ID 6EDSA STANDARD; PRT; 978 AA. DT CONVERTED FROM PDB (SEQRES) 6EDS DE Insulin-degrading enzyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.180 CC R-Factor 0.179 FT #SUB 78 119 LYS A 486 527 LYS B Protein A 4 FT #SUB 79 120 LYS A 368 409 TRP B Protein B 1 FT #SUB 79 120 LYS A 486 527 LYS B Protein S 2 FT #SUB 80 121 TYR A 367 408 GLU B Protein S 3 FT #SUB 80 121 TYR A 368 409 TRP B Protein S 6 FT #SUB 81 122 PRO A 486 527 LYS B Protein S 4 FT #SUB 85 126 GLU A 371 412 GLN B Protein S 3 FT #SUB 89 130 PHE A 367 408 GLU B Protein S 1 FT #SUB 119 160 GLY A 367 408 GLU B Protein B 1 FT #SUB 123 164 ARG A 367 408 GLU B Protein S 8 FT #SUB 123 164 ARG A 371 412 GLN B Protein S 3 FT #SUB 232 273 LYS A 365 406 PRO B Protein S 1 FT #SUB 834 875 GLU A 14 55 THR B Protein B 3 FT #SUB 835 876 ASP A 15 56 LYS B Protein S 1 FT #SUB 835 876 ASP A 17 58 PRO B Protein S 1 FT #SUB 836 877 MET A 14 55 THR B Protein B 1 FT #SUB 837 878 THR A 414 455 LEU B Protein S 1 FT #SUB 837 878 THR A 416 457 GLU B Protein S 5 FT #SUB 838 879 GLU A 407 448 GLU B Protein S 3 FT #SUB 839 880 GLU A 286 327 LYS B Protein S 3 FT #SUB 839 880 GLU A 407 448 GLU B Protein S 3 FT #SUB 839 880 GLU A 416 457 GLU B Protein S 9 FT #SUB 843 884 LYS A 416 457 GLU B Protein S 1 FT #SUB 892 933 LYS A 14 55 THR B Protein S 1 FT #SUB 893 934 GLU A 11 52 ASN B Protein S 5 FT #SUB 55 96 SER A 24 24 GLN C Protein S 1 FT #SUB 67 108 HIS A 24 24 GLN C Protein S 3 FT #SUB 67 108 HIS A 25 25 TRP C Protein S 1 FT #SUB 70 111 GLN A 24 24 GLN C Protein S 1 FT #SUB 70 111 GLN A 25 25 TRP C Protein S 1 FT #SUB 70 111 GLN A 26 26 LEU C Protein S 3 FT #SUB 71 112 HIS A 25 25 TRP C Protein S 1 FT #SUB 71 112 HIS A 26 26 LEU C Protein A 6 FT #SUB 74 115 PHE A 26 26 LEU C Protein S 4 FT #SUB 97 138 SER A 27 27 MET C Protein B 1 FT #SUB 98 139 ASN A 25 25 TRP C Protein S 1 FT #SUB 98 139 ASN A 26 26 LEU C Protein S 3 FT #SUB 98 139 ASN A 27 27 MET C Protein S 9 FT #SUB 99 140 ALA A 25 25 TRP C Protein B 3 FT #SUB 99 140 ALA A 26 26 LEU C Protein B 4 FT #SUB 100 141 PHE A 23 23 VAL C Protein S 2 FT #SUB 100 141 PHE A 24 24 GLN C Protein A 3 FT #SUB 100 141 PHE A 25 25 TRP C Protein S 2 FT #SUB 101 142 THR A 23 23 VAL C Protein B 1 FT #SUB 101 142 THR A 24 24 GLN C Protein A 6 FT #SUB 102 143 SER A 23 23 VAL C Protein S 1 FT #SUB 109 150 TYR A 25 25 TRP C Protein S 2 FT #SUB 148 189 GLU A 24 24 GLN C Protein S 1 FT #SUB 148 189 GLU A 25 25 TRP C Protein S 6 FT #SUB 157 198 ALA A 22 22 PHE C Protein S 1 FT #SUB 158 199 TRP A 22 22 PHE C Protein S 7 FT #SUB 158 199 TRP A 24 24 GLN C Protein S 1 FT #SUB 161 202 PHE A 22 22 PHE C Protein S 2 FT #SUB 291 332 HIS A 2 2 SER C Protein S 1 FT #SUB 294 335 GLY A 2 2 SER C Protein B 3 FT #SUB 298 339 GLY A 1 1 HIS C Protein B 6 FT #SUB 300 341 GLU A 1 1 HIS C Protein S 5 FT #SUB 318 359 LEU A 1 1 HIS C Protein B 1 FT #SUB 319 360 VAL A 1 1 HIS C Protein A 7 FT #SUB 319 360 VAL A 3 3 GLN C Protein S 1 FT #SUB 320 361 GLY A 1 1 HIS C Protein B 2 FT #SUB 320 361 GLY A 2 2 SER C Protein B 4 FT #SUB 320 361 GLY A 3 3 GLN C Protein B 1 FT #SUB 321 362 GLY A 3 3 GLN C Protein B 1 FT #SUB 322 363 GLN A 3 3 GLN C Protein B 2 FT #SUB 322 363 GLN A 4 4 GLY C Protein B 2 FT #SUB 322 363 GLN A 5 5 THR C Protein A 3 FT #SUB 323 364 LYS A 5 5 THR C Protein B 2 FT #SUB 324 365 GLU A 5 5 THR C Protein A 9 FT #SUB 568 609 TYR A 1 1 HIS C Protein S 4 FT #SUB 779 820 PHE A 27 27 MET C Protein S 2 FT #SUB 779 820 PHE A 28 28 ASN C Protein S 2 FT #SUB 783 824 ARG A 26 26 LEU C Protein S 3 FT #SUB 783 824 ARG A 27 27 MET C Protein S 1 FT #SUB 790 