ID	6CYDA	STANDARD;	PRT;	373	AA.
DT	CONVERTED FROM PDB (SEQRES) 6CYD
DE	cGMP-dependent 3',5'-cyclic phosphodiesterase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.690
CC	R-Factor	0.184
FT	#SUB	171	 717 	ALA	A	248	 794 	GLN	B	Protein	S	1
FT	#SUB	172	 718 	LEU	A	251	 797 	ARG	B	Protein	A	5
FT	#SUB	175	 721 	SER	A	226	 772 	HIS	B	Protein	A	3
FT	#SUB	175	 721 	SER	A	229	 775 	ARG	B	Protein	B	4
FT	#SUB	175	 721 	SER	A	230	 776 	ILE	B	Protein	S	1
FT	#SUB	176	 722 	GLU	A	220	 766 	LEU	B	Protein	S	1
FT	#SUB	176	 722 	GLU	A	226	 772 	HIS	B	Protein	S	6
FT	#SUB	182	 728 	ARG	A	182	 728 	ARG	B	Protein	S	1
FT	#SUB	189	 735 	ILE	A	209	 755 	GLN	B	Protein	S	3
FT	#SUB	193	 739 	ASN	A	205	 751 	ARG	B	Protein	S	2
FT	#SUB	193	 739 	ASN	A	206	 752 	LYS	B	Protein	A	2
FT	#SUB	198	 744 	ASN	A	205	 751 	ARG	B	Protein	S	2
FT	#SUB	201	 747 	ASP	A	205	 751 	ARG	B	Protein	A	6
FT	#SUB	205	 751 	ARG	A	193	 739 	ASN	B	Protein	A	3
FT	#SUB	206	 752 	LYS	A	193	 739 	ASN	B	Protein	B	2
FT	#SUB	208	 754 	TYR	A	205	 751 	ARG	B	Protein	S	7
FT	#SUB	209	 755 	GLN	A	189	 735 	ILE	B	Protein	S	4
FT	#SUB	209	 755 	GLN	A	193	 739 	ASN	B	Protein	S	1
FT	#SUB	209	 755 	GLN	A	212	 758 	LEU	B	Protein	S	1
FT	#SUB	212	 758 	LEU	A	209	 755 	GLN	B	Protein	S	1
FT	#SUB	216	 762 	ARG	A	213	 759 	ASP	B	Protein	S	1
FT	#SUB	216	 762 	ARG	A	216	 762 	ARG	B	Protein	S	14
FT	#SUB	220	 766 	LEU	A	176	 722 	GLU	B	Protein	S	4
FT	#SUB	226	 772 	HIS	A	175	 721 	SER	B	Protein	S	1
FT	#SUB	226	 772 	HIS	A	176	 722 	GLU	B	Protein	S	4
FT	#SUB	229	 775 	ARG	A	175	 721 	SER	B	Protein	S	5
FT	#SUB	229	 775 	ARG	A	176	 722 	GLU	B	Protein	S	1
FT	#SUB	230	 776 	ILE	A	175	 721 	SER	B	Protein	S	1
FT	#SUB	251	 797 	ARG	A	172	 718 	LEU	B	Protein	S	3
FT	#HET	109	 655 	TYR	A	3	1003 	FKG	A	S	2
FT	#HET	110	 656 	HIS	A	3	1003 	FKG	A	S	2
FT	#HET	114	 660 	HIS	A	1	1001 	ZN	A	S	3
FT	#HET	150	 696 	HIS	A	1	1001 	ZN	A	S	3
FT	#HET	151	 697 	ASP	A	1	1001 	ZN	A	S	3
FT	#HET	151	 697 	ASP	A	2	1002 	MG	A	S	3
FT	#HET	222	 768 	THR	A	3	1003 	FKG	A	B	6
FT	#HET	222	 768 	THR	A	5	1005 	EDO	A	B	2
FT	#HET	223	 769 	ASP	A	3	1003 	FKG	A	B	2
FT	#HET	223	 769 	ASP	A	5	1005 	EDO	A	A	3
FT	#HET	224	 770 	LEU	A	3	1003 	FKG	A	A	3
FT	#HET	224	 770 	LEU	A	5	1005 	EDO	A	A	5
FT	#HET	228	 774 	LEU	A	4	1004 	EDO	A	S	1
FT	#HET	259	 805 	THR	A	3	1003 	FKG	A	A	5
FT	#HET	262	 808 	ASP	A	1	1001 	ZN	A	S	3
FT	#HET	262	 808 	ASP	A	3	1003 	FKG	A	S	5
FT	#HET	263	 809 	LEU	A	3	1003 	FKG	A	A	10
FT	#HET	266	 812 	GLN	A	3	1003 	FKG	A	S	5
FT	#HET	276	 822 	ILE	A	3	1003 	FKG	A	S	1
FT	#HET	280	 826 	ILE	A	3	1003 	FKG	A	S	6
FT	#HET	281	 827 	TYR	A	3	1003 	FKG	A	S	1
FT	#HET	284	 830 	PHE	A	3	1003 	FKG	A	S	1
FT	#HET	301	 847 	MET	A	3	1003 	FKG	A	S	1
