ID 6CIFA STANDARD; PRT; 440 AA. DT CONVERTED FROM PDB (SEQRES) 6CIF DE Nitric oxide synthase, endothelial OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.192 FT #SUB 29 69 PRO A 58 98 ARG B Protein S 2 FT #SUB 29 69 PRO A 60 100 LEU B Protein S 1 FT #SUB 34 74 TRP A 64 104 VAL B Protein S 5 FT #SUB 34 74 TRP A 65 105 PHE B Protein S 3 FT #SUB 34 74 TRP A 331 371 HIS B Protein B 5 FT #SUB 35 75 GLU A 330 370 PRO B Protein S 6 FT #SUB 35 75 GLU A 331 371 HIS B Protein B 2 FT #SUB 48 88 ALA A 57 97 ARG B Protein A 6 FT #SUB 49 89 GLN A 57 97 ARG B Protein B 4 FT #SUB 51 91 ASP A 56 96 PRO B Protein A 7 FT #SUB 51 91 ASP A 57 97 ARG B Protein S 3 FT #SUB 52 92 GLY A 56 96 PRO B Protein B 3 FT #SUB 54 94 CYS A 54 94 CYS B Protein S 1 FT #SUB 54 94 CYS A 55 95 THR B Protein A 4 FT #SUB 54 94 CYS A 56 96 PRO B Protein B 4 FT #SUB 54 94 CYS A 59 99 CYS B Protein S 2 FT #SUB 55 95 THR A 54 94 CYS B Protein B 2 FT #SUB 56 96 PRO A 51 91 ASP B Protein A 7 FT #SUB 56 96 PRO A 52 92 GLY B Protein B 3 FT #SUB 56 96 PRO A 54 94 CYS B Protein A 5 FT #SUB 57 97 ARG A 45 85 SER B Protein S 3 FT #SUB 57 97 ARG A 46 86 ALA B Protein S 4 FT #SUB 57 97 ARG A 48 88 ALA B Protein A 6 FT #SUB 57 97 ARG A 427 467 TYR B Protein B 2 FT #SUB 58 98 ARG A 29 69 PRO B Protein S 1 FT #SUB 58 98 ARG A 425 465 VAL B Protein S 1 FT #SUB 58 98 ARG A 426 466 ASN B Protein A 3 FT #SUB 59 99 CYS A 54 94 CYS B Protein S 2 FT #SUB 59 99 CYS A 59 99 CYS B Protein S 1 FT #SUB 59 99 CYS A 425 465 VAL B Protein B 3 FT #SUB 59 99 CYS A 426 466 ASN B Protein A 7 FT #SUB 60 100 LEU A 425 465 VAL B Protein S 2 FT #SUB 62 102 SER A 405 445 TRP B Protein S 3 FT #SUB 62 102 SER A 423 463 GLU B Protein A 3 FT #SUB 62 102 SER A 424 464 MET B Protein S 5 FT #SUB 63 103 LEU A 30 70 ARG B Protein S 1 FT #SUB 63 103 LEU A 423 463 GLU B Protein A 6 FT #SUB 63 103 LEU A 424 464 MET B Protein S 1 FT #SUB 64 104 VAL A 34 74 TRP B Protein S 4 FT #SUB 64 104 VAL A 423 463 GLU B Protein A 5 FT #SUB 65 105 PHE A 34 74 TRP B Protein S 3 FT #SUB 324 364 THR A 415 455 SER B Protein S 1 FT #SUB 325 365 ARG A 415 455 SER B Protein S 2 FT #SUB 325 365 ARG A 420 460 PHE B Protein S 3 FT #SUB 329 369 ASP A 421 461 HIS B Protein S 3 FT #SUB 330 370 PRO A 35 75 GLU B Protein S 8 FT #SUB 330 370 PRO A 421 461 HIS B Protein S 1 FT #SUB 331 371 HIS A 34 74 TRP B Protein S 5 FT #SUB 331 371 HIS A 35 75 GLU B Protein S 2 FT #SUB 331 371 HIS A 421 461 HIS B Protein S 1 FT #SUB 336 376 LEU A 416 456 LEU B Protein S 1 FT #SUB 350 390 THR A 379 419 ASP B Protein A 8 FT #SUB 350 390 THR A 381 421 HIS B Protein S 1 FT #SUB 351 391 SER A 367 407 LEU B Protein B 1 FT #SUB 351 391 SER A 371 411 GLN B Protein S 2 FT #SUB 351 391 SER A 379 419 ASP B Protein A 3 FT #SUB 352 392 SER A 364 404 VAL B Protein B 1 FT #SUB 353 393 LEU A 360 400 VAL B Protein S 1 FT #SUB 353 393 LEU A 363 403 ASN B Protein S 2 FT #SUB 353 393 LEU A 364 404 VAL B Protein S 2 FT #SUB 353 393 LEU A 367 407 LEU B Protein S 1 FT #SUB 353 393 LEU A 380 420 HIS B Protein S 1 FT #SUB 355 395 LYS A 381 421 HIS B Protein S 3 FT #SUB 355 395 LYS A 416 456 LEU B Protein B 2 FT #SUB 356 396 ASP A 360 400 VAL B Protein S 1 FT #SUB 356 396 ASP A 380 420 HIS B Protein S 3 FT #SUB 356 396 ASP A 381 421 HIS B Protein S 5 FT #SUB 356 396 ASP A 413 453 SER B Protein S 4 FT #SUB 357 397 LYS A 360 400 VAL B Protein S 1 FT #SUB 357 397 LYS A 361 401 GLU B Protein S 1 FT #SUB 357 397 LYS A 364 404 VAL B Protein S 1 FT #SUB 359 399 ALA A 416 456 LEU B Protein S 1 FT #SUB 360 400 VAL A 353 393 LEU B Protein B 1 FT #SUB 360 400 VAL A 357 397 LYS B Protein S 1 FT #SUB 361 401 GLU A 357 397 LYS B Protein S 1 FT #SUB 363 403 ASN A 353 393 LEU B Protein A 2 FT #SUB 364 404 VAL A 353 393 LEU B Protein A 2 FT #SUB 364 404 VAL A 357 397 LYS B Protein S 1 FT #SUB 367 407 LEU A 351 391 SER B Protein S 1 FT #SUB 367 407 LEU A 353 393 LEU B Protein S 1 FT #SUB 371 411 GLN A 351 391 SER B Protein S 2 FT #SUB 379 419 ASP A 350 390 THR B Protein S 7 FT #SUB 379 419 ASP A 351 391 SER B Protein S 2 FT #SUB 380 420 HIS A 353 393 LEU B Protein S 1 FT #SUB 380 420 HIS A 356 396 ASP B Protein S 3 FT #SUB 381 421 HIS A 350 390 THR B Protein S 2 FT #SUB 381 421 HIS A 353 393 LEU B Protein S 1 FT #SUB 381 421 HIS A 355 395 LYS B Protein S 3 FT #SUB 381 421 HIS A 356 396 ASP B Protein S 6 FT #SUB 405 445 TRP A 62 102 SER B Protein S 2 FT #SUB 405 445 TRP A 406 446 ALA B Protein S 3 FT #SUB 406 446 ALA A 405 445 TRP B Protein A 3 FT #SUB 411 451 PRO A 413 453 SER B Protein B 1 FT #SUB 411 451 PRO A 414 454 GLY B Protein B 3 FT #SUB 411 451 PRO A 415 455 SER B Protein A 4 FT #SUB 412 452 ILE A 413 453 SER B Protein B 1 FT #SUB 413 453 SER A 356 396 ASP B Protein S 6 FT #SUB 413 453 SER A 411 451 PRO B Protein B 1 FT #SUB 413 453 SER A 412 452 ILE B Protein B 2 FT #SUB 413 453 SER A 413 453 SER B Protein B 1 FT #SUB 414 454 GLY A 411 451 PRO B Protein B 3 FT #SUB 415 455 SER A 324 364 THR B Protein S 1 FT #SUB 415 455 SER A 325 365 ARG B Protein S 2 FT #SUB 415 455 SER A 411 451 PRO B Protein A 7 FT #SUB 416 456 LEU A 336 376 LEU B Protein S 1 FT #SUB 416 456 LEU A 355 395 LYS B Protein A 3 FT #SUB 416 456 LEU A 359 399 ALA B Protein S 1 FT #SUB 420 460 PHE A 325 365 ARG B Protein S 4 FT #SUB 421 461 HIS A 325 365 ARG B Protein S 2 FT #SUB 421 461 HIS A 329 369 ASP B Protein S 4 FT #SUB 421 461 HIS A 331 371 HIS B Protein S 2 FT #SUB 423 463 GLU A 62 102 SER B Protein A 3 FT #SUB 423 463 GLU A 63 103 LEU B Protein S 5 FT #SUB 423 463 GLU A 64 104 VAL B Protein S 5 FT #SUB 424 464 MET A 62 102 SER B Protein B 4 FT #SUB 425 465 VAL A 58 98 ARG B Protein S 1 FT #SUB 425 465 VAL A 59 99 CYS B Protein A 2 FT #SUB 425 465 VAL A 60 100 LEU B Protein S 2 FT #SUB 426 466 ASN A 58 98 ARG B Protein B 3 FT #SUB 426 466 ASN A 59 99 CYS B Protein B 5 FT #SUB 427 467 TYR A 57 97 ARG B Protein S 1 FT #SUB 346 386 ASP A 217 257 GLN C Protein S 5 FT #SUB 348 388 ARG A 217 257 GLN C Protein S 9 FT #HET 54 94 CYS A 6 506 ZN A S 2 FT #HET 59 99 CYS A 6 506 ZN A A 3 FT #HET 62 102 SER A 2 502 H4B A B 4 FT #HET 64 104 VAL A 2 502 H4B A S 1 FT #HET 127 167 GLU A 7 507 GOL A S 18 FT #HET 138 178 TRP A 1 501 HEM A S 32 FT #HET 141 181 ALA A 1 501 HEM A S 3 FT #HET 142 182 PRO A 1 501 HEM A A 2 FT #HET 143 183 ARG A 1 501 HEM A A 18 FT #HET 144 184 CYS A 1 501 HEM A A 15 FT #HET 145 185 VAL A 1 501 HEM A S 2 FT #HET 146 186 GLY A 1 501 HEM A B 3 FT #HET 186 226 SER A 1 501 HEM A S 2 FT #HET 207 247 GLN A 3 503 F2J A S 1 FT #HET 207 247 GLN A 8 508 CL A S 1 FT #HET 294 334 PRO A 3 503 F2J A A 12 FT #HET 296 336 VAL A 3 503 F2J A A 8 FT #HET 313 353 PHE A 1 501 HEM A S 11 FT #HET 313 353 PHE A 3 503 F2J A A 6 FT #HET 314 354 SER A 1 501 HEM A B 1 FT #HET 314 354 SER A 3 503 F2J A B 4 FT #HET 315 355 GLY A 1 501 HEM A B 1 FT #HET 315 355 GLY A 3 503 F2J A B 3 FT #HET 316 356 TRP A 1 501 HEM A A 16 FT #HET 316 356 TRP A 3 503 F2J A B 2 FT #HET 317 357 TYR A 8 508 CL A S 3 FT #HET 318 358 MET A 1 501 HEM A S 1 FT #HET 321 361 GLU A 1 501 HEM A S 4 FT #HET 321 361 GLU A 3 503 F2J A S 11 FT #HET 325 365 ARG A 2 502 H4B A S 9 FT #HET 326 366 ASN A 8 508 CL A S 2 FT #HET 337 377 GLU A 5 505 BTB A S 6 FT #HET 342 382 CYS A 4 504 BTB A B 2 FT #HET 344 384 ASP A 4 504 BTB A S 19 FT #HET 405 445 TRP A 11 502 H4B B S 4 FT #HET 406 446 ALA A 2 502 H4B A B 3 FT #HET 407 447 TRP A 2 502 H4B A A 26 FT #HET 420 460 PHE A 11 502 H4B B A 12 FT #HET 421 461 HIS A 11 502 H4B B B 3 FT #HET 422 462 GLN A 11 502 H4B B B 3 FT #HET 423 463 GLU A 11 502 H4B B A 2 FT #HET 433 473 PHE A 1 501 HEM A S 4 FT #HET 435 475 TYR A 1 501 HEM A S 3 FT DISORDER 1 27 FT DISORDER 70 78 CC SEQUENCE 404 AA (ATOM); CC FPRVKNWEVG SITYDTLSAQ AQQDGPCTPR RCLGSLVFPR KLAPEQLLSQ ARDFINQYYS CC SIKRSGSQAH EQRLQEVEAE VAATGTYQLR ESELVFGAKQ AWRNAPRCVG RIQWGKLQVF CC DARDCRSAQE MFTYICNHIK YATNRGNLRS AITVFPQRCP GRGDFRIWNS QLVRYAGYRQ CC QDGSVRGDPA NVEITELCIQ HGWTPGNGRF DVLPLLLQAP DEPPELFLLP PELVLEVPLE CC HPTLEWFAAL GLRWYALPAV SNMLLEIGGL EFPAAPFSGW YMSTEIGTRN LCDPHRYNIL CC EDVAVCMDLD TRTTSSLWKD KAAVEINVAV LHSYQLAKVT IVDHHAATAS FMKHLENEQK CC ARGGCPADWA WIVPPISGSL TPVFHQEMVN YFLSPAFRYQ PDPW CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES APASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQ CC ATOM ---------------------------FPRVKNWEVGSITYDTLSAQAQQ CC *********************** CC SEQRES DGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKR CC ATOM DGPCTPRRCLGSLVFPRKL---------APEQLLSQARDFINQYYSSIKR CC ******************* ********************** CC SEQRES SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ATOM SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ************************************************** CC SEQRES GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ATOM GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ************************************************** CC SEQRES FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ATOM FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ************************************************** CC SEQRES LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ATOM LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ************************************************** CC SEQRES LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ATOM LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ************************************************** CC SEQRES SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ATOM SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ************************************************** CC SEQRES CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC ATOM CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC **************************************** SQ SEQUENCE 440 AA; MW; CN; APASLLPPAP EHSPPSSPLT QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW // ID 6CIFB STANDARD; PRT; 440 AA. DT CONVERTED FROM PDB (SEQRES) 6CIF DE Nitric oxide synthase, endothelial OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.192 FT #SUB 29 69 PRO B 58 98 ARG A Protein S 1 FT #SUB 30 70 ARG B 63 103 LEU A Protein B 1 FT #SUB 34 74 TRP B 64 104 VAL A Protein S 4 FT #SUB 34 74 TRP B 65 105 PHE A Protein S 3 FT #SUB 34 74 TRP B 331 371 HIS A Protein B 5 FT #SUB 35 75 GLU B 330 370 PRO A Protein S 8 FT #SUB 35 75 GLU B 331 371 HIS A Protein B 2 FT #SUB 45 85 SER B 57 97 ARG A Protein B 3 FT #SUB 46 86 ALA B 57 97 ARG A Protein B 4 FT #SUB 48 88 ALA B 57 97 ARG A Protein A 6 FT #SUB 51 91 ASP B 56 96 PRO A Protein A 7 FT #SUB 