831 TYR A 25 25 TRP C Protein S 4 FT #SUB 790 831 TYR A 26 26 LEU C Protein S 5 FT #SUB 790 831 TYR A 27 27 MET C Protein S 5 FT #SUB 790 831 TYR A 28 28 ASN C Protein A 3 FT #SUB 791 832 ILE A 28 28 ASN C Protein B 1 FT #SUB 792 833 VAL A 28 28 ASN C Protein B 2 FT #HET 157 198 ALA A 1 1101 J22 A A 5 FT #HET 160 201 LEU A 1 1101 J22 A A 10 FT #HET 161 202 PHE A 1 1101 J22 A A 15 FT #HET 163 204 LEU A 1 1101 J22 A A 9 FT #HET 164 205 GLU A 1 1101 J22 A A 23 FT #HET 167 208 THR A 1 1101 J22 A S 6 FT #HET 261 302 TYR A 1 1101 J22 A S 23 FT #HET 263 304 ILE A 1 1101 J22 A S 2 FT #HET 273 314 TYR A 1 1101 J22 A S 22 FT #HET 275 316 THR A 1 1101 J22 A S 6 FT #HET 319 360 VAL A 1 1101 J22 A A 7 FT #HET 320 361 GLY A 1 1101 J22 A B 6 FT #HET 321 362 GLY A 1 1101 J22 A B 4 FT #HET 322 363 GLN A 1 1101 J22 A B 3 FT #HET 323 364 LYS A 1 1101 J22 A A 17 FT #HET 333 374 ILE A 1 1101 J22 A A 10 FT #HET 335 376 ASN A 1 1101 J22 A S 6 FT #HET 436 477 ARG A 1 1101 J22 A A 10 FT #HET 437 478 VAL A 1 1101 J22 A B 2 FT #HET 438 479 ALA A 1 1101 J22 A S 8 FT #HET 488 529 GLU A 4 1104 DIO A A 8 FT #HET 489 530 PHE A 4 1104 DIO A A 19 FT #HET 497 538 LEU A 3 1103 PEG A S 6 FT #HET 533 574 LEU A 3 1103 PEG A S 1 FT #HET 566 607 TYR A 4 1104 DIO A S 4 FT #HET 594 635 ASN A 3 1103 PEG A A 20 FT #HET 597 638 GLN A 3 1103 PEG A S 6 FT #HET 598 639 PRO A 3 1103 PEG A S 6 FT #HET 599 640 ILE A 4 1104 DIO A S 6 FT #HET 691 732 ASN A 3 1103 PEG A B 5 FT #HET 692 733 ILE A 3 1103 PEG A A 17 FT #HET 693 734 THR A 3 1103 PEG A A 2 FT #HET 696 737 ALA A 3 1103 PEG A S 2 FT #HET 700 741 ILE A 3 1103 PEG A S 2 FT #HET 759 800 GLN A 2 1102 EPE A S 13 FT #HET 764 805 ASN A 2 1102 EPE A S 1 FT #HET 768 809 GLU A 2 1102 EPE A S 2 FT #HET 798 839 ARG A 2 1102 EPE A A 11 FT #HET 799 840 ALA A 2 1102 EPE A B 3 FT #HET 800 841 ASN A 2 1102 EPE A B 3 FT #HET 801 842 GLY A 2 1102 EPE A B 2 FT #HET 852 893 ARG A 2 1102 EPE A S 5 FT #HET 868 909 GLY A 2 1102 EPE A B 4 FT #HET 869 910 GLU A 2 1102 EPE A S 2 FT #HET 872 913 SER A 2 1102 EPE A S 8 FT #HET 874 915 GLN A 2 1102 EPE A S 4 FT #HET 879 920 ARG A 2 1102 EPE A S 11 FT DISORDER 1 1 FT DISORDER 927 936 FT DISORDER 971 978 CC SEQUENCE 959 AA (ATOM); CC NNPAIKRIGN HITKSPEDKR EYRGLELANG IKVLLISDPT TDKSSAALDV HIGSLSDPPN CC IAGLSHFLQH MLFLGTKKYP KENEYSQFLS EHAGSSNAFT SGEHTNYYFD VSHEHLEGAL CC DRFAQFFLSP LFDESAKDRE VNAVDSEHEK NVMNDAWRLF QLEKATGNPK HPFSKFGTGN CC KYTLETRPNQ EGIDVRQELL KFHSAYYSSN LMAVVVLGRE SLDDLTNLVV KLFSEVENKN CC VPLPEFPEHP FQEEHLKQLY KIVPIKDIRN LYVTFPIPDL QKYYKSNPGH YLGHLIGHEG CC PGSLLSELKS KGWVNTLVGG QKEGARGFMF FIINVDLTEE GLLHVEDIIL HMFQYIQKLR CC AEGPQEWVFQ ELKDLNAVAF RFKDKERPRG YTSKIAGILH YYPLEEVLTA EYLLEEFRPD CC LIEMVLDKLR PENVRVAIVS KSFEGKTDRT EEWYGTQYKQ EAIPDEVIKK WQNADLNGKF CC KLPTKNEFIP TNFEILPLEK EATPYPALIK DTAMSKLWFK QDDKFFLPKA NLNFEFFSPF CC AYVDPLHSNM AYLYLELLKD SLNEYAYAAE LAGLSYDLQN TIYGMYLSVK GYNDKQPILL CC KKIIEKMATF EIDEKRFEII KEAYMRSLNN FRAEQPHQHA MYYLRLLMTE VAWTKDELKE CC ALDDVTLPRL KAFIPQLLSR LHIEALLHGN ITKQAALGIM QMVEDTLIEH AHTKPLLPSQ CC LVRYREVQLP DRGWFVYQQR NEVHNNSGIE IYYQTDMQST SENMFLELFA QIISEPAFNT CC LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR VEAFLITMEK SIEDMTEEAF CC QKHIQALAIR RLDKPKKLSA ESAKYWGEII SQQYNFDRDN TEVAYLKTLT KEDIIKFYKE CC MLAVDAPRRH KVSVHVLARE MDSNPINLSQ APALPQPEVI QNMTEFKRGL PLFPLVKPH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALD CC ATOM -NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALD CC ************************************************* CC SEQRES VHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAF CC ATOM VHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAF CC ************************************************** CC SEQRES TSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHE CC ATOM TSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHE CC ************************************************** CC SEQRES KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQEL CC ATOM KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQEL CC ************************************************** CC SEQRES LKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH CC ATOM LKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH CC ************************************************** CC SEQRES PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE CC ATOM PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE CC ************************************************** CC SEQRES GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII CC ATOM GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII CC ************************************************** CC SEQRES LHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGIL CC ATOM LHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGIL CC ************************************************** CC SEQRES HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR CC ATOM HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR CC ************************************************** CC SEQRES TEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLE CC ATOM TEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLE CC ************************************************** CC SEQRES KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSN CC ATOM KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSN CC ************************************************** CC SEQRES MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL CC ATOM MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL CC ************************************************** CC SEQRES LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMT CC ATOM LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMT CC ************************************************** CC SEQRES EVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGI CC ATOM EVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGI CC ************************************************** CC SEQRES MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGI CC ATOM MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGI CC ************************************************** CC SEQRES EIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRAN CC ATOM EIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRAN CC ************************************************** CC SEQRES GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI CC ATOM GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI CC ************************************************** CC SEQRES RRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK CC ATOM RRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK CC ************************************************** CC SEQRES EMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEV CC ATOM EMLAVDAPRRHKVSVHVLAREMDSNP----------INLSQAPALPQPEV CC ************************** ************** CC SEQRES IQNMTEFKRGLPLFPLVKPHINFMAAKL CC ATOM IQNMTEFKRGLPLFPLVKPH-------- CC ******************** SQ SEQUENCE 978 AA; MW; CN; MNNPAIKRIG NHITKSPEDK REYRGLELAN GIKVLLISDP TTDKSSAALD VHIGSLSDPP NIAGLSHFLQ HMLFLGTKKY PKENEYSQFL SEHAGSSNAF TSGEHTNYYF DVSHEHLEGA LDRFAQFFLS PLFDESAKDR EVNAVDSEHE KNVMNDAWRL FQLEKATGNP KHPFSKFGTG NKYTLETRPN QEGIDVRQEL LKFHSAYYSS NLMAVVVLGR ESLDDLTNLV VKLFSEVENK NVPLPEFPEH PFQEEHLKQL YKIVPIKDIR NLYVTFPIPD LQKYYKSNPG HYLGHLIGHE GPGSLLSELK SKGWVNTLVG GQKEGARGFM FFIINVDLTE EGLLHVEDII LHMFQYIQKL RAEGPQEWVF QELKDLNAVA FRFKDKERPR GYTSKIAGIL HYYPLEEVLT AEYLLEEFRP DLIEMVLDKL RPENVRVAIV SKSFEGKTDR TEEWYGTQYK QEAIPDEVIK KWQNADLNGK FKLPTKNEFI PTNFEILPLE KEATPYPALI KDTAMSKLWF KQDDKFFLPK ANLNFEFFSP FAYVDPLHSN MAYLYLELLK DSLNEYAYAA ELAGLSYDLQ NTIYGMYLSV KGYNDKQPIL LKKIIEKMAT FEIDEKRFEI IKEAYMRSLN NFRAEQPHQH AMYYLRLLMT EVAWTKDELK EALDDVTLPR LKAFIPQLLS RLHIEALLHG NITKQAALGI MQMVEDTLIE HAHTKPLLPS QLVRYREVQL PDRGWFVYQQ RNEVHNNSGI EIYYQTDMQS TSENMFLELF AQIISEPAFN TLRTKEQLGY IVFSGPRRAN GIQGLRFIIQ SEKPPHYLES RVEAFLITME KSIEDMTEEA FQKHIQALAI RRLDKPKKLS AESAKYWGEI ISQQYNFDRD NTEVAYLKTL TKEDIIKFYK EMLAVDAPRR HKVSVHVLAR EMDSNPVVGE FPAQNDINLS QAPALPQPEV IQNMTEFKRG LPLFPLVKPH INFMAAKL // ID 6EDSB STANDARD; PRT; 978 AA. DT CONVERTED FROM PDB (SEQRES) 6EDS DE Insulin-degrading enzyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.180 CC R-Factor 0.179 FT #SUB 11 52 ASN B 893 934 GLU A Protein S 5 FT #SUB 14 55 THR B 834 875 GLU A Protein A 3 FT #SUB 14 55 THR B 836 877 MET A Protein S 1 FT #SUB 14 55 THR B 892 933 LYS A Protein S 1 FT #SUB 15 56 LYS B 835 876 ASP A Protein B 1 FT #SUB 17 58 PRO B 835 876 ASP A Protein S 1 FT #SUB 286 327 LYS B 839 880 GLU A Protein S 3 FT #SUB 365 406 PRO B 232 273 LYS A Protein B 1 FT #SUB 367 408 GLU B 80 121 TYR A Protein A 3 FT #SUB 367 408 GLU B 89 130 PHE A Protein S 1 FT #SUB 367 408 GLU B 119 160 GLY A Protein S 1 FT #SUB 367 408 GLU B 123 164 ARG A Protein S 8 FT #SUB 368 409 TRP B 79 120 LYS A Protein S 1 FT #SUB 368 409 TRP B 80 121 TYR A Protein A 6 FT #SUB 371 412 GLN B 85 126 GLU A Protein S 3 FT #SUB 371 412 GLN B 123 164 ARG A Protein S 3 FT #SUB 407 448 GLU B 838 879 GLU A Protein S 3 FT #SUB 407 448 GLU B 839 880 GLU A Protein S 3 FT #SUB 414 455 LEU B 837 878 THR A Protein S 1 FT #SUB 416 457 GLU B 837 878 THR A Protein S 5 FT #SUB 416 457 GLU B 839 880 GLU A Protein S 9 FT #SUB 416 457 GLU B 843 884 LYS A Protein B 1 FT #SUB 486 527 LYS B 78 119 LYS A Protein S 4 FT #SUB 486 527 LYS B 79 120 LYS A Protein A 2 FT #SUB 486 527 LYS B 81 122 PRO A Protein S 4 FT #SUB 67 108 HIS B 24 24 GLN D Protein S 3 FT #SUB 70 111 GLN B 24 24 GLN D Protein S 1 FT #SUB 70 111 GLN B 26 26 LEU D Protein S 3 FT #SUB 71 112 HIS B 26 26 LEU D Protein S 6 FT #SUB 74 115 PHE B 26 26 LEU D Protein S 6 FT #SUB 97 138 SER B 27 27 MET D Protein B 1 FT #SUB 98 139 ASN B 25 25 TRP D Protein S 2 FT #SUB 98 139 ASN B 26 26 LEU D Protein S 2 FT #SUB 98 139 ASN B 27 27 MET D Protein S 8 FT #SUB 99 140 ALA B 24 24 GLN D Protein B 1 FT #SUB 99 140 ALA B 25 25 TRP D Protein B 3 FT #SUB 99 140 ALA B 26 26 LEU D Protein B 2 FT #SUB 100 141 PHE B 23 23 VAL D Protein S 1 FT #SUB 100 141 PHE B 24 24 GLN D Protein A 3 FT #SUB 100 141 PHE B 25 25 TRP D Protein S 3 FT #SUB 101 142 THR B 22 22 PHE D Protein B 1 FT #SUB 101 142 THR B 23 23 VAL D Protein B 1 FT #SUB 101 142 THR B 24 24 GLN D Protein A 8 FT #SUB 109 150 TYR B 25 25 TRP D Protein S 2 FT #SUB 148 189 GLU B 24 24 GLN D Protein S 3 FT #SUB 148 189 GLU B 25 25 TRP D Protein S 4 FT #SUB 158 199 TRP B 22 22 PHE D Protein S 6 FT #SUB 158 199 TRP B 24 24 GLN D Protein S 1 FT #SUB 291 332 HIS B 2 2 SER D Protein S 1 FT #SUB 294 335 GLY B 2 2 SER D Protein B 2 FT #SUB 298 339 GLY B 1 1 HIS D Protein B 8 FT #SUB 300 341 GLU B 1 1 HIS D Protein S 5 FT #SUB 318 359 LEU B 1 1 HIS D Protein B 2 FT #SUB 319 360 VAL B 1 1 HIS D Protein