FT	#HET	313	 859 	GLN	A	3	1003 	FKG	A	S	10
FT	#HET	316	 862 	PHE	A	3	1003 	FKG	A	S	22
FT	#HET	319	 865 	HIS	A	4	1004 	EDO	A	S	4
FT	#HET	320	 866 	ILE	A	4	1004 	EDO	A	S	1
FT	DISORDER	1	18
FT	DISORDER	27	35
FT	DISORDER	371	373
CC	SEQUENCE	343 AA (ATOM);
CC	SLYKKAGFYT KLLHDGIQPV AAIDSNFASF TYTPRSLPED DTSMAILSML QDMNFINNYK
CC	IDCPTLARFC LMVKKGYRDP PYHNWMHAFS VSHFCYLLYK NLELTNYLED IEIFALFISC
CC	MCHDLDHRGT NNSFQVASKS VLAALYSSEG SVMERHHFAQ AIAILNTHGC NIFDHFSRKD
CC	YQRMLDLMRD IILATDLAHH LRIFKDLQKM AEVGYDRNNK QHHRLLLCLL MTSCDLSDQT
CC	KGWKTTRKIA ELIYKEFFSQ GDLEKAMGNR PMEMMDREKA YIPELQISFM EHIAMPIYKL
CC	LQDLFPKAAE LYERVASNRE HWTKVSHKFT IRGLPSNNSL DFL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MHHHHHHENLYFQGELSTSLYKKAGFDDDDKSDDEYTKLLHDGIQPVAAI
CC	ATOM   ------------------SLYKKAGF---------YTKLLHDGIQPVAAI
CC	                         ********         ***************
CC	SEQRES DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV
CC	ATOM   DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV
CC	       **************************************************
CC	SEQRES KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH
CC	ATOM   KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH
CC	       **************************************************
CC	SEQRES DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF
CC	ATOM   DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF
CC	       **************************************************
CC	SEQRES DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH
CC	ATOM   DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH
CC	       **************************************************
CC	SEQRES RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
CC	ATOM   RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
CC	       **************************************************
CC	SEQRES MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT
CC	ATOM   MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT
CC	       **************************************************
CC	SEQRES KVSHKFTIRGLPSNNSLDFLDEE
CC	ATOM   KVSHKFTIRGLPSNNSLDFL---
CC	       ********************   
SQ	SEQUENCE	373 AA;      MW;         CN;
	MHHHHHHENL YFQGELSTSL YKKAGFDDDD KSDDEYTKLL HDGIQPVAAI DSNFASFTYT
	PRSLPEDDTS MAILSMLQDM NFINNYKIDC PTLARFCLMV KKGYRDPPYH NWMHAFSVSH
	FCYLLYKNLE LTNYLEDIEI FALFISCMCH DLDHRGTNNS FQVASKSVLA ALYSSEGSVM
	ERHHFAQAIA ILNTHGCNIF DHFSRKDYQR MLDLMRDIIL ATDLAHHLRI FKDLQKMAEV
	GYDRNNKQHH RLLLCLLMTS CDLSDQTKGW KTTRKIAELI YKEFFSQGDL EKAMGNRPME
	MMDREKAYIP ELQISFMEHI AMPIYKLLQD LFPKAAELYE RVASNREHWT KVSHKFTIRG
	LPSNNSLDFL DEE
//
ID	6CYDB	STANDARD;	PRT;	373	AA.
DT	CONVERTED FROM PDB (SEQRES) 6CYD
DE	cGMP-dependent 3',5'-cyclic phosphodiesterase
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.690
CC	R-Factor	0.184
FT	#SUB	172	 718 	LEU	B	251	 797 	ARG	A	Protein	S	3
FT	#SUB	175	 721 	SER	B	226	 772 	HIS	A	Protein	B	1
FT	#SUB	175	 721 	SER	B	229	 775 	ARG	A	Protein	B	5
FT	#SUB	175	 721 	SER	B	230	 776 	ILE	A	Protein	S	1
FT	#SUB	176	 722 	GLU	B	220	 766 	LEU	A	Protein	S	4
FT	#SUB	176	 722 	GLU	B	226	 772 	HIS	A	Protein	S	4
FT	#SUB	176	 722 	GLU	B	229	 775 	ARG	A	Protein	S	1
FT	#SUB	182	 728 	ARG	B	182	 728 	ARG	A	Protein	S	1
FT	#SUB	189	 735 	ILE	B	209	 755 	GLN	A	Protein	S	4
FT	#SUB	193	 739 	ASN	B	205	 751 	ARG	A	Protein	S	3
FT	#SUB	193	 739 	ASN	B	206	 752 	LYS	A	Protein	S	2
FT	#SUB	193	 739 	ASN	B	209	 755 	GLN	A	Protein	S	1
FT	#SUB	205	 751 	ARG	B	193	 739 	ASN	A	Protein	A	2
FT	#SUB	205	 751 	ARG	B	198	 744 	ASN	A	Protein	S	2
FT	#SUB	205	 751 	ARG	B	201	 747 	ASP	A	Protein	S	6
FT	#SUB	205	 751 	ARG	B	208	 754 	TYR	A	Protein	S	7
FT	#SUB	206	 752 	LYS	B	193	 739 	ASN	A	Protein	S	2
FT	#SUB	209	 755 	GLN	B	189	 735 	ILE	A	Protein	S	3
FT	#SUB	209	 755 	GLN	B	212	 758 	LEU	A	Protein	S	1
FT	#SUB	212	 758 	LEU	B	209	 755 	GLN	A	Protein	S	1
FT	#SUB	213	 759 	ASP	B	216	 762 	ARG	A	Protein	S	1
FT	#SUB	216	 762 	ARG	B	216	 762 	ARG	A	Protein	S	14
FT	#SUB	220	 766 	LEU	B	176	 722 	GLU	A	Protein	S	1
FT	#SUB	226	 772 	HIS	B	175	 721 	SER	A	Protein	S	3
FT	#SUB	226	 772 	HIS	B	176	 722 	GLU	A	Protein	S	6
FT	#SUB	229	 775 	ARG	B	175	 721 	SER	A	Protein	S	4
FT	#SUB	230	 776 	ILE	B	175	 721 	SER	A	Protein	S	1
FT	#SUB	248	 794 	GLN	B	171	 717 	ALA	A	Protein	S	1
FT	#SUB	251	 797 	ARG	B	172	 718 	LEU	A	Protein	S	5
FT	#HET	109	 655 	TYR	B	8	1003 	FKG	B	S	2
FT	#HET	110	 656 	HIS	B	8	1003 	FKG	B	S	2
FT	#HET	114	 660 	HIS	B	6	1001 	ZN	B	S	3
FT	#HET	150	 696 	HIS	B	6	1001 	ZN	B	S	3
FT	#HET	151	 697 	ASP	B	6	1001 	ZN	B	S	3
FT	#HET	151	 697 	ASP	B	7	1002 	MG	B	S	3
FT	#HET	222	 768 	THR	B	8	1003 	FKG	B	B	3
FT	#HET	222	 768 	THR	B	9	1004 	EDO	B	B	2
FT	#HET	223	 769 	ASP	B	8	1003 	FKG	B	B	1
FT	#HET	223	 769 	ASP	B	9	1004 	EDO	B	A	3
FT	#HET	224	 770 	LEU	B	8	1003 	FKG	B	A	4
FT	#HET	224	 770 	LEU	B	9	1004 	EDO	B	A	5
FT	#HET	259	 805 	THR	B	8	1003 	FKG	B	A	3
FT	#HET	262	 808 	ASP	B	6	1001 	ZN	B	S	3
FT	#HET	262	 808 	ASP	B	8	1003 	FKG	B	S	4
FT	#HET	263	 809 	LEU	B	8	1003 	FKG	B	A	11
FT	#HET	266	 812 	GLN	B	8	1003 	FKG	B	S	5
FT	#HET	276	 822 	ILE	B	8	1003 	FKG	B	S	1
FT	#HET	280	 826 	ILE	B	8	1003 	FKG	B	S	7
FT	#HET	281	 827 	TYR	B	8	1003 	FKG	B	S	1
FT	#HET	313	 859 	GLN	B	8	1003 	FKG	B	S	10
FT	#HET	316	 862 	PHE	B	8	1003 	FKG	B	S	26
FT	#HET	324	 870 	ILE	B	8	1003 	FKG	B	S	1
FT	DISORDER	1	15
FT	DISORDER	28	34
FT	DISORDER	371	373
CC	SEQUENCE	348 AA (ATOM);
CC	LSTSLYKKAG FDEYTKLLHD GIQPVAAIDS NFASFTYTPR SLPEDDTSMA ILSMLQDMNF
CC	INNYKIDCPT LARFCLMVKK GYRDPPYHNW MHAFSVSHFC YLLYKNLELT NYLEDIEIFA
CC	LFISCMCHDL DHRGTNNSFQ VASKSVLAAL YSSEGSVMER HHFAQAIAIL NTHGCNIFDH
CC	FSRKDYQRML DLMRDIILAT DLAHHLRIFK DLQKMAEVGY DRNNKQHHRL LLCLLMTSCD
CC	LSDQTKGWKT TRKIAELIYK EFFSQGDLEK AMGNRPMEMM DREKAYIPEL QISFMEHIAM
CC	PIYKLLQDLF PKAAELYERV ASNREHWTKV SHKFTIRGLP SNNSLDFL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MHHHHHHENLYFQGELSTSLYKKAGFDDDDKSDDEYTKLLHDGIQPVAAI
CC	ATOM   ---------------LSTSLYKKAGFD-------EYTKLLHDGIQPVAAI
CC	                      ************       ****************
CC	SEQRES DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV
CC	ATOM   DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV
CC	       **************************************************
CC	SEQRES KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH
CC	ATOM   KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH
CC	       **************************************************
CC	SEQRES DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF
CC	ATOM   DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF
CC	       **************************************************
CC	SEQRES DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH
CC	ATOM   DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH
CC	       **************************************************
CC	SEQRES RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
CC	ATOM   RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME
CC	       **************************************************
CC	SEQRES MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT
CC	ATOM   MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT
CC	       **************************************************
CC	SEQRES KVSHKFTIRGLPSNNSLDFLDEE
CC	ATOM   KVSHKFTIRGLPSNNSLDFL---
CC	       ********************   
SQ	SEQUENCE	373 AA;      MW;         CN;
	MHHHHHHENL YFQGELSTSL YKKAGFDDDD KSDDEYTKLL HDGIQPVAAI DSNFASFTYT
	PRSLPEDDTS MAILSMLQDM NFINNYKIDC PTLARFCLMV KKGYRDPPYH NWMHAFSVSH
	FCYLLYKNLE LTNYLEDIEI FALFISCMCH DLDHRGTNNS FQVASKSVLA ALYSSEGSVM
	ERHHFAQAIA ILNTHGCNIF DHFSRKDYQR MLDLMRDIIL ATDLAHHLRI FKDLQKMAEV
	GYDRNNKQHH RLLLCLLMTS CDLSDQTKGW KTTRKIAELI YKEFFSQGDL EKAMGNRPME
	MMDREKAYIP ELQISFMEHI AMPIYKLLQD LFPKAAELYE RVASNREHWT KVSHKFTIRG
	LPSNNSLDFL DEE
//