52 92 GLY B 56 96 PRO A Protein B 3 FT #SUB 54 94 CYS B 54 94 CYS A Protein S 1 FT #SUB 54 94 CYS B 55 95 THR A Protein B 2 FT #SUB 54 94 CYS B 56 96 PRO A Protein B 5 FT #SUB 54 94 CYS B 59 99 CYS A Protein S 2 FT #SUB 55 95 THR B 54 94 CYS A Protein B 4 FT #SUB 56 96 PRO B 51 91 ASP A Protein A 7 FT #SUB 56 96 PRO B 52 92 GLY A Protein B 3 FT #SUB 56 96 PRO B 54 94 CYS A Protein A 4 FT #SUB 57 97 ARG B 48 88 ALA A Protein A 6 FT #SUB 57 97 ARG B 49 89 GLN A Protein S 4 FT #SUB 57 97 ARG B 51 91 ASP A Protein S 3 FT #SUB 57 97 ARG B 427 467 TYR A Protein B 1 FT #SUB 58 98 ARG B 29 69 PRO A Protein S 2 FT #SUB 58 98 ARG B 425 465 VAL A Protein S 1 FT #SUB 58 98 ARG B 426 466 ASN A Protein A 3 FT #SUB 59 99 CYS B 54 94 CYS A Protein S 2 FT #SUB 59 99 CYS B 59 99 CYS A Protein S 1 FT #SUB 59 99 CYS B 425 465 VAL A Protein B 2 FT #SUB 59 99 CYS B 426 466 ASN A Protein A 5 FT #SUB 60 100 LEU B 29 69 PRO A Protein S 1 FT #SUB 60 100 LEU B 425 465 VAL A Protein S 2 FT #SUB 62 102 SER B 405 445 TRP A Protein S 2 FT #SUB 62 102 SER B 423 463 GLU A Protein A 3 FT #SUB 62 102 SER B 424 464 MET A Protein S 4 FT #SUB 63 103 LEU B 423 463 GLU A Protein A 5 FT #SUB 64 104 VAL B 34 74 TRP A Protein S 5 FT #SUB 64 104 VAL B 423 463 GLU A Protein A 5 FT #SUB 65 105 PHE B 34 74 TRP A Protein S 3 FT #SUB 324 364 THR B 415 455 SER A Protein S 1 FT #SUB 325 365 ARG B 415 455 SER A Protein S 2 FT #SUB 325 365 ARG B 420 460 PHE A Protein S 4 FT #SUB 325 365 ARG B 421 461 HIS A Protein S 2 FT #SUB 329 369 ASP B 421 461 HIS A Protein S 4 FT #SUB 330 370 PRO B 35 75 GLU A Protein S 6 FT #SUB 331 371 HIS B 34 74 TRP A Protein S 5 FT #SUB 331 371 HIS B 35 75 GLU A Protein S 2 FT #SUB 331 371 HIS B 421 461 HIS A Protein S 2 FT #SUB 336 376 LEU B 416 456 LEU A Protein S 1 FT #SUB 350 390 THR B 379 419 ASP A Protein A 7 FT #SUB 350 390 THR B 381 421 HIS A Protein S 2 FT #SUB 351 391 SER B 367 407 LEU A Protein B 1 FT #SUB 351 391 SER B 371 411 GLN A Protein S 2 FT #SUB 351 391 SER B 379 419 ASP A Protein B 2 FT #SUB 353 393 LEU B 360 400 VAL A Protein S 1 FT #SUB 353 393 LEU B 363 403 ASN A Protein S 2 FT #SUB 353 393 LEU B 364 404 VAL A Protein S 2 FT #SUB 353 393 LEU B 367 407 LEU A Protein S 1 FT #SUB 353 393 LEU B 380 420 HIS A Protein S 1 FT #SUB 353 393 LEU B 381 421 HIS A Protein S 1 FT #SUB 355 395 LYS B 381 421 HIS A Protein S 3 FT #SUB 355 395 LYS B 416 456 LEU A Protein A 3 FT #SUB 356 396 ASP B 380 420 HIS A Protein S 3 FT #SUB 356 396 ASP B 381 421 HIS A Protein S 6 FT #SUB 356 396 ASP B 413 453 SER A Protein A 6 FT #SUB 357 397 LYS B 360 400 VAL A Protein S 1 FT #SUB 357 397 LYS B 361 401 GLU A Protein S 1 FT #SUB 357 397 LYS B 364 404 VAL A Protein S 1 FT #SUB 359 399 ALA B 416 456 LEU A Protein S 1 FT #SUB 360 400 VAL B 353 393 LEU A Protein B 1 FT #SUB 360 400 VAL B 356 396 ASP A Protein S 1 FT #SUB 360 400 VAL B 357 397 LYS A Protein S 1 FT #SUB 361 401 GLU B 357 397 LYS A Protein S 1 FT #SUB 363 403 ASN B 353 393 LEU A Protein A 2 FT #SUB 364 404 VAL B 352 392 SER A Protein S 1 FT #SUB 364 404 VAL B 353 393 LEU A Protein A 2 FT #SUB 364 404 VAL B 357 397 LYS A Protein S 1 FT #SUB 367 407 LEU B 351 391 SER A Protein S 1 FT #SUB 367 407 LEU B 353 393 LEU A Protein S 1 FT #SUB 371 411 GLN B 351 391 SER A Protein S 2 FT #SUB 379 419 ASP B 350 390 THR A Protein S 8 FT #SUB 379 419 ASP B 351 391 SER A Protein S 3 FT #SUB 380 420 HIS B 353 393 LEU A Protein S 1 FT #SUB 380 420 HIS B 356 396 ASP A Protein S 3 FT #SUB 381 421 HIS B 350 390 THR A Protein S 1 FT #SUB 381 421 HIS B 355 395 LYS A Protein S 3 FT #SUB 381 421 HIS B 356 396 ASP A Protein S 5 FT #SUB 405 445 TRP B 62 102 SER A Protein S 3 FT #SUB 405 445 TRP B 406 446 ALA A Protein S 3 FT #SUB 406 446 ALA B 405 445 TRP A Protein A 3 FT #SUB 411 451 PRO B 413 453 SER A Protein B 1 FT #SUB 411 451 PRO B 414 454 GLY A Protein B 3 FT #SUB 411 451 PRO B 415 455 SER A Protein A 7 FT #SUB 412 452 ILE B 413 453 SER A Protein A 2 FT #SUB 413 453 SER B 356 396 ASP A Protein S 4 FT #SUB 413 453 SER B 411 451 PRO A Protein B 1 FT #SUB 413 453 SER B 412 452 ILE A Protein B 1 FT #SUB 413 453 SER B 413 453 SER A Protein B 1 FT #SUB 414 454 GLY B 411 451 PRO A Protein B 3 FT #SUB 415 455 SER B 324 364 THR A Protein S 1 FT #SUB 415 455 SER B 325 365 ARG A Protein S 2 FT #SUB 415 455 SER B 411 451 PRO A Protein A 4 FT #SUB 416 456 LEU B 336 376 LEU A Protein S 1 FT #SUB 416 456 LEU B 355 395 LYS A Protein S 2 FT #SUB 416 456 LEU B 359 399 ALA A Protein S 1 FT #SUB 420 460 PHE B 325 365 ARG A Protein S 3 FT #SUB 421 461 HIS B 329 369 ASP A Protein S 3 FT #SUB 421 461 HIS B 330 370 PRO A Protein S 1 FT #SUB 421 461 HIS B 331 371 HIS A Protein S 1 FT #SUB 423 463 GLU B 62 102 SER A Protein A 3 FT #SUB 423 463 GLU B 63 103 LEU A Protein S 6 FT #SUB 423 463 GLU B 64 104 VAL A Protein S 5 FT #SUB 424 464 MET B 62 102 SER A Protein B 5 FT #SUB 424 464 MET B 63 103 LEU A Protein B 1 FT #SUB 425 465 VAL B 58 98 ARG A Protein S 1 FT #SUB 425 465 VAL B 59 99 CYS A Protein A 3 FT #SUB 425 465 VAL B 60 100 LEU A Protein S 2 FT #SUB 426 466 ASN B 58 98 ARG A Protein B 3 FT #SUB 426 466 ASN B 59 99 CYS A Protein A 7 FT #SUB 427 467 TYR B 57 97 ARG A Protein A 2 FT #SUB 281 321 GLU B 245 285 ARG C Protein S 2 FT #SUB 281 