Protein S 11 FT #SUB 189 431 ILE B 148 390 ASN A Protein S 2 FT #HET 83 325 TYR B 6 601 CZK B S 11 FT #HET 88 330 HIS B 8 603 ZN B S 3 FT #HET 124 366 HIS B 8 603 ZN B S 3 FT #HET 125 367 ASP B 7 602 MG B S 3 FT #HET 125 367 ASP B 8 603 ZN B S 3 FT #HET 186 428 LYS B 9 604 EDO B A 14 FT #HET 189 431 ILE B 9 604 EDO B S 8 FT #HET 190 432 ASP B 9 604 EDO B S 11 FT #HET 197 439 MET B 6 601 CZK B S 6 FT #HET 242 484 ASP B 8 603 ZN B S 3 FT #HET 245 487 ASN B 6 601 CZK B S 9 FT #HET 253 495 TYR B 6 601 CZK B S 2 FT #HET 256 498 TRP B 6 601 CZK B A 11 FT #HET 257 499 THR B 6 601 CZK B A 9 FT #HET 260 502 ILE B 6 601 CZK B S 10 FT #HET 261 503 MET B 6 601 CZK B S 8 FT #HET 264 506 PHE B 6 601 CZK B S 15 FT #HET 281 523 MET B 6 601 CZK B S 24 FT #HET 292 534 SER B 6 601 CZK B A 9 FT #HET 293 535 GLN B 6 601 CZK B A 19 FT #HET 295 537 GLY B 6 601 CZK B B 1 FT #HET 296 538 PHE B 6 601 CZK B A 37 FT #HET 300 542 ILE B 6 601 CZK B S 7 FT DISORDER 1 13 FT DISORDER 338 343 CC SEQUENCE 324 AA (ATOM); CC DVLAKELEDV NKWGLHVFRI AELSGNRPLT VIMHTIFQER DLLKTFKIPV DTLITYLMTL CC EDHYHADVAY HNNIHAADVV QSTHVLLSTP ALEAVFTDLE ILAAIFASAI HDVDHPGVSN CC QFLINTNSEL ALMYNDSSVL ENHHLAVGFK LLQEENCDIF QNLTKKQRQS LRKMVIDIVL CC ATDMSKHMNL LADLKTMVET KKVTSSGVLL LDNYSDRIQV LQNMVHCADL SNPTKPLQLY CC RQWTDRIMEE FFRQGDRERE RGMEISPMCD KHNASVEKSQ VGFIDYIVHP LWETWADLVH CC PDAQDILDTL EDNREWYQST IPQA CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------------DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQA------ CC ************************************* SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH //