ID 6F6UA STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F6U DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.830 CC R-Factor 0.187 FT #SUB 142 384 GLU A 163 405 LYS B Protein S 3 FT #SUB 142 384 GLU A 166 408 GLN B Protein S 2 FT #SUB 144 386 ALA A 185 427 ARG B Protein B 1 FT #SUB 145 387 LEU A 159 401 ALA B Protein B 2 FT #SUB 145 387 LEU A 162 404 PHE B Protein S 1 FT #SUB 145 387 LEU A 163 405 LYS B Protein S 2 FT #SUB 145 387 LEU A 166 408 GLN B Protein S 1 FT #SUB 146 388 MET A 146 388 MET B Protein S 2 FT #SUB 146 388 MET A 147 389 TYR B Protein A 6 FT #SUB 146 388 MET A 159 401 ALA B Protein B 1 FT #SUB 147 389 TYR A 146 388 MET B Protein S 6 FT #SUB 147 389 TYR A 147 389 TYR B Protein S 4 FT #SUB 148 390 ASN A 155 397 ASN B Protein S 7 FT #SUB 148 390 ASN A 158 400 LEU B Protein S 7 FT #SUB 148 390 ASN A 159 401 ALA B Protein S 1 FT #SUB 148 390 ASN A 185 427 ARG B Protein B 2 FT #SUB 148 390 ASN A 189 431 ILE B Protein A 3 FT #SUB 149 391 ASP A 185 427 ARG B Protein A 11 FT #SUB 155 397 ASN A 148 390 ASN B Protein A 7 FT #SUB 158 400 LEU A 148 390 ASN B Protein A 6 FT #SUB 159 401 ALA A 145 387 LEU B Protein A 2 FT #SUB 159 401 ALA A 146 388 MET B Protein S 1 FT #SUB 159 401 ALA A 148 390 ASN B Protein B 1 FT #SUB 162 404 PHE A 145 387 LEU B Protein S 1 FT #SUB 163 405 LYS A 145 387 LEU B Protein A 3 FT #SUB 166 408 GLN A 145 387 LEU B Protein S 1 FT #SUB 185 427 ARG A 144 386 ALA B Protein S 2 FT #SUB 185 427 ARG A 148 390 ASN B Protein S 2 FT #SUB 185 427 ARG A 149 391 ASP B Protein S 11 FT #SUB 189 431 ILE A 148 390 ASN B Protein S 4 FT #HET 22 264 ASP A 3 603 MG A S 2 FT #HET 83 325 TYR A 4 604 CV8 A S 9 FT #HET 88 330 HIS A 2 602 ZN A S 3 FT #HET 124 366 HIS A 2 602 ZN A S 3 FT #HET 125 367 ASP A 1 601 MG A S 3 FT #HET 125 367 ASP A 2 602 ZN A S 3 FT #HET 127 369 ASP A 5 605 GOL A S 1 FT #HET 132 374 SER A 4 604 CV8 A A 11 FT #HET 156 398 HIS A 5 605 GOL A S 8 FT #HET 159 401 ALA A 5 605 GOL A A 3 FT #HET 160 402 VAL A 5 605 GOL A A 12 FT #HET 163 405 LYS A 5 605 GOL A S 1 FT #HET 197 439 MET A 4 604 CV8 A S 5 FT #HET 242 484 ASP A 2 602 ZN A S 3 FT #HET 245 487 ASN A 4 604 CV8 A S 9 FT #HET 253 495 TYR A 4 604 CV8 A S 3 FT #HET 256 498 TRP A 4 604 CV8 A A 4 FT #HET 257 499 THR A 4 604 CV8 A A 11 FT #HET 260 502 ILE A 4 604 CV8 A S 10 FT #HET 261 503 MET A 4 604 CV8 A S 3 FT #HET 264 506 PHE A 4 604 CV8 A S 27 FT #HET 267 509 GLN A 4 604 CV8 A S 9 FT #HET 280 522 PRO A 4 604 CV8 A A 3 FT #HET 281 523 MET A 4 604 CV8 A S 10 FT #HET 282 524 CYS A 4 604 CV8 A S 4 FT #HET 292 534 SER A 4 604 CV8 A A 7 FT #HET 293 535 GLN A 4 604 CV8 A A 20 FT #HET 296 538 PHE A 4 604 CV8 A S 25 FT DISORDER 1 7 FT DISORDER 336 343 CC SEQUENCE 328 AA (ATOM); CC VKTEQEDVLA KELEDVNKWG LHVFRIAELS GNRPLTVIMH TIFQERDLLK TFKIPVDTLI CC TYLMTLEDHY HADVAYHNNI HAADVVQSTH VLLSTPALEA VFTDLEILAA IFASAIHDVD CC HPGVSNQFLI NTNSELALMY NDSSVLENHH LAVGFKLLQE ENCDIFQNLT KKQRQSLRKM CC VIDIVLATDM SKHMNLLADL KTMVETKKVT SSGVLLLDNY SDRIQVLQNM VHCADLSNPT CC KPLQLYRQWT DRIMEEFFRQ GDRERERGME ISPMCDKHNA SVEKSQVGFI DYIVHPLWET CC WADLVHPDAQ DILDTLEDNR EWYQSTIP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ******************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP-------- CC *********************************** SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH // ID 6F6UB STANDARD; PRT; 343 AA. DT CONVERTED FROM PDB (SEQRES) 6F6U DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.830 CC R-Factor 0.187 FT #SUB 144 386 ALA B 185 427 ARG A Protein B 2 FT #SUB 145 387 LEU B 159 401 ALA A Protein B 2 FT #SUB 145 387 LEU B 162 404 PHE A Protein S 1 FT #SUB 145 387 LEU B 163 405 LYS A Protein S 3 FT #SUB 145 387 LEU B 166 408 GLN A Protein S 1 FT #SUB 146 388 MET B 146 388 MET A Protein S 2 FT #SUB 146 388 MET B 147 389 TYR A Protein A 6 FT #SUB 146 388 MET B 159 401 ALA A Protein B 1 FT #SUB 147 389 TYR B 146 388 MET A Protein S 6 FT #SUB 147 389 TYR B 147 389 TYR A Protein S 4 FT #SUB 148 390 ASN B 155 397 ASN A Protein S 7 FT #SUB 148 390 ASN B 158 400 LEU A Protein S 6 FT #SUB 148 390 ASN B 159 401 ALA A Protein S 1 FT #SUB 148 390 ASN B 185 427 ARG A Protein B 2 FT #SUB 148 390 ASN B 189 431 ILE A Protein A 4 FT #SUB 149 391 ASP B 185 427 ARG A Protein A 11 FT #SUB 155 397 ASN B 148 390 ASN A Protein A 7 FT #SUB 158 400 LEU B 148 390 ASN A Protein A 7 FT #SUB 159 401 ALA B 145 387 LEU A Protein A 2 FT #SUB 159 401 ALA B 146 388 MET A Protein S 1 FT #SUB 159 401 ALA B 148 390 ASN A Protein B 1 FT #SUB 162 404 PHE B 145 387 LEU A Protein S 1 FT #SUB 163 405 LYS B 142 384 GLU A Protein S 3 FT #SUB 163 405 LYS B 145 387 LEU A Protein A 2 FT #SUB 166 408 GLN B 142 384 GLU A Protein S 2 FT #SUB 166 408 GLN B 145 387 LEU A Protein S 1 FT #SUB 185 427 ARG B 144 386 ALA A Protein S 1 FT #SUB 185 427 ARG B 148 390 ASN A Protein S 2 FT #SUB 185 427 ARG B 149 391 ASP A Protein S 11 FT #SUB 189 431 ILE B 148 390 ASN A Protein S 3 FT #HET 83 325 TYR B 8 603 CV8 B S 10 FT #HET 88 330 HIS B 7 602 ZN B S 3 FT #HET 124 366 HIS B 7 602 ZN B S 3 FT #HET 125 367 ASP B 6 601 MG B S 3 FT #HET 125 367 ASP B 7 602 ZN B S 3 FT #HET 132 374 SER B 8 603 CV8 B S 5 FT #HET 146 388 MET B 5 605 GOL A S 2 FT #HET 197 439 MET B 8 603 CV8 B S 5 FT #HET 242 484 ASP B 7 602 ZN B S 3 FT #HET 245 487 ASN B 8 603 CV8 B S 9 FT #HET 253 495 TYR B 8 603 CV8 B S 2 FT #HET 256 498 TRP B 8 603 CV8 B A 9 FT #HET 257 499 THR B 8 603 CV8 B A 13 FT #HET 260 502 ILE B 8 603 CV8 B S 14 FT #HET 261 503 MET B 8 603 CV8 B S 5 FT #HET 264 506 PHE B 8 603 CV8 B S 26 FT #HET 279 521 SER B 8 603 CV8 B S 1 FT #HET 281 523 MET B 8 603 CV8 B S 9 FT #HET 282 524 CYS B 8 603 CV8 B S 1 FT #HET 292 534 SER B 8 603 CV8 B A 10 FT #HET 293 535 GLN B 8 603 CV8 B A 22 FT #HET 296 538 PHE B 8 603 CV8 B S 24 FT DISORDER 1 13 FT DISORDER 338 343 CC SEQUENCE 324 AA (ATOM); CC DVLAKELEDV NKWGLHVFRI AELSGNRPLT VIMHTIFQER DLLKTFKIPV DTLITYLMTL CC EDHYHADVAY HNNIHAADVV QSTHVLLSTP ALEAVFTDLE ILAAIFASAI HDVDHPGVSN CC QFLINTNSEL ALMYNDSSVL ENHHLAVGFK LLQEENCDIF QNLTKKQRQS LRKMVIDIVL CC ATDMSKHMNL LADLKTMVET KKVTSSGVLL LDNYSDRIQV LQNMVHCADL SNPTKPLQLY CC RQWTDRIMEE FFRQGDRERE RGMEISPMCD KHNASVEKSQ VGFIDYIVHP LWETWADLVH CC PDAQDILDTL EDNREWYQST IPQA CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ATOM -------------DVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF CC ************************************* CC SEQRES QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ATOM QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLL CC ************************************************** CC SEQRES STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ATOM STPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDS CC ************************************************** CC SEQRES SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ATOM SVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKH CC ************************************************** CC SEQRES MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ATOM MNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL CC ************************************************** CC SEQRES QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ATOM QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYI CC ************************************************** CC SEQRES VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQAHHHHHH CC ATOM VHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQA------ CC ************************************* SQ SEQUENCE 343 AA; MW; CN; MSIPRFGVKT EQEDVLAKEL EDVNKWGLHV FRIAELSGNR PLTVIMHTIF QERDLLKTFK IPVDTLITYL MTLEDHYHAD VAYHNNIHAA DVVQSTHVLL STPALEAVFT DLEILAAIFA SAIHDVDHPG VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQEENC DIFQNLTKKQ RQSLRKMVID IVLATDMSKH MNLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLQNMVHC ADLSNPTKPL QLYRQWTDRI MEEFFRQGDR ERERGMEISP MCDKHNASVE KSQVGFIDYI VHPLWETWAD LVHPDAQDIL DTLEDNREWY QSTIPQAHHH HHH //