321 GLU B 286 326 LEU C Protein B 1 FT #SUB 281 321 GLU B 338 378 ASP C Protein A 8 FT #SUB 282 322 TRP B 338 378 ASP C Protein A 4 FT #SUB 282 322 TRP B 341 381 VAL C Protein S 3 FT #SUB 282 322 TRP B 342 382 CYS C Protein S 1 FT #SUB 284 324 ALA B 285 325 ALA C Protein A 2 FT #SUB 285 325 ALA B 342 382 CYS C Protein S 1 FT #SUB 344 384 ASP B 348 388 ARG C Protein S 9 FT #SUB 372 412 LEU B 243 283 ASN C Protein S 1 FT #SUB 374 414 LYS B 243 283 ASN C Protein S 1 FT #HET 54 94 CYS B 6 506 ZN A S 2 FT #HET 59 99 CYS B 6 506 ZN A A 3 FT #HET 62 102 SER B 11 502 H4B B B 4 FT #HET 64 104 VAL B 11 502 H4B B S 2 FT #HET 138 178 TRP B 10 501 HEM B S 35 FT #HET 141 181 ALA B 10 501 HEM B S 3 FT #HET 142 182 PRO B 10 501 HEM B A 2 FT #HET 143 183 ARG B 10 501 HEM B A 14 FT #HET 144 184 CYS B 10 501 HEM B A 15 FT #HET 145 185 VAL B 10 501 HEM B S 2 FT #HET 146 186 GLY B 10 501 HEM B B 4 FT #HET 186 226 SER B 10 501 HEM B S 2 FT #HET 207 247 GLN B 12 503 F2J B S 1 FT #HET 207 247 GLN B 16 507 CL B S 1 FT #HET 210 250 ARG B 16 507 CL B S 1 FT #HET 257 297 ASP B 14 505 BTB B B 2 FT #HET 258 298 GLU B 14 505 BTB B S 20 FT #HET 279 319 THR B 13 504 BTB B A 4 FT #HET 279 319 THR B 17 508 GD B B 2 FT #HET 281 321 GLU B 13 504 BTB B S 7 FT #HET 281 321 GLU B 17 508 GD B S 2 FT #HET 291 331 TYR B 16 507 CL B S 1 FT #HET 294 334 PRO B 12 503 F2J B A 8 FT #HET 296 336 VAL B 12 503 F2J B A 9 FT #HET 313 353 PHE B 10 501 HEM B S 14 FT #HET 313 353 PHE B 12 503 F2J B A 5 FT #HET 314 354 SER B 10 501 HEM B B 1 FT #HET 314 354 SER B 12 503 F2J B B 3 FT #HET 315 355 GLY B 10 501 HEM B B 1 FT #HET 315 355 GLY B 12 503 F2J B B 3 FT #HET 316 356 TRP B 10 501 HEM B A 17 FT #HET 316 356 TRP B 12 503 F2J B B 2 FT #HET 317 357 TYR B 16 507 CL B S 3 FT #HET 318 358 MET B 10 501 HEM B S 1 FT #HET 321 361 GLU B 10 501 HEM B S 4 FT #HET 321 361 GLU B 12 503 F2J B S 11 FT #HET 325 365 ARG B 11 502 H4B B S 6 FT #HET 326 366 ASN B 16 507 CL B S 3 FT #HET 334 374 ASN B 15 506 BTB B B 1 FT #HET 338 378 ASP B 15 506 BTB B S 18 FT #HET 344 384 ASP B 22 505 BTB C S 4 FT #HET 405 445 TRP B 2 502 H4B A S 3 FT #HET 406 446 ALA B 11 502 H4B B B 4 FT #HET 407 447 TRP B 10 501 HEM B S 4 FT #HET 407 447 TRP B 11 502 H4B B A 43 FT #HET 420 460 PHE B 2 502 H4B A A 11 FT #HET 421 461 HIS B 2 502 H4B A B 1 FT #HET 422 462 GLN B 2 502 H4B A B 2 FT #HET 423 463 GLU B 2 502 H4B A A 3 FT #HET 433 473 PHE B 10 501 HEM B S 7 FT #HET 435 475 TYR B 10 501 HEM B S 3 FT DISORDER 1 26 FT DISORDER 68 78 CC SEQUENCE 403 AA (ATOM); CC KFPRVKNWEV GSITYDTLSA QAQQDGPCTP RRCLGSLVFP RAPEQLLSQA RDFINQYYSS CC IKRSGSQAHE QRLQEVEAEV AATGTYQLRE SELVFGAKQA WRNAPRCVGR IQWGKLQVFD CC ARDCRSAQEM FTYICNHIKY ATNRGNLRSA ITVFPQRCPG RGDFRIWNSQ LVRYAGYRQQ CC DGSVRGDPAN VEITELCIQH GWTPGNGRFD VLPLLLQAPD EPPELFLLPP ELVLEVPLEH CC PTLEWFAALG LRWYALPAVS NMLLEIGGLE FPAAPFSGWY MSTEIGTRNL CDPHRYNILE CC DVAVCMDLDT RTTSSLWKDK AAVEINVAVL HSYQLAKVTI VDHHAATASF MKHLENEQKA CC RGGCPADWAW IVPPISGSLT PVFHQEMVNY FLSPAFRYQP DPW CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES APASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQ CC ATOM --------------------------KFPRVKNWEVGSITYDTLSAQAQQ CC ************************ CC SEQRES DGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKR CC ATOM DGPCTPRRCLGSLVFPR-----------APEQLLSQARDFINQYYSSIKR CC ***************** ********************** CC SEQRES SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ATOM SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ************************************************** CC SEQRES GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ATOM GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ************************************************** CC SEQRES FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ATOM FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ************************************************** CC SEQRES LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ATOM LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ************************************************** CC SEQRES LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ATOM LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ************************************************** CC SEQRES SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ATOM SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ************************************************** CC SEQRES CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC ATOM CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC **************************************** SQ SEQUENCE 440 AA; MW; CN; APASLLPPAP EHSPPSSPLT QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW // ID 6CIFC STANDARD; PRT; 440 AA. DT CONVERTED FROM PDB (SEQRES) 6CIF DE Nitric oxide synthase, endothelial OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.192 FT #SUB 217 257 GLN C 346 386 ASP A Protein S 5 FT #SUB 217 257 GLN C 348 388 ARG A Protein S 9 FT #SUB 243 283 ASN C 372 412 LEU B Protein S 1 FT #SUB 243 283 ASN C 374 414 LYS B Protein S 1 FT #SUB 245 285 ARG C 281 321 GLU B Protein S 2 FT #SUB 285 325 ALA C 284 324 ALA B Protein A 2 FT #SUB 286 326 LEU C 281 321 GLU B Protein S 1 FT #SUB 338 378 ASP C 281 321 GLU B Protein S 8 FT #SUB 338 378 ASP C 282 322 TRP B Protein A 4 FT #SUB 341 381 VAL C 282 322 TRP B Protein S 3 FT #SUB 342 382 CYS C 282 322 TRP B Protein S 1 FT #SUB 342 382 CYS C 285 325 ALA B Protein S 1 FT #SUB 348 388 ARG C 344 384 ASP B Protein S 9 FT #SUB 29 69 PRO C 60 100 LEU D Protein S 1 FT #SUB 30 70 ARG C 63 103 LEU D Protein B 1 FT #SUB 30 70 ARG C 68 108 LYS D Protein S 5 FT #SUB 34 74 TRP C 64 104 VAL D Protein S 6 FT #SUB 34 74 TRP C 65 105 PHE D Protein S 2 FT #SUB 34 74 TRP C 331 371 HIS D Protein B 5 FT #SUB 35 75 GLU C 330 370 PRO D Protein S 4 FT #SUB 35 75 GLU C 331 371 HIS D Protein B 2 FT #SUB 45 85 SER C 57 97 ARG D Protein B 1 FT #SUB 46 86 ALA C 57 97 ARG D Protein B 4 FT #SUB 48 88 ALA C 57 97 ARG D Protein A 3 FT #SUB 51 91 ASP C 56 96 PRO D Protein A 8 FT #SUB 52 92 GLY C 56 96 PRO D Protein B 6 FT #SUB 54 94 CYS C 54 94 CYS D Protein S 1 FT #SUB 54 94 CYS C 55 95 THR D Protein A 5 FT #SUB 54 94 CYS C 56 96 PRO D Protein B 5 FT #SUB 54 94 CYS C 59 99 CYS D Protein S 2 FT #SUB 55 95 THR C 54 94 CYS D Protein B 2 FT #SUB 56 96 PRO C 51 91 ASP D Protein A 4 FT #SUB 56 96 PRO C 52 92 GLY D Protein B 3 FT #SUB 56 96 PRO C 54 94 CYS D Protein A 5 FT #SUB 57 97 ARG C 45 85 SER D Protein S 2 FT #SUB 57 97 ARG C 46 86 ALA D Protein S 1 FT #SUB 57 97 ARG C 48 88 ALA D Protein S 5 FT #SUB 57 97 ARG C 49 89 GLN D Protein S 4 FT #SUB 57 97 ARG C 427 467 TYR D Protein B 2 FT #SUB 58 98 ARG C 29 69 PRO D Protein S 1 FT #SUB 58 98 ARG C 425 465 VAL D Protein S 2 FT #SUB 58 98 ARG C 426 466 ASN D Protein A 3 FT #SUB 58 98 ARG C 427 467 TYR D Protein S 1 FT #SUB 59 99 CYS C 54 94 CYS D Protein S 2 FT #SUB 59 99 CYS C 59 99 CYS D Protein S 1 FT #SUB 59 99 CYS C 425 465 VAL D Protein B 2 FT #SUB 59 99 CYS C 426 466 ASN D Protein A 5 FT #SUB 60 100 LEU C 29 69 PRO D Protein S 2 FT #SUB 60 100 LEU C 425 465 VAL D Protein S 2 FT #SUB 62 102 SER C 405 445 TRP D Protein S 3 FT #SUB 62 102 SER C 423 463 GLU D Protein A 3 FT #SUB 62 102 SER C 424 464 MET D Protein S 5 FT #SUB 63 103 LEU C 30 70 ARG D Protein S 1 FT #SUB 63 103 LEU C 423 463 GLU D Protein A 9 FT #SUB 64 104 VAL C 34 74 TRP D Protein S 6 FT #SUB 64 104 VAL C 423 463 GLU D Protein A 5 FT #SUB 65 105 PHE C 34 74 TRP D Protein S 3 FT #SUB 324 364 THR C 415 455 SER D Protein S 1 FT #SUB 325 365 ARG C 415 455 SER D Protein S 1 FT #SUB 325 365 ARG C 420 460 PHE D Protein S 3 FT #SUB 329 369 ASP C 421 461 HIS D Protein S 3 FT #SUB 330 370 PRO C 35 75 GLU D Protein S 5 FT #SUB 330 370 PRO C 421 461 HIS D Protein S 1 FT #SUB 331 371 HIS C 34 74 TRP D Protein S 5 FT #SUB 331 371 HIS C 35 75 GLU D Protein S 2 FT #SUB 331 371 HIS C 421 461 HIS D Protein S 1 FT #SUB 350 390 THR C 379 419 ASP D Protein A 7 FT #SUB 350 390 THR C 381 421 HIS D Protein A 3 FT #SUB 351 391 SER C 367 407 LEU D Protein B 1 FT #SUB 351 391 SER C 371 411 GLN D Protein S 2 FT #SUB 351 391 SER C 379 419 ASP D Protein A 3 FT #SUB 352 392 SER C 364 404 VAL D Protein B 1 FT #SUB 353 393 LEU C 360 400 VAL D Protein S 1 FT #SUB 353 393 LEU C 363 403 ASN D Protein S 1 FT #SUB 353 393 LEU C 364 404 VAL D Protein S 2 FT #SUB 353 393 LEU C 367 407 LEU D Protein S 2 FT #SUB 353 393 LEU C 380 420 HIS D Protein S 1 FT #SUB 353 393 LEU C 381 421 HIS D Protein S 1 FT #SUB 355 395 LYS C 381 421 HIS D Protein S 1 FT #SUB 355 395 LYS C 416 456 LEU D Protein B 2 FT #SUB 356 396 ASP C 360 400 VAL D Protein S 1 FT #SUB 356 396 ASP C 380 420 HIS D Protein S 4 FT #SUB 356 396 ASP C 381 421 HIS D Protein S 7 FT #SUB 356 396 ASP C 413 453 SER D Protein A 6 FT #SUB 356 396 ASP C 416 456 LEU D Protein B 1 FT #SUB 357 397 LYS C 360 400 VAL D Protein S 1 FT #SUB 357 397 LYS C 361 401 GLU D Protein S 1 FT #SUB 357 397 LYS C 364 404 VAL D Protein S 1 FT #SUB 359 399 ALA C 416 456 LEU D Protein S 1 FT #SUB 360 400 VAL C 353 393 LEU D Protein B 1 FT #SUB 360 400 VAL C 356 396 ASP D Protein S 1 FT #SUB 360 400 VAL C 357 397 LYS D Protein S 1 FT #SUB 361 401 GLU C 357 397 LYS D Protein S 1 FT #SUB 363 403 ASN C 353 393 LEU D Protein S 1 FT #SUB 364 404 VAL C 353 393 LEU D Protein A 2 FT #SUB 364 404 VAL C 357 397 LYS D Protein S 1 FT #SUB 367 407 LEU C 351 391 SER D Protein S 1 FT #SUB 367 407 LEU C 353 393 LEU D Protein S 1 FT #SUB 371 411 GLN C 351 391 SER D Protein S 2 FT #SUB 379 419 ASP C 350 390 THR D Protein S 7 FT #SUB 379 419 ASP C 351 391 SER D Protein S 3 FT #SUB 380 420 HIS C 353 393 LEU D Protein S 1 FT #SUB 380 420 HIS C 356 396 ASP D Protein S 3 FT #SUB 381 421 HIS C 350 390 THR D Protein S 2 FT #SUB 381 421 HIS C 353 393 LEU D Protein S 1 FT #SUB 381 421 HIS C 355 395 LYS D Protein S 1 FT #SUB 381 421 HIS C 356 396 ASP D Protein S 7 FT #SUB 405 445 TRP C 62 102 SER D Protein S 3 FT #SUB 405 445 TRP C 406 446 ALA D Protein S 3 FT #SUB 406 446 ALA C 405 445 TRP D Protein A 3 FT #SUB 411 451 PRO C 413 453 SER D Protein B 1 FT #SUB 411 451 PRO C 414 454 GLY D Protein B 3 FT #SUB 411 451 PRO C 415 455 SER D Protein A 6 FT #SUB 412 452 ILE C 356 396 ASP D Protein S 1 FT #SUB 413 453 SER C 356 396 ASP D Protein S 6 FT #SUB 413 453 SER C 411 451 PRO D Protein B 1 FT #SUB 413 453 SER C 413 453 SER D Protein B 1 FT #SUB 414 454 GLY C 411 451 PRO D Protein B 3 FT #SUB 415 455 SER C 324 364 THR D Protein S 1 FT #SUB 415 455 SER C 325 365 ARG D Protein S 3 FT #SUB 415 455 SER C 411 451 PRO D Protein A 6 FT #SUB 416 456 LEU C 336 376 LEU D Protein S 1 FT #SUB 416 456 LEU C 355 395 LYS D Protein S 2 FT #SUB 416 456 LEU C 356 396 ASP D Protein S 2 FT #SUB 416 456 LEU C 359 399 ALA D Protein S 1 FT #SUB 420 460 PHE C 325 365 ARG D Protein S 4 FT #SUB 421 461 HIS C 325 365 ARG D Protein S 1 FT #SUB 421 461 HIS C 329 369 ASP D Protein S 4 FT #SUB 421 461 HIS C 331 371 HIS D Protein S 2 FT #SUB 423 463 GLU C 62 102 SER D Protein A 3 FT #SUB 423 463 GLU C 63 103 LEU D Protein S 6 FT #SUB 423 463 GLU C 64 104 VAL D Protein S 5 FT #SUB 424 464 MET C 62 102 SER D Protein B 4 FT #SUB 424 464 MET C 63 103 LEU D Protein B 1 FT #SUB 425 465 VAL C 58 98 ARG D Protein S 2 FT #SUB 425 465 VAL C 59 99 CYS D Protein B 2 FT #SUB 425 465 VAL C 60 100 LEU D Protein S 2 FT #SUB 426 466 ASN C 58 98 ARG D Protein B 3 FT #SUB 426 466 ASN C 59 99 CYS D Protein A 6 FT #SUB 427 467 TYR C 57 97 ARG D Protein A 2 FT #SUB 427 467 TYR C 58 98 ARG D Protein S 1 FT #HET 54 94 CYS C 24 507 ZN C S 2 FT #HET 59 99 CYS C 24 507 ZN C A 3 FT #HET 62 102 SER C 19 502 H4B C B 5 FT #HET 64 104 VAL C 19 502 H4B C S 1 FT #HET 127 167 GLU C 25 508 GOL C S 15 FT #HET 138 178 TRP C 18 501 HEM C S 34 FT #HET 141 181 ALA C 18 501 HEM C S 3 FT #HET 142 182 PRO C 18 501 HEM C A 2 FT #HET 143 183 ARG C 18 501 HEM C A 16 FT #HET 144 184 CYS C 18 501 HEM C A 15 FT #HET 145 185 VAL C 18 501 HEM C S 2 FT #HET 146 186 GLY C 18 501 HEM C B 2 FT #HET 153 193 LEU C 18 501 HEM C S 2 FT #HET 186 226 SER C 18 501 HEM C S 2 FT #HET 207 247 GLN C 20 503 F2J C S 2 FT #HET 207 247 GLN C 26 509 CL C S 2 FT #HET 210 250 ARG C 26 509 CL C S 1 FT #HET 220 260 SER C 13 504 BTB B S 2 FT #HET 221 261 VAL C 13 504 BTB B B 2 FT #HET 258 298 GLU C 23 506 BTB C S 12 FT #HET 259 299 PRO C 23 506 BTB C S 1 FT #HET 294 334 PRO C 20 503 F2J C A 7 FT #HET 296 336 VAL C 20 503 F2J C S 7 FT #HET 299 339 MET C 18 501 HEM C S 1 FT #HET 313 353 PHE C 18 501 HEM C S 11 FT #HET 313 353 PHE C 20 503 F2J C A 5 FT #HET 314 354 SER C 18 501 HEM C B 1 FT #HET 314 354 SER C 20 503 F2J C B 2 FT #HET 315 355 GLY C 18 501 HEM C B 1 FT #HET 315 355 GLY C 20 503 F2J C B 2 FT #HET 316 356 TRP C 18 501 HEM C A 16 FT #HET 316 356 TRP C 20 503 F2J C B 2 FT #HET 317 357 TYR C 26 509 CL C S 3 FT #HET 321 361 GLU C 18 501 HEM C S 5 FT #HET 321 361 GLU C 20 503 F2J C S 11 FT #HET 325 365 ARG C 19 502 H4B C S 11 FT #HET 326 366 ASN C 26 509 CL C S 1 FT #HET 333 373 TYR C 13 504 BTB B B 1 FT #HET 334 374 ASN C 13 504 BTB B A 3 FT #HET 337 377 GLU C 22 505 BTB C S 5 FT #HET 338 378 ASP C 13 504 BTB B S 2 FT #HET 341 381 VAL C 21 504 BTB C B 1 FT #HET 342 382 CYS C 21 504 BTB C B 2 FT #HET 344 384 ASP C 21 504 BTB C S 9 FT #HET 344 384 ASP C 27 510 GD C S 2 FT #HET 347 387 THR C 22 505 BTB C B 1 FT #HET 348 388 ARG C 22 505 BTB C A 3 FT #HET 405 445 TRP C 29 502 H4B D S 3 FT #HET 406 446 ALA C 19 502 H4B C B 3 FT #HET 407 447 TRP C 18 501 HEM C S 4 FT #HET 407 447 TRP C 19 502 H4B C A 28 FT #HET 420 460 PHE C 29 502 H4B D A 14 FT #HET 421 461 HIS C 29 502 H4B D B 2 FT #HET 422 462 GLN C 29 502 H4B D B 2 FT #HET 423 463 GLU C 29 502 H4B D A 3 FT #HET 433 473 PHE C 18 501 HEM C S 5 FT #HET 435 475 TYR C 18 501 HEM C S 3 FT DISORDER 1 27 FT DISORDER 67 78 CC SEQUENCE 401 AA (ATOM); CC FPRVKNWEVG SITYDTLSAQ AQQDGPCTPR RCLGSLVFPA PEQLLSQARD FINQYYSSIK CC RSGSQAHEQR LQEVEAEVAA TGTYQLRESE LVFGAKQAWR NAPRCVGRIQ WGKLQVFDAR CC DCRSAQEMFT YICNHIKYAT NRGNLRSAIT VFPQRCPGRG DFRIWNSQLV RYAGYRQQDG CC SVRGDPANVE ITELCIQHGW TPGNGRFDVL PLLLQAPDEP PELFLLPPEL VLEVPLEHPT CC LEWFAALGLR WYALPAVSNM LLEIGGLEFP AAPFSGWYMS TEIGTRNLCD PHRYNILEDV CC AVCMDLDTRT TSSLWKDKAA VEINVAVLHS YQLAKVTIVD HHAATASFMK HLENEQKARG CC GCPADWAWIV PPISGSLTPV FHQEMVNYFL SPAFRYQPDP W CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES APASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQ CC ATOM ---------------------------FPRVKNWEVGSITYDTLSAQAQQ CC *********************** CC SEQRES DGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKR CC ATOM DGPCTPRRCLGSLVFP------------APEQLLSQARDFINQYYSSIKR CC **************** ********************** CC SEQRES SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ATOM SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ************************************************** CC SEQRES GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ATOM GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ************************************************** CC SEQRES FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ATOM FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ************************************************** CC SEQRES LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ATOM LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ************************************************** CC SEQRES LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ATOM LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ************************************************** CC SEQRES SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ATOM SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ************************************************** CC SEQRES CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC ATOM CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC **************************************** SQ SEQUENCE 440 AA; MW; CN; APASLLPPAP EHSPPSSPLT QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW // ID 6CIFD STANDARD; PRT; 440 AA. DT CONVERTED FROM PDB (SEQRES) 6CIF DE Nitric oxide synthase, endothelial OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.200 CC R-Factor 0.192 FT #SUB 29 69 PRO D 58 98 ARG C Protein S 1 FT #SUB 29 69 PRO D 60 100 LEU C Protein S 2 FT #SUB 30 70 ARG D 63 103 LEU C Protein B 1 FT #SUB 34 74 TRP D 64 104 VAL C Protein S 6 FT #SUB 34 74 TRP D 65 105 PHE C Protein S 3 FT #SUB 34 74 TRP D 331 371 HIS C Protein B 5 FT #SUB 35 75 GLU D 330 370 PRO C Protein S 5 FT #SUB 35 75 GLU D 331 371 HIS C Protein B 2 FT #SUB 45 85 SER D 57 97 ARG C Protein B 2 FT #SUB 46 86 ALA D 57 97 ARG C Protein B 1 FT #SUB 48 88 ALA D 57 97 ARG C Protein B 5 FT #SUB 49 89 GLN D 57 97 ARG C Protein S 4 FT #SUB 51 91 ASP D 56 96 PRO C Protein A 4 FT #SUB 52 92 GLY D 56 96 PRO C Protein B 3 FT #SUB 54 94 CYS D 54 94 CYS C Protein S 1 FT #SUB 54 94 CYS D 55 95 THR C Protein B 2 FT #SUB 54 94 CYS D 56 96 PRO C Protein B 5 FT #SUB 54 94 CYS D 59 99 CYS C Protein S 2 FT #SUB 55 95 THR D 54 94 CYS C Protein B 5 FT #SUB 56 96 PRO D 51 91 ASP C Protein A 8 FT #SUB 56 96 PRO D 52 92 GLY C Protein A 6 FT #SUB 56 96 PRO D 54 94 CYS C Protein A 5 FT #SUB 57 97 ARG D 45 85 SER C Protein S 1 FT #SUB 57 97 ARG D 46 86 ALA C Protein S 4 FT #SUB 57 97 ARG D 48 88 ALA C Protein A 3 FT #SUB 57 97 ARG D 427 467 TYR C Protein B 2 FT #SUB 58 98 ARG D 425 465 VAL C Protein S 2 FT #SUB 58 98 ARG D 426 466 ASN C Protein A 3 FT #SUB 58 98 ARG D 427 467 TYR C Protein S 1 FT #SUB 59 99 CYS D 54 94 CYS C Protein S 2 FT #SUB 59 99 CYS D 59 99 CYS C Protein S 1 FT #SUB 59 99 CYS D 425 465 VAL C Protein B 2 FT #SUB 59 99 CYS D 426 466 ASN C Protein A 6 FT #SUB 60 100 LEU D 29 69 PRO C Protein S 1 FT #SUB 60 100 LEU D 425 465 VAL C Protein S 2 FT #SUB 62 102 SER D 405 445 TRP C Protein S 3 FT #SUB 62 102 SER D 423 463 GLU C Protein A 3 FT #SUB 62 102 SER D 424 464 MET C Protein S 4 FT #SUB 63 103 LEU D 30 70 ARG C Protein S 1 FT #SUB 63 103 LEU D 423 463 GLU C Protein A 6 FT #SUB 63 103 LEU D 424 464 MET C Protein S 1 FT #SUB 64 104 VAL D 34 74 TRP C Protein S 6 FT #SUB 64 104 VAL D 423 463 GLU C Protein A 5 FT #SUB 65 105 PHE D 34 74 TRP C Protein S 2 FT #SUB 68 108 LYS D 30 70 ARG C Protein S 5 FT #SUB 324 364 THR D 415 455 SER C Protein S 1 FT #SUB 325 365 ARG D 415 455 SER C Protein S 3 FT #SUB 325 365 ARG D 420 460 PHE C Protein S 4 FT #SUB 325 365 ARG D 421 461 HIS C Protein S 1 FT #SUB 329 369 ASP D 421 461 HIS C Protein S 4 FT #SUB 330 370 PRO D 35 75 GLU C Protein S 4 FT #SUB 331 371 HIS D 34 74 TRP C Protein S 5 FT #SUB 331 371 HIS D 35 75 GLU C Protein S 2 FT #SUB 331 371 HIS D 421 461 HIS C Protein S 2 FT #SUB 336 376 LEU D 416 456 LEU C Protein S 1 FT #SUB 350 390 THR D 379 419 ASP C Protein A 7 FT #SUB 350 390 THR D 381 421 HIS C Protein A 2 FT #SUB 351 391 SER D 367 407 LEU C Protein B 1 FT #SUB 351 391 SER D 371 411 GLN C Protein S 2 FT #SUB 351 391 SER D 379 419 ASP C Protein A 3 FT #SUB 353 393 LEU D 360 400 VAL C Protein S 1 FT #SUB 353 393 LEU D 363 403 ASN C Protein S 1 FT #SUB 353 393 LEU D 364 404 VAL C Protein S 2 FT #SUB 353 393 LEU D 367 407 LEU C Protein S 1 FT #SUB 353 393 LEU D 380 420 HIS C Protein S 1 FT #SUB 353 393 LEU D 381 421 HIS C Protein S 1 FT #SUB 355 395 LYS D 381 421 HIS C Protein S 1 FT #SUB 355 395 LYS D 416 456 LEU C Protein B 2 FT #SUB 356 396 ASP D 360 400 VAL C Protein S 1 FT #SUB 356 396 ASP D 380 420 HIS C Protein S 3 FT #SUB 356 396 ASP D 381 421 HIS C Protein S 7 FT #SUB 356 396 ASP D 412 452 ILE C Protein S 1 FT #SUB 356 396 ASP D 413 453 SER C Protein A 6 FT #SUB 356 396 ASP D 416 456 LEU C Protein B 2 FT #SUB 357 397 LYS D 360 400 VAL C Protein S 1 FT #SUB 357 397 LYS D 361 401 GLU C Protein S 1 FT #SUB 357 397 LYS D 364 404 VAL C Protein S 1 FT #SUB 359 399 ALA D 416 456 LEU C Protein S 1 FT #SUB 360 400 VAL D 353 393 LEU C Protein B 1 FT #SUB 360 400 VAL D 356 396 ASP C Protein S 1 FT #SUB 360 400 VAL D 357 397 LYS C Protein S 1 FT #SUB 361 401 GLU D 357 397 LYS C Protein S 1 FT #SUB 363 403 ASN D 353 393 LEU C Protein S 1 FT #SUB 364 404 VAL D 352 392 SER C Protein S 1 FT #SUB 364 404 VAL D 353 393 LEU C Protein A 2 FT #SUB 364 404 VAL D 357 397 LYS C Protein S 1 FT #SUB 367 407 LEU D 351 391 SER C Protein S 1 FT #SUB 367 407 LEU D 353 393 LEU C Protein S 2 FT #SUB 371 411 GLN D 351 391 SER C Protein S 2 FT #SUB 379 419 ASP D 350 390 THR C Protein S 7 FT #SUB 379 419 ASP D 351 391 SER C Protein S 3 FT #SUB 380 420 HIS D 353 393 LEU C Protein S 1 FT #SUB 380 420 HIS D 356 396 ASP C Protein S 4 FT #SUB 381 421 HIS D 350 390 THR C Protein S 3 FT #SUB 381 421 HIS D 353 393 LEU C Protein S 1 FT #SUB 381 421 HIS D 355 395 LYS C Protein S 1 FT #SUB 381 421 HIS D 356 396 ASP C Protein S 7 FT #SUB 405 445 TRP D 62 102 SER C Protein S 3 FT #SUB 405 445 TRP D 406 446 ALA C Protein S 3 FT #SUB 406 446 ALA D 405 445 TRP C Protein A 3 FT #SUB 411 451 PRO D 413 453 SER C Protein B 1 FT #SUB 411 451 PRO D 414 454 GLY C Protein B 3 FT #SUB 411 451 PRO D 415 455 SER C Protein A 6 FT #SUB 413 453 SER D 356 396 ASP