ID 6E9WA STANDARD; PRT; 443 AA. DT CONVERTED FROM PDB (SEQRES) 6E9W DE Rho-associated protein kinase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.960 CC R-Factor 0.197 FT #SUB 196 168 TYR A 196 168 TYR B Protein S 5 FT #SUB 196 168 TYR A 202 174 TRP B Protein S 4 FT #SUB 199 171 PRO A 199 171 PRO B Protein S 1 FT #SUB 201 173 LYS A 197 169 ASP B Protein S 13 FT #SUB 201 173 LYS A 198 170 VAL B Protein S 3 FT #SUB 201 173 LYS A 199 171 PRO B Protein S 1 FT #SUB 201 173 LYS A 332 304 ASP B Protein S 3 FT #SUB 202 174 TRP A 197 169 ASP B Protein S 7 FT #SUB 204 176 ARG A 332 304 ASP B Protein S 5 FT #SUB 367 339 LYS A 330 302 ASP B Protein B 2 FT #SUB 368 340 ASN A 330 302 ASP B Protein B 5 FT #SUB 369 341 ASP A 328 300 PRO B Protein S 3 FT #SUB 369 341 ASP A 330 302 ASP B Protein A 5 FT #SUB 369 341 ASP A 332 304 ASP B Protein S 1 FT #SUB 382 354 PRO A 196 168 TYR B Protein B 4 FT #SUB 382 354 PRO A 197 169 ASP B Protein B 3 FT #SUB 383 355 VAL A 195 167 ASN B Protein B 1 FT #SUB 384 356 VAL A 195 167 ASN B Protein B 8 FT #SUB 386 358 ASP A 195 167 ASN B Protein S 4 FT #SUB 386 358 ASP A 394 366 SER B Protein S 1 FT #HET 110 82 ILE A 1 501 J0P A S 2 FT #HET 113 85 GLY A 1 501 J0P A B 10 FT #HET 114 86 ALA A 1 501 J0P A A 5 FT #HET 115 87 PHE A 1 501 J0P A A 5 FT #HET 116 88 GLY A 1 501 J0P A B 6 FT #HET 117 89 GLU A 1 501 J0P A B 2 FT #HET 118 90 VAL A 1 501 J0P A S 4 FT #HET 131 103 ALA A 1 501 J0P A S 3 FT #HET 133 105 LYS A 1 501 J0P A S 10 FT #HET 135 107 LEU A 1 501 J0P A S 3 FT #HET 169 141 TYR A 2 502 SO4 A S 5 FT #HET 181 153 MET A 1 501 J0P A S 1 FT #HET 182 154 GLU A 1 501 J0P A B 2 FT #HET 183 155 TYR A 1 501 J0P A A 4 FT #HET 184 156 MET A 1 501 J0P A A 8 FT #HET 233 205 LEU A 1 501 J0P A S 1 FT #HET 243 215 ALA A 1 501 J0P A B 2 FT #HET 244 216 ASP A 1 501 J0P A A 7 FT #HET 396 368 PHE A 1 501 J0P A S 1 FT #HET 431 403 ARG A 2 502 SO4 A S 8 FT DISORDER 1 36 FT DISORDER 277 281 FT DISORDER 400 407 FT DISORDER 433 443 CC SEQUENCE 383 AA (ATOM); CC TRFEKMDNLL RDPKSEVNSD CLLDGLDALV YDLDFPALRK NKNIDNFLSR YKDTINKIRD CC LRMKAEDYEV VKVIGRGAFG EVQLVRHKST RKVYAMKLLS KFEMIKRSDS AFFWEERDIM CC AFANSPWVVQ LFYAFQDDRY LYMVMEYMPG GDLVNLMSNY DVPEKWARFY TAEVVLALDA CC IHSMGFIHRD VKPDNMLLDK SGHLKLADFG TCMKMNKEGM VRCDTAVGTP DYISPEVLKS CC YYGRECDWWS VGVFLYEMLV GDTPFYADSL VGTYSKIMNH KNSLTFPDDN DISKEAKNLI CC CAFLTDREVR LGRNGVEEIK RHLFFKNDQW AWETLRDTVA PVVPDLSSDI DTSNFDDLTF CC PIPKAFVGNQ LPFVGFTYYS NRR CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSYYHHHHHHDYDIPTTENLYFQGAMDPLVPRGSFETRFEKMDNLLRDPK CC ATOM ------------------------------------TRFEKMDNLLRDPK CC ************** CC SEQRES SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMK CC ATOM SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMK CC ************************************************** CC SEQRES AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW CC ATOM AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW CC ************************************************** CC SEQRES EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE CC ATOM EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE CC ************************************************** CC SEQRES KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK CC ATOM KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK CC ************************************************** CC SEQRES MNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEML CC ATOM MNKEGMVRCDTAVGTPDYISPEVLKS-----YYGRECDWWSVGVFLYEML CC ************************** ******************* CC SEQRES VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREV CC ATOM VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREV CC ************************************************** CC SEQRES RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLE CC ATOM RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDL- CC ************************************************* CC SEQRES EDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNR CC ATOM -------TFPIPKAFVGNQLPFVGFTYYSNRR----------- CC ************************* SQ SEQUENCE 443 AA; MW; CN; MSYYHHHHHH DYDIPTTENL YFQGAMDPLV PRGSFETRFE KMDNLLRDPK SEVNSDCLLD GLDALVYDLD FPALRKNKNI DNFLSRYKDT INKIRDLRMK AEDYEVVKVI GRGAFGEVQL VRHKSTRKVY AMKLLSKFEM IKRSDSAFFW EERDIMAFAN SPWVVQLFYA FQDDRYLYMV MEYMPGGDLV NLMSNYDVPE KWARFYTAEV VLALDAIHSM GFIHRDVKPD NMLLDKSGHL KLADFGTCMK MNKEGMVRCD TAVGTPDYIS PEVLKSQGGD GYYGRECDWW SVGVFLYEML VGDTPFYADS LVGTYSKIMN HKNSLTFPDD NDISKEAKNL ICAFLTDREV RLGRNGVEEI KRHLFFKNDQ WAWETLRDTV APVVPDLSSD IDTSNFDDLE EDKGEEETFP IPKAFVGNQL PFVGFTYYSN RRYLSSANPN DNR // ID 6E9WB STANDARD; PRT; 443 AA. DT CONVERTED FROM PDB (SEQRES) 6E9W DE Rho-associated protein kinase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.960 CC R-Factor 0.197 FT #SUB 195 167 ASN B 383 355 VAL A Protein B 1 FT #SUB 195 167 ASN B 384 356 VAL A Protein A 8 FT #SUB 195 167 ASN B 386 358 ASP A Protein S 4 FT #SUB 196 168 TYR B 196 168 TYR A Protein S 5 FT #SUB 196 168 TYR B 382 354 PRO A Protein A 4 FT #SUB 197 169 ASP B 201 173 LYS A Protein A 13 FT #SUB 197 169 ASP B 202 174 TRP A Protein A 7 FT #SUB 197 169 ASP B 382 354 PRO A Protein A 3 FT #SUB 198 170 VAL B 201 173 LYS A Protein B 3 FT #SUB 199 171 PRO B 199 171 PRO A Protein S 1 FT #SUB 199 171 PRO B 201 173 LYS A Protein B 1 FT #SUB 202 174 TRP B 196 168 TYR A Protein S 4 FT #SUB 328 300 PRO B 369 341 ASP A Protein S 3 FT #SUB 330 302 ASP B 367 339 LYS A Protein S 2 FT #SUB 330 302 ASP B 368 340 ASN A Protein A 5 FT #SUB 330 302 ASP B 369 341 ASP A Protein B 5 FT #SUB 332 304 ASP B 201 173 LYS A Protein S 3 FT #SUB 332 304 ASP B 204 176 ARG A Protein S 5 FT #SUB 332 304 ASP B 369 341 ASP A Protein S 1 FT #SUB 394 366 SER B 386 358 ASP A Protein B 1 FT #HET 110 82 ILE B 3 501 J0P B S 2 FT #HET 113 85 GLY B 3 501 J0P B B 10 FT #HET 114 86 ALA B 3 501 J0P B B 4 FT #HET 115 87 PHE B 3 501 J0P B A 8 FT #HET 116 88 GLY B 3 501 J0P B B 7 FT #HET 117 89 GLU B 3 501 J0P B B 4 FT #HET 118 90 VAL B 3 501 J0P B S 8 FT #HET 131 103 ALA B 3 501 J0P B S 3 FT #HET 133 105 LYS B 3 501 J0P B S 6 FT #HET 134 106 LEU B 3 501 J0P B B 1 FT #HET 135 107 LEU B 3 501 J0P B S 4 FT #HET 152 124 GLU B 3 501 J0P B S 1 FT #HET 181 153 MET B 3 501 J0P B S 1 FT #HET 182 154 GLU B 3 501 J0P B B 2 FT #HET 183 155 TYR B 3 501 J0P B A 4 FT #HET 184 156 MET B 3 501 J0P B A 9 FT #HET 233 205 LEU B 3 501 J0P B S 2 FT #HET 243 215 ALA B 3 501 J0P B B 1 FT #HET 244 216 ASP B 3 501 J0P B A 12 FT #HET 396 368 PHE B 3 501 J0P B S 1 FT DISORDER 1 34 FT DISORDER 141 146 FT DISORDER 278 280 FT DISORDER 401 406 FT DISORDER 430 443 CC SEQUENCE 380 AA (ATOM); CC FETRFEKMDN LLRDPKSEVN SDCLLDGLDA LVYDLDFPAL RKNKNIDNFL SRYKDTINKI CC RDLRMKAEDY EVVKVIGRGA FGEVQLVRHK STRKVYAMKL LSKFEMAFFW EERDIMAFAN CC SPWVVQLFYA FQDDRYLYMV MEYMPGGDLV NLMSNYDVPE KWARFYTAEV VLALDAIHSM CC GFIHRDVKPD NMLLDKSGHL KLADFGTCMK MNKEGMVRCD TAVGTPDYIS PEVLKSQGYY CC GRECDWWSVG VFLYEMLVGD TPFYADSLVG TYSKIMNHKN SLTFPDDNDI SKEAKNLICA CC FLTDREVRLG RNGVEEIKRH LFFKNDQWAW ETLRDTVAPV VPDLSSDIDT SNFDDLEETF CC PIPKAFVGNQ LPFVGFTYYS CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MSYYHHHHHHDYDIPTTENLYFQGAMDPLVPRGSFETRFEKMDNLLRDPK CC ATOM ----------------------------------FETRFEKMDNLLRDPK CC **************** CC SEQRES SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMK CC ATOM SEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMK CC ************************************************** CC SEQRES AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFW CC ATOM AEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEM------AFFW CC **************************************** **** CC SEQRES EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE CC ATOM EERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPE CC ************************************************** CC SEQRES KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK CC ATOM KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMK CC ************************************************** CC SEQRES MNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEML CC ATOM MNKEGMVRCDTAVGTPDYISPEVLKSQ---GYYGRECDWWSVGVFLYEML CC *************************** ******************** CC SEQRES VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREV CC ATOM VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREV CC ************************************************** CC SEQRES RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLE CC ATOM RLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLE CC ************************************************** CC SEQRES EDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNR CC ATOM ------ETFPIPKAFVGNQLPFVGFTYYS-------------- CC *********************** SQ SEQUENCE 443 AA; MW; CN; MSYYHHHHHH DYDIPTTENL YFQGAMDPLV PRGSFETRFE KMDNLLRDPK SEVNSDCLLD GLDALVYDLD FPALRKNKNI DNFLSRYKDT INKIRDLRMK AEDYEVVKVI GRGAFGEVQL VRHKSTRKVY AMKLLSKFEM IKRSDSAFFW EERDIMAFAN SPWVVQLFYA FQDDRYLYMV MEYMPGGDLV NLMSNYDVPE KWARFYTAEV VLALDAIHSM GFIHRDVKPD NMLLDKSGHL KLADFGTCMK MNKEGMVRCD TAVGTPDYIS PEVLKSQGGD GYYGRECDWW SVGVFLYEML VGDTPFYADS LVGTYSKIMN HKNSLTFPDD NDISKEAKNL ICAFLTDREV RLGRNGVEEI KRHLFFKNDQ WAWETLRDTV APVVPDLSSD IDTSNFDDLE EDKGEEETFP IPKAFVGNQL PFVGFTYYSN RRYLSSANPN DNR //