A 7 FT #SUB 319 360 VAL B 3 3 GLN D Protein S 1 FT #SUB 320 361 GLY B 1 1 HIS D Protein B 5 FT #SUB 320 361 GLY B 2 2 SER D Protein B 3 FT #SUB 320 361 GLY B 3 3 GLN D Protein B 1 FT #SUB 321 362 GLY B 3 3 GLN D Protein B 1 FT #SUB 322 363 GLN B 3 3 GLN D Protein B 2 FT #SUB 322 363 GLN B 5 5 THR D Protein B 2 FT #SUB 323 364 LYS B 5 5 THR D Protein B 3 FT #SUB 324 365 GLU B 5 5 THR D Protein B 2 FT #SUB 568 609 TYR B 1 1 HIS D Protein S 3 FT #SUB 783 824 ARG B 26 26 LEU D Protein S 4 FT #SUB 783 824 ARG B 27 27 MET D Protein S 1 FT #SUB 790 831 TYR B 25 25 TRP D Protein S 4 FT #SUB 790 831 TYR B 26 26 LEU D Protein S 8 FT #SUB 790 831 TYR B 27 27 MET D Protein S 4 FT #SUB 790 831 TYR B 28 28 ASN D Protein S 2 FT #SUB 792 833 VAL B 28 28 ASN D Protein B 3 FT #SUB 793 834 PHE B 28 28 ASN D Protein S 1 FT #HET 157 198 ALA B 8 1104 J22 B A 5 FT #HET 160 201 LEU B 8 1104 J22 B A 21 FT #HET 161 202 PHE B 8 1104 J22 B A 10 FT #HET 163 204 LEU B 8 1104 J22 B A 12 FT #HET 164 205 GLU B 8 1104 J22 B A 21 FT #HET 167 208 THR B 8 1104 J22 B S 6 FT #HET 261 302 TYR B 8 1104 J22 B S 18 FT #HET 263 304 ILE B 8 1104 J22 B S 2 FT #HET 273 314 TYR B 8 1104 J22 B A 17 FT #HET 275 316 THR B 8 1104 J22 B S 7 FT #HET 319 360 VAL B 8 1104 J22 B A 11 FT #HET 320 361 GLY B 8 1104 J22 B B 9 FT #HET 321 362 GLY B 8 1104 J22 B B 4 FT #HET 322 363 GLN B 8 1104 J22 B B 3 FT #HET 323 364 LYS B 8 1104 J22 B A 20 FT #HET 333 374 ILE B 8 1104 J22 B A 11 FT #HET 335 376 ASN B 8 1104 J22 B S 7 FT #HET 436 477 ARG B 8 1104 J22 B A 11 FT #HET 438 479 ALA B 8 1104 J22 B S 7 FT #HET 488 529 GLU B 7 1103 DIO B A 15 FT #HET 489 530 PHE B 7 1103 DIO B S 9 FT #HET 497 538 LEU B 6 1102 PEG B S 10 FT #HET 533 574 LEU B 6 1102 PEG B S 1 FT #HET 566 607 TYR B 7 1103 DIO B S 4 FT #HET 594 635 ASN B 6 1102 PEG B A 19 FT #HET 597 638 GLN B 6 1102 PEG B S 5 FT #HET 598 639 PRO B 6 1102 PEG B S 2 FT #HET 599 640 ILE B 7 1103 DIO B S 7 FT #HET 691 732 ASN B 6 1102 PEG B B 7 FT #HET 692 733 ILE B 6 1102 PEG B A 14 FT #HET 693 734 THR B 6 1102 PEG B A 3 FT #HET 696 737 ALA B 6 1102 PEG B S 2 FT #HET 700 741 ILE B 6 1102 PEG B S 2 FT #HET 759 800 GLN B 5 1101 EPE B S 11 FT #HET 764 805 ASN B 5 1101 EPE B S 1 FT #HET 798 839 ARG B 5 1101 EPE B A 9 FT #HET 799 840 ALA B 5 1101 EPE B B 4 FT #HET 800 841 ASN B 5 1101 EPE B B 3 FT #HET 801 842 GLY B 5 1101 EPE B B 3 FT #HET 868 909 GLY B 5 1101 EPE B B 3 FT #HET 869 910 GLU B 5 1101 EPE B S 3 FT #HET 872 913 SER B 5 1101 EPE B S 9 FT #HET 874 915 GLN B 5 1101 EPE B S 6 FT #HET 879 920 ARG B 5 1101 EPE B S 14 FT DISORDER 1 1 FT DISORDER 927 936 FT DISORDER 971 978 CC SEQUENCE 959 AA (ATOM); CC NNPAIKRIGN HITKSPEDKR EYRGLELANG IKVLLISDPT TDKSSAALDV HIGSLSDPPN CC IAGLSHFLQH MLFLGTKKYP KENEYSQFLS EHAGSSNAFT SGEHTNYYFD VSHEHLEGAL CC DRFAQFFLSP LFDESAKDRE VNAVDSEHEK NVMNDAWRLF QLEKATGNPK HPFSKFGTGN CC KYTLETRPNQ EGIDVRQELL KFHSAYYSSN LMAVVVLGRE SLDDLTNLVV KLFSEVENKN CC VPLPEFPEHP FQEEHLKQLY KIVPIKDIRN LYVTFPIPDL QKYYKSNPGH YLGHLIGHEG CC PGSLLSELKS KGWVNTLVGG QKEGARGFMF FIINVDLTEE GLLHVEDIIL HMFQYIQKLR CC AEGPQEWVFQ ELKDLNAVAF RFKDKERPRG YTSKIAGILH YYPLEEVLTA EYLLEEFRPD CC LIEMVLDKLR PENVRVAIVS KSFEGKTDRT EEWYGTQYKQ EAIPDEVIKK WQNADLNGKF CC KLPTKNEFIP TNFEILPLEK EATPYPALIK DTAMSKLWFK QDDKFFLPKA NLNFEFFSPF CC AYVDPLHSNM AYLYLELLKD SLNEYAYAAE LAGLSYDLQN TIYGMYLSVK GYNDKQPILL CC KKIIEKMATF EIDEKRFEII KEAYMRSLNN FRAEQPHQHA MYYLRLLMTE VAWTKDELKE CC ALDDVTLPRL KAFIPQLLSR LHIEALLHGN ITKQAALGIM QMVEDTLIEH AHTKPLLPSQ CC LVRYREVQLP DRGWFVYQQR NEVHNNSGIE IYYQTDMQST SENMFLELFA QIISEPAFNT CC LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR VEAFLITMEK SIEDMTEEAF CC QKHIQALAIR RLDKPKKLSA ESAKYWGEII SQQYNFDRDN TEVAYLKTLT KEDIIKFYKE CC MLAVDAPRRH KVSVHVLARE MDSNPINLSQ APALPQPEVI QNMTEFKRGL PLFPLVKPH CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALD CC ATOM -NNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALD CC ************************************************* CC SEQRES VHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAF CC ATOM VHIGSLSDPPNIAGLSHFLQHMLFLGTKKYPKENEYSQFLSEHAGSSNAF CC ************************************************** CC SEQRES TSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHE CC ATOM TSGEHTNYYFDVSHEHLEGALDRFAQFFLSPLFDESAKDREVNAVDSEHE CC ************************************************** CC SEQRES KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQEL CC ATOM KNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQEL CC ************************************************** CC SEQRES LKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH CC ATOM LKFHSAYYSSNLMAVVVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEH CC ************************************************** CC SEQRES PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE CC ATOM PFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHE CC ************************************************** CC SEQRES GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII CC ATOM GPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDII CC ************************************************** CC SEQRES LHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGIL CC ATOM LHMFQYIQKLRAEGPQEWVFQELKDLNAVAFRFKDKERPRGYTSKIAGIL CC ************************************************** CC SEQRES HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR CC ATOM HYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDR CC ************************************************** CC SEQRES TEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLE CC ATOM TEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLE CC ************************************************** CC SEQRES KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSN CC ATOM KEATPYPALIKDTAMSKLWFKQDDKFFLPKANLNFEFFSPFAYVDPLHSN CC ************************************************** CC SEQRES MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL CC ATOM MAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPIL CC ************************************************** CC SEQRES LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMT CC ATOM LKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMT CC ************************************************** CC SEQRES EVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGI CC ATOM EVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGI CC ************************************************** CC SEQRES MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGI CC ATOM MQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNSGI CC ************************************************** CC SEQRES EIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRAN CC ATOM EIYYQTDMQSTSENMFLELFAQIISEPAFNTLRTKEQLGYIVFSGPRRAN CC ************************************************** CC SEQRES GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI CC ATOM GIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAI CC ************************************************** CC SEQRES RRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK CC ATOM RRLDKPKKLSAESAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYK CC ************************************************** CC SEQRES EMLAVDAPRRHKVSVHVLAREMDSNPVVGEFPAQNDINLSQAPALPQPEV CC ATOM EMLAVDAPRRHKVSVHVLAREMDSNP----------INLSQAPALPQPEV CC ************************** ************** CC SEQRES IQNMTEFKRGLPLFPLVKPHINFMAAKL CC ATOM IQNMTEFKRGLPLFPLVKPH-------- CC ******************** SQ SEQUENCE 978 AA; MW; CN; MNNPAIKRIG NHITKSPEDK REYRGLELAN GIKVLLISDP TTDKSSAALD VHIGSLSDPP NIAGLSHFLQ HMLFLGTKKY PKENEYSQFL SEHAGSSNAF TSGEHTNYYF DVSHEHLEGA LDRFAQFFLS PLFDESAKDR EVNAVDSEHE KNVMNDAWRL FQLEKATGNP KHPFSKFGTG NKYTLETRPN QEGIDVRQEL LKFHSAYYSS NLMAVVVLGR ESLDDLTNLV VKLFSEVENK NVPLPEFPEH PFQEEHLKQL YKIVPIKDIR NLYVTFPIPD LQKYYKSNPG HYLGHLIGHE GPGSLLSELK SKGWVNTLVG GQKEGARGFM FFIINVDLTE EGLLHVEDII LHMFQYIQKL RAEGPQEWVF QELKDLNAVA FRFKDKERPR GYTSKIAGIL HYYPLEEVLT AEYLLEEFRP DLIEMVLDKL RPENVRVAIV SKSFEGKTDR TEEWYGTQYK QEAIPDEVIK KWQNADLNGK FKLPTKNEFI PTNFEILPLE KEATPYPALI KDTAMSKLWF KQDDKFFLPK ANLNFEFFSP FAYVDPLHSN MAYLYLELLK DSLNEYAYAA ELAGLSYDLQ NTIYGMYLSV KGYNDKQPIL LKKIIEKMAT FEIDEKRFEI IKEAYMRSLN NFRAEQPHQH AMYYLRLLMT EVAWTKDELK EALDDVTLPR LKAFIPQLLS RLHIEALLHG NITKQAALGI MQMVEDTLIE HAHTKPLLPS QLVRYREVQL PDRGWFVYQQ RNEVHNNSGI EIYYQTDMQS TSENMFLELF AQIISEPAFN TLRTKEQLGY IVFSGPRRAN GIQGLRFIIQ SEKPPHYLES RVEAFLITME KSIEDMTEEA FQKHIQALAI RRLDKPKKLS AESAKYWGEI ISQQYNFDRD NTEVAYLKTL TKEDIIKFYK EMLAVDAPRR HKVSVHVLAR EMDSNPVVGE FPAQNDINLS QAPALPQPEV IQNMTEFKRG LPLFPLVKPH INFMAAKL // ID 6EDSC STANDARD; PRT; 29 AA. DT CONVERTED FROM PDB (SEQRES) 6EDS DE Glucagon OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.180 CC R-Factor 0.179 FT #SUB 1 1 HIS C 298 339 GLY A Protein B 6 FT #SUB 1 1 HIS C 300 341 GLU A Protein A 5 FT #SUB 1 1 HIS C 318 359 LEU A Protein S 1 FT #SUB 1 1 HIS C 319 360 VAL A Protein A 7 FT #SUB 1 1 HIS C 320 361 GLY A Protein B 2 FT #SUB 1 1 HIS C 568 609 TYR A Protein B 4 FT #SUB 2 2 SER C 291 332 HIS A Protein S 1 FT #SUB 2 2 SER C 294 335 GLY A Protein S 3 FT #SUB 2 2 SER C 320 361 GLY A Protein A 4 FT #SUB 3 3 GLN C 319 360 VAL A Protein S 1 FT #SUB 3 3 GLN C 320 361 GLY A Protein B 1 FT #SUB 3 3 GLN C 321 362 GLY A Protein B 1 FT #SUB 3 3 GLN C 322 363 GLN A Protein B 2 FT #SUB 4 4 GLY C 322 363 GLN A Protein B 2 FT #SUB 5 5 THR C 322 363 GLN A Protein A 3 FT #SUB 5 5 THR C 323 364 LYS A Protein S 2 FT #SUB 5 5 THR C 324 365 GLU A Protein A 9 FT #SUB 22 22 PHE C 157 198 ALA A Protein S 1 FT #SUB 22 22 PHE C 158 199 TRP A Protein S 7 FT #SUB 22 22 PHE C 161 202 PHE A Protein S 2 FT #SUB 23 23 VAL C 100 141 PHE A Protein S 2 FT #SUB 23 23 VAL C 101 142 THR A Protein B 1 FT #SUB 23 23 VAL C 102 143 SER A Protein S 1 FT #SUB 24 24 GLN C 55 96 SER A Protein S 1 FT #SUB 24 24 GLN C 67 108 HIS A Protein A 3 FT #SUB 24 24 GLN C 70 111 GLN A Protein B 1 FT #SUB 24 24 GLN C 100 141 PHE A Protein B 3 FT #SUB 24 24 GLN C 101 142 THR A Protein A 6 FT #SUB 24 24 GLN C 148 189 GLU A Protein B 1 FT #SUB 24 24 GLN C 158 199 TRP A Protein S 1 FT #SUB 25 25 TRP C 67 108 HIS A Protein B 1 FT #SUB 25 25 TRP C 70 111 GLN A Protein B 1 FT #SUB 25 25 TRP C 71 112 HIS A Protein B 1 FT #SUB 25 25 TRP C 98 139 ASN A Protein S 1 FT #SUB 25 25 TRP C 99 140 ALA A Protein A 3 FT #SUB 25 25 TRP C 100 141 PHE A Protein S 2 FT #SUB 25 25 TRP C 109 150 TYR A Protein S 2 FT #SUB 25 25 TRP C 148 189 GLU A Protein B 6 FT #SUB 25 25 TRP C 790 831 TYR A Protein A 4 FT #SUB 26 26 LEU C 70 111 GLN A Protein A 3 FT #SUB 26 26 LEU C 71 112 HIS A Protein A 6 FT #SUB 26 26 LEU C 74 115 PHE A Protein S 4 FT #SUB 26 26 LEU C 98 139 ASN A Protein A 3 FT #SUB 26 26 LEU C 99 140 ALA A Protein A 4 FT #SUB 26 26 LEU C 783 824 ARG A Protein B 3 FT #SUB 26 26 LEU C 790 831 TYR A Protein B 5 FT #SUB 27 27 MET C 97 138 SER A Protein S 1 FT #SUB 27 27 MET C 98 139 ASN A Protein A 9 FT #SUB 27 27 MET C 779 820 PHE A Protein S 2 FT #SUB 27 27 MET C 783 824 ARG A Protein B 1 FT #SUB 27 27 MET C 790 831 TYR A Protein B 5 FT #SUB 28 28 ASN C 779 820 PHE A Protein S 2 FT #SUB 28 28 ASN C 790 831 TYR A Protein A 3 FT #SUB 28 28 ASN C 791 832 ILE A Protein S 1 FT #SUB 28 28 ASN C 792 833 VAL A Protein S 2 FT #HET 3 3 GLN C 1 1101 J22 A A 9 FT #HET 5 5 THR C 1 1101 J22 A S 5 FT #HET 22 22 PHE C 1 1101 J22 A S 12 FT DISORDER 6 21 FT DISORDER 29 29 CC Miss-BB 1 CC Miss-SC 1 CC SEQUENCE 12 AA (ATOM); CC HSQGTFVQWL MN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HSQGTFTSDYSKYLDSRRAQDFVQWLMNT CC ATOM HSQGT----------------FVQWLMN- CC ***** ******* SQ SEQUENCE 29 AA; MW; CN; HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT // ID 6EDSD STANDARD; PRT; 29 AA. DT CONVERTED FROM PDB (SEQRES) 6EDS DE Glucagon OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.180 CC R-Factor 0.179 FT #SUB 1 1 HIS D 298 339 GLY B Protein B 8 FT #SUB 1 1 HIS D 300 341 GLU B Protein A 5 FT #SUB 1 1 HIS D 318 359 LEU B Protein B 2 FT #SUB 1 1 HIS D 319 360 VAL B Protein A 7 FT #SUB 1 1 HIS D 320 361 GLY B Protein B 5 FT #SUB 1 1 HIS D 568 609 TYR B Protein A 3 FT #SUB 2 2 SER D 291 332 HIS B Protein S 1 FT #SUB 2 2 SER D 294 335 GLY B Protein S 2 FT #SUB 2 2 SER D 320 361 GLY B Protein B 3 FT #SUB 3 3 GLN D 319 360 VAL B Protein S 1 FT #SUB 3 3 GLN D 320 361 GLY B Protein B 1 FT #SUB 3 3 GLN D 321 362 GLY B Protein B 1 FT #SUB 3 3 GLN D 322 363 GLN B Protein B 2 FT #SUB 5 5 THR D 322 363 GLN B Protein S 2 FT #SUB 5 5 THR D 323 364 LYS B Protein S 3 FT #SUB 5 5 THR D 324 365 GLU B Protein S 2 FT #SUB 22 22 PHE D 101 142 THR B Protein B 1 FT #SUB 22 22 PHE D 158 199 TRP B Protein S 6 FT #SUB 23 23 VAL D 100 141 PHE B Protein S 1 FT #SUB 23 23 VAL D 101 142 THR B Protein B 1 FT #SUB 24 24 GLN D 67 108 HIS B Protein A 3 FT #SUB 24 24 GLN D 70 111 GLN B Protein B 1 FT #SUB 24 24 GLN D 99 140 ALA B Protein B 1 FT #SUB 24 24 GLN D 100 141 PHE B Protein B 3 FT #SUB 24 24 GLN D 101 142 THR B Protein A 8 FT #SUB 24 24 GLN D 148 189 GLU B Protein A 3 FT #SUB 24 24 GLN D 158 199 TRP B Protein S 1 FT #SUB 25 25 TRP D 98 139 ASN B Protein S 2 FT #SUB 25 25 TRP D 99 140 ALA B Protein A 3 FT #SUB 25 25 TRP D 100 141 PHE B Protein S 3 FT #SUB 25 25 TRP D 109 150 TYR B Protein S 2 FT #SUB 25 25 TRP D 148 189 GLU B Protein B 4 FT #SUB 25 25 TRP D 790 831 TYR B Protein B 4 FT #SUB 26 26 LEU D 70 111 GLN B Protein A 3 FT #SUB 26 26 LEU D 71 112 HIS B Protein A 6 FT #SUB 26 26 LEU D 74 115 PHE B Protein S 6 FT #SUB 26 26 LEU D 98 139 ASN B Protein A 2 FT #SUB 26 26 LEU D 99 140 ALA B Protein A 2 FT #SUB 26 26 LEU D 783 824 ARG B Protein A 4 FT #SUB 26 26 LEU D 790 831 TYR B Protein B 8 FT #SUB 27 27 MET D 97 138 SER B Protein S 1 FT #SUB 27 27 MET D 98 139 ASN B Protein A 8 FT #SUB 27 27 MET D 783 824 ARG B Protein B 1 FT #SUB 27 27 MET D 790 831 TYR B Protein B 4 FT #SUB 28 28 ASN D 790 831 TYR B Protein B 2 FT #SUB 28 28 ASN D 792 833 VAL B Protein S 3 FT #SUB 28 28 ASN D 793 834 PHE B Protein S 1 FT #HET 3 3 GLN D 8 1104 J22 B A 16 FT #HET 5 5 THR D 8 1104 J22 B S 7 FT #HET 22 22 PHE D 8 1104 J22 B S 14 FT DISORDER 6 21 FT DISORDER 29 29 CC Miss-BB 1 CC Miss-SC 1 CC SEQUENCE 12 AA (ATOM); CC HSQGTFVQWL MN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES HSQGTFTSDYSKYLDSRRAQDFVQWLMNT CC ATOM HSQGT----------------FVQWLMN- CC ***** ******* SQ SEQUENCE 29 AA; MW; CN; HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT //