ID 6CYCA STANDARD; PRT; 373 AA. DT CONVERTED FROM PDB (SEQRES) 6CYC DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.540 CC R-Factor 0.186 FT #SUB 171 717 ALA A 248 794 GLN B Protein A 6 FT #SUB 171 717 ALA A 251 797 ARG B Protein B 4 FT #SUB 172 718 LEU A 251 797 ARG B Protein B 8 FT #SUB 175 721 SER A 226 772 HIS B Protein B 1 FT #SUB 175 721 SER A 230 776 ILE B Protein S 1 FT #SUB 176 722 GLU A 226 772 HIS B Protein S 5 FT #SUB 193 739 ASN A 206 752 LYS B Protein S 2 FT #SUB 198 744 ASN A 205 751 ARG B Protein S 1 FT #SUB 201 747 ASP A 205 751 ARG B Protein A 8 FT #SUB 208 754 TYR A 205 751 ARG B Protein S 11 FT #SUB 209 755 GLN A 208 754 TYR B Protein S 1 FT #SUB 209 755 GLN A 212 758 LEU B Protein S 2 FT #SUB 212 758 LEU A 209 755 GLN B Protein S 1 FT #SUB 216 762 ARG A 216 762 ARG B Protein S 2 FT #SUB 226 772 HIS A 176 722 GLU B Protein S 4 FT #SUB 229 775 ARG A 175 721 SER B Protein A 3 FT #SUB 229 775 ARG A 176 722 GLU B Protein S 8 FT #SUB 230 776 ILE A 175 721 SER B Protein S 1 FT #SUB 248 794 GLN A 171 717 ALA B Protein S 1 FT #SUB 248 794 GLN A 172 718 LEU B Protein S 4 FT #HET 23 569 LYS A 8 1008 EDO A S 5 FT #HET 26 572 PHE A 8 1008 EDO A B 2 FT #HET 109 655 TYR A 3 1003 FKJ A S 2 FT #HET 110 656 HIS A 3 1003 FKJ A S 2 FT #HET 114 660 HIS A 1 1001 ZN A S 3 FT #HET 150 696 HIS A 1 1001 ZN A S 3 FT #HET 151 697 ASP A 1 1001 ZN A S 3 FT #HET 151 697 ASP A 2 1002 MG A S 3 FT #HET 158 704 ASN A 5 1005 EDO A S 5 FT #HET 175 721 SER A 7 1007 EDO A S 6 FT #HET 176 722 GLU A 7 1007 EDO A S 1 FT #HET 187 733 GLN A 8 1008 EDO A S 2 FT #HET 189 735 ILE A 9 1009 EDO A S 3 FT #HET 193 739 ASN A 9 1009 EDO A S 8 FT #HET 208 754 TYR A 9 1009 EDO A S 5 FT #HET 212 758 LEU A 9 1009 EDO A S 2 FT #HET 222 768 THR A 3 1003 FKJ A B 5 FT #HET 222 768 THR A 6 1006 EDO A B 1 FT #HET 223 769 ASP A 3 1003 FKJ A B 1 FT #HET 223 769 ASP A 6 1006 EDO A A 3 FT #HET 224 770 LEU A 3 1003 FKJ A A 3 FT #HET 224 770 LEU A 4 1004 EDO A S 2 FT #HET 224 770 LEU A 6 1006 EDO A A 4 FT #HET 259 805 THR A 3 1003 FKJ A A 7 FT #HET 262 808 ASP A 1 1001 ZN A S 3 FT #HET 262 808 ASP A 3 1003 FKJ A S 4 FT #HET 263 809 LEU A 3 1003 FKJ A S 8 FT #HET 266 812 GLN A 3 1003 FKJ A S 5 FT #HET 276 822 ILE A 3 1003 FKJ A S 1 FT #HET 280 826 ILE A 3 1003 FKJ A S 5 FT #HET 284 830 PHE A 3 1003 FKJ A S 3 FT #HET 284 830 PHE A 4 1004 EDO A S 2 FT #HET 284 830 PHE A 5 1005 EDO A S 5 FT #HET 301 847 MET A 3 1003 FKJ A S 1 FT #HET 301 847 MET A 4 1004 EDO A S 1 FT #HET 301 847 MET A 5 1005 EDO A S 2 FT #HET 302 848 MET A 5 1005 EDO A S 1 FT #HET 313 859 GLN A 3 1003 FKJ A S 10 FT #HET 316 862 PHE A 3 1003 FKJ A S 25 FT #HET 316 862 PHE A 4 1004 EDO A S 1 FT #HET 324 870 ILE A 3 1003 FKJ A S 1 FT DISORDER 1 18 FT DISORDER 27 35 FT DISORDER 371 373 CC SEQUENCE 343 AA (ATOM); CC SLYKKAGFYT KLLHDGIQPV AAIDSNFASF TYTPRSLPED DTSMAILSML QDMNFINNYK CC IDCPTLARFC LMVKKGYRDP PYHNWMHAFS VSHFCYLLYK NLELTNYLED IEIFALFISC CC MCHDLDHRGT NNSFQVASKS VLAALYSSEG SVMERHHFAQ AIAILNTHGC NIFDHFSRKD CC YQRMLDLMRD IILATDLAHH LRIFKDLQKM AEVGYDRNNK QHHRLLLCLL MTSCDLSDQT CC KGWKTTRKIA ELIYKEFFSQ GDLEKAMGNR PMEMMDREKA YIPELQISFM EHIAMPIYKL CC LQDLFPKAAE LYERVASNRE HWTKVSHKFT IRGLPSNNSL DFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MHHHHHHENLYFQGELSTSLYKKAGFDDDDKSDDEYTKLLHDGIQPVAAI CC ATOM ------------------SLYKKAGF---------YTKLLHDGIQPVAAI CC ******** *************** CC SEQRES DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV CC ATOM DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV CC ************************************************** CC SEQRES KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH CC ATOM KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH CC ************************************************** CC SEQRES DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF CC ATOM DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF CC ************************************************** CC SEQRES DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH CC ATOM DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH CC ************************************************** CC SEQRES RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME CC ATOM RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME CC ************************************************** CC SEQRES MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT CC ATOM MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT CC ************************************************** CC SEQRES KVSHKFTIRGLPSNNSLDFLDEE CC ATOM KVSHKFTIRGLPSNNSLDFL--- CC ******************** SQ SEQUENCE 373 AA; MW; CN; MHHHHHHENL YFQGELSTSL YKKAGFDDDD KSDDEYTKLL HDGIQPVAAI DSNFASFTYT PRSLPEDDTS MAILSMLQDM NFINNYKIDC PTLARFCLMV KKGYRDPPYH NWMHAFSVSH FCYLLYKNLE LTNYLEDIEI FALFISCMCH DLDHRGTNNS FQVASKSVLA ALYSSEGSVM ERHHFAQAIA ILNTHGCNIF DHFSRKDYQR MLDLMRDIIL ATDLAHHLRI FKDLQKMAEV GYDRNNKQHH RLLLCLLMTS CDLSDQTKGW KTTRKIAELI YKEFFSQGDL EKAMGNRPME MMDREKAYIP ELQISFMEHI AMPIYKLLQD LFPKAAELYE RVASNREHWT KVSHKFTIRG LPSNNSLDFL DEE // ID 6CYCB STANDARD; PRT; 373 AA. DT CONVERTED FROM PDB (SEQRES) 6CYC DE cGMP-dependent 3',5'-cyclic phosphodiesterase OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.540 CC R-Factor 0.186 FT #SUB 171 717 ALA B 248 794 GLN A Protein B 1 FT #SUB 172 718 LEU B 248 794 GLN A Protein A 4 FT #SUB 175 721 SER B 229 775 ARG A Protein A 3 FT #SUB 175 721 SER B 230 776 ILE A Protein S 1 FT #SUB 176 722 GLU B 226 772 HIS A Protein S 4 FT #SUB 176 722 GLU B 229 775 ARG A Protein S 8 FT #SUB 205 751 ARG B 198 744 ASN A Protein S 1 FT #SUB 205 751 ARG B 201 747 ASP A Protein S 8 FT #SUB 205 751 ARG B 208 754 TYR A Protein S 11 FT #SUB 206 752 LYS B 193 739 ASN A Protein S 2 FT #SUB 208 754 TYR B 209 755 GLN A Protein S 1 FT #SUB 209 755 GLN B 212 758 LEU A Protein S 1 FT #SUB 212 758 LEU B 209 755 GLN A Protein S 2 FT #SUB 216 762 ARG B 216 762 ARG A Protein S 2 FT #SUB 226 772 HIS B 175 721 SER A Protein S 1 FT #SUB 226 772 HIS B 176 722 GLU A Protein S 5 FT #SUB 230 776 ILE B 175 721 SER A Protein S 1 FT #SUB 248 794 GLN B 171 717 ALA A Protein S 6 FT #SUB 251 797 ARG B 171 717 ALA A Protein S 4 FT #SUB 251 797 ARG B 172 718 LEU A Protein S 8 FT #HET 53 599 ASN B 16 1007 EDO B S 4 FT #HET 58 604 THR B 16 1007 EDO B B 1 FT #HET 59 605 TYR B 16 1007 EDO B A 8 FT #HET 60 606 THR B 16 1007 EDO B A 9 FT #HET 109 655 TYR B 12 1003 FKJ B S 2 FT #HET 110 656 HIS B 12 1003 FKJ B S 2 FT #HET 114 660 HIS B 10 1001 ZN B S 3 FT #HET 150 696 HIS B 10 1001 ZN B S 3 FT #HET 151 697 ASP B 10 1001 ZN B S 3 FT #HET 151 697 ASP B 11 1002 MG B S 3 FT #HET 158 704 ASN B 14 1005 EDO B S 4 FT #HET 205 751 ARG B 9 1009 EDO A A 4 FT #HET 206 752 LYS B 9 1009 EDO A B 1 FT #HET 209 755 GLN B 9 1009 EDO A S 2 FT #HET 222 768 THR B 12 1003 FKJ B B 6 FT #HET 222 768 THR B 13 1004 EDO B B 2 FT #HET 223 769 ASP B 12 1003 FKJ B B 1 FT #HET 223 769 ASP B 13 1004 EDO B A 3 FT #HET 224 770 LEU B 12 1003 FKJ B A 4 FT #HET 224 770 LEU B 13 1004 EDO B A 5 FT #HET 224 770 LEU B 15 1006 EDO B S 1 FT #HET 226 772 HIS B 7 1007 EDO A S 2 FT #HET 228 774 LEU B 17 1008 EDO B S 1 FT #HET 230 776 ILE B 7 1007 EDO A S 3 FT #HET 231 777 PHE B 17 1008 EDO B S 6 FT #HET 251 797 ARG B 7 1007 EDO A A 7 FT #HET 252 798 LEU B 7 1007 EDO A A 3 FT #HET 255 801 CYS B 7 1007 EDO A S 2 FT #HET 259 805 THR B 12 1003 FKJ B A 5 FT #HET 262 808 ASP B 10 1001 ZN B S 3 FT #HET 262 808 ASP B 12 1003 FKJ B S 4 FT #HET 263 809 LEU B 12 1003 FKJ B S 8 FT #HET 266 812 GLN B 12 1003 FKJ B S 5 FT #HET 276 822 ILE B 12 1003 FKJ B S 1 FT #HET 280 826 ILE B 12 1003 FKJ B S 3 FT #HET 284 830 PHE B 12 1003 FKJ B S 2 FT #HET 284 830 PHE B 14 1005 EDO B S 5 FT #HET 284 830 PHE B 15 1006 EDO B S 1 FT #HET 299 845 MET B 14 1005 EDO B S 1 FT #HET 301 847 MET B 14 1005 EDO B S 1 FT #HET 301 847 MET B 15 1006 EDO B S 2 FT #HET 302 848 MET B 14 1005 EDO B S 2 FT #HET 313 859 GLN B 12 1003 FKJ B S 1 FT #HET 316 862 PHE B 12 1003 FKJ B S 29 FT #HET 316 862 PHE B 15 1006 EDO B S 1 FT #HET 319 865 HIS B 17 1008 EDO B B 4 FT #HET 320 866 ILE B 15 1006 EDO B S 1 FT #HET 323 869 PRO B 17 1008 EDO B S 1 FT #HET 324 870 ILE B 12 1003 FKJ B S 1 FT DISORDER 1 15 FT DISORDER 28 34 FT DISORDER 371 373 CC SEQUENCE 348 AA (ATOM); CC LSTSLYKKAG FDEYTKLLHD GIQPVAAIDS NFASFTYTPR SLPEDDTSMA ILSMLQDMNF CC INNYKIDCPT LARFCLMVKK GYRDPPYHNW MHAFSVSHFC YLLYKNLELT NYLEDIEIFA CC LFISCMCHDL DHRGTNNSFQ VASKSVLAAL YSSEGSVMER HHFAQAIAIL NTHGCNIFDH CC FSRKDYQRML DLMRDIILAT DLAHHLRIFK DLQKMAEVGY DRNNKQHHRL LLCLLMTSCD CC LSDQTKGWKT TRKIAELIYK EFFSQGDLEK AMGNRPMEMM DREKAYIPEL QISFMEHIAM CC PIYKLLQDLF PKAAELYERV ASNREHWTKV SHKFTIRGLP SNNSLDFL CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MHHHHHHENLYFQGELSTSLYKKAGFDDDDKSDDEYTKLLHDGIQPVAAI CC ATOM ---------------LSTSLYKKAGFD-------EYTKLLHDGIQPVAAI CC ************ **************** CC SEQRES DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV CC ATOM DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMV CC ************************************************** CC SEQRES KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH CC ATOM KKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCH CC ************************************************** CC SEQRES DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF CC ATOM DLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIF CC ************************************************** CC SEQRES DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH CC ATOM DHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHH CC ************************************************** CC SEQRES RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME CC ATOM RLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPME CC ************************************************** CC SEQRES MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT CC ATOM MMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWT CC ************************************************** CC SEQRES KVSHKFTIRGLPSNNSLDFLDEE CC ATOM KVSHKFTIRGLPSNNSLDFL--- CC ******************** SQ SEQUENCE 373 AA; MW; CN; MHHHHHHENL YFQGELSTSL YKKAGFDDDD KSDDEYTKLL HDGIQPVAAI DSNFASFTYT PRSLPEDDTS MAILSMLQDM NFINNYKIDC PTLARFCLMV KKGYRDPPYH NWMHAFSVSH FCYLLYKNLE LTNYLEDIEI FALFISCMCH DLDHRGTNNS FQVASKSVLA ALYSSEGSVM ERHHFAQAIA ILNTHGCNIF DHFSRKDYQR MLDLMRDIIL ATDLAHHLRI FKDLQKMAEV GYDRNNKQHH RLLLCLLMTS CDLSDQTKGW KTTRKIAELI YKEFFSQGDL EKAMGNRPME MMDREKAYIP ELQISFMEHI AMPIYKLLQD LFPKAAELYE RVASNREHWT KVSHKFTIRG LPSNNSLDFL DEE //