C Protein S 6 FT #SUB 413 453 SER D 411 451 PRO C Protein B 1 FT #SUB 413 453 SER D 413 453 SER C Protein B 1 FT #SUB 414 454 GLY D 411 451 PRO C Protein B 3 FT #SUB 415 455 SER D 324 364 THR C Protein S 1 FT #SUB 415 455 SER D 325 365 ARG C Protein S 1 FT #SUB 415 455 SER D 411 451 PRO C Protein A 6 FT #SUB 416 456 LEU D 355 395 LYS C Protein S 2 FT #SUB 416 456 LEU D 356 396 ASP C Protein S 1 FT #SUB 416 456 LEU D 359 399 ALA C Protein S 1 FT #SUB 420 460 PHE D 325 365 ARG C Protein S 3 FT #SUB 421 461 HIS D 329 369 ASP C Protein S 3 FT #SUB 421 461 HIS D 330 370 PRO C Protein S 1 FT #SUB 421 461 HIS D 331 371 HIS C Protein S 1 FT #SUB 423 463 GLU D 62 102 SER C Protein A 3 FT #SUB 423 463 GLU D 63 103 LEU C Protein S 9 FT #SUB 423 463 GLU D 64 104 VAL C Protein S 5 FT #SUB 424 464 MET D 62 102 SER C Protein A 5 FT #SUB 425 465 VAL D 58 98 ARG C Protein S 2 FT #SUB 425 465 VAL D 59 99 CYS C Protein B 2 FT #SUB 425 465 VAL D 60 100 LEU C Protein S 2 FT #SUB 426 466 ASN D 58 98 ARG C Protein B 3 FT #SUB 426 466 ASN D 59 99 CYS C Protein B 5 FT #SUB 427 467 TYR D 57 97 ARG C Protein A 2 FT #SUB 427 467 TYR D 58 98 ARG C Protein S 1 FT #HET 34 74 TRP D 19 502 H4B C S 1 FT #HET 54 94 CYS D 24 507 ZN C S 2 FT #HET 59 99 CYS D 24 507 ZN C A 3 FT #HET 62 102 SER D 29 502 H4B D B 4 FT #HET 64 104 VAL D 29 502 H4B D S 1 FT #HET 138 178 TRP D 28 501 HEM D S 32 FT #HET 141 181 ALA D 28 501 HEM D S 2 FT #HET 143 183 ARG D 28 501 HEM D A 11 FT #HET 144 184 CYS D 28 501 HEM D A 16 FT #HET 145 185 VAL D 28 501 HEM D S 2 FT #HET 146 186 GLY D 28 501 HEM D B 5 FT #HET 153 193 LEU D 28 501 HEM D S 1 FT #HET 186 226 SER D 28 501 HEM D S 2 FT #HET 207 247 GLN D 30 503 F2J D S 1 FT #HET 207 247 GLN D 35 508 CL D S 1 FT #HET 258 298 GLU D 32 505 BTB D S 20 FT #HET 279 319 THR D 31 504 BTB D A 5 FT #HET 279 319 THR D 34 507 GD D B 2 FT #HET 281 321 GLU D 31 504 BTB D S 10 FT #HET 281 321 GLU D 34 507 GD D S 3 FT #HET 294 334 PRO D 30 503 F2J D A 9 FT #HET 296 336 VAL D 30 503 F2J D S 7 FT #HET 313 353 PHE D 28 501 HEM D S 14 FT #HET 313 353 PHE D 30 503 F2J D A 5 FT #HET 314 354 SER D 28 501 HEM D B 1 FT #HET 314 354 SER D 30 503 F2J D B 2 FT #HET 315 355 GLY D 30 503 F2J D B 2 FT #HET 316 356 TRP D 28 501 HEM D A 16 FT #HET 316 356 TRP D 30 503 F2J D B 1 FT #HET 317 357 TYR D 35 508 CL D S 3 FT #HET 321 361 GLU D 28 501 HEM D S 4 FT #HET 321 361 GLU D 30 503 F2J D S 11 FT #HET 325 365 ARG D 29 502 H4B D S 7 FT #HET 326 366 ASN D 35 508 CL D S 1 FT #HET 337 377 GLU D 33 506 BTB D S 7 FT #HET 338 378 ASP D 33 506 BTB D S 18 FT #HET 405 445 TRP D 19 502 H4B C S 3 FT #HET 406 446 ALA D 29 502 H4B D B 4 FT #HET 407 447 TRP D 28 501 HEM D S 1 FT #HET 407 447 TRP D 29 502 H4B D A 36 FT #HET 420 460 PHE D 19 502 H4B C A 13 FT #HET 421 461 HIS D 19 502 H4B C B 3 FT #HET 422 462 GLN D 19 502 H4B C B 2 FT #HET 423 463 GLU D 19 502 H4B C A 3 FT #HET 433 473 PHE D 28 501 HEM D S 7 FT #HET 435 475 TYR D 28 501 HEM D S 9 FT DISORDER 1 26 FT DISORDER 69 78 CC SEQUENCE 404 AA (ATOM); CC KFPRVKNWEV GSITYDTLSA QAQQDGPCTP RRCLGSLVFP RKAPEQLLSQ ARDFINQYYS CC SIKRSGSQAH EQRLQEVEAE VAATGTYQLR ESELVFGAKQ AWRNAPRCVG RIQWGKLQVF CC DARDCRSAQE MFTYICNHIK YATNRGNLRS AITVFPQRCP GRGDFRIWNS QLVRYAGYRQ CC QDGSVRGDPA NVEITELCIQ HGWTPGNGRF DVLPLLLQAP DEPPELFLLP PELVLEVPLE CC HPTLEWFAAL GLRWYALPAV SNMLLEIGGL EFPAAPFSGW YMSTEIGTRN LCDPHRYNIL CC EDVAVCMDLD TRTTSSLWKD KAAVEINVAV LHSYQLAKVT IVDHHAATAS FMKHLENEQK CC ARGGCPADWA WIVPPISGSL TPVFHQEMVN YFLSPAFRYQ PDPW CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES APASLLPPAPEHSPPSSPLTQPPEGPKFPRVKNWEVGSITYDTLSAQAQQ CC ATOM --------------------------KFPRVKNWEVGSITYDTLSAQAQQ CC ************************ CC SEQRES DGPCTPRRCLGSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKR CC ATOM DGPCTPRRCLGSLVFPRK----------APEQLLSQARDFINQYYSSIKR CC ****************** ********************** CC SEQRES SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ATOM SGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQW CC ************************************************** CC SEQRES GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ATOM GKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGD CC ************************************************** CC SEQRES FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ATOM FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLP CC ************************************************** CC SEQRES LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ATOM LLLQAPDEPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML CC ************************************************** CC SEQRES LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ATOM LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTT CC ************************************************** CC SEQRES SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ATOM SSLWKDKAAVEINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGG CC ************************************************** CC SEQRES CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC ATOM CPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPW CC **************************************** SQ SEQUENCE 440 AA; MW; CN; APASLLPPAP EHSPPSSPLT QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW //