ID 6AZKA STANDARD; PRT; 213 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE cetuximab Fab light chain OS Mus musculus, Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 34 34 HIS A 105 105 GLU B Protein S 6 FT #SUB 36 36 TYR A 105 105 GLU B Protein S 2 FT #SUB 36 36 TYR A 106 106 PHE B Protein S 7 FT #SUB 36 36 TYR A 109 109 TRP B Protein S 2 FT #SUB 38 38 GLN A 39 39 GLN B Protein S 8 FT #SUB 38 38 GLN A 94 94 TYR B Protein S 1 FT #SUB 43 43 SER A 94 94 TYR B Protein S 2 FT #SUB 43 43 SER A 109 109 TRP B Protein S 1 FT #SUB 43 43 SER A 110 110 GLY B Protein S 3 FT #SUB 43 43 SER A 111 111 GLN B Protein S 3 FT #SUB 44 44 PRO A 94 94 TYR B Protein S 2 FT #SUB 44 44 PRO A 109 109 TRP B Protein A 10 FT #SUB 46 46 LEU A 106 106 PHE B Protein S 1 FT #SUB 46 46 LEU A 107 107 ALA B Protein S 3 FT #SUB 49 49 LYS A 99 99 LEU B Protein S 2 FT #SUB 50 50 TYR A 103 103 ASP B Protein S 5 FT #SUB 50 50 TYR A 105 105 GLU B Protein S 1 FT #SUB 87 87 TYR A 39 39 GLN B Protein S 2 FT #SUB 87 87 TYR A 45 45 LEU B Protein S 1 FT #SUB 89 89 GLN A 104 104 TYR B Protein S 3 FT #SUB 89 89 GLN A 106 106 PHE B Protein S 2 FT #SUB 91 91 ASN A 104 104 TYR B Protein S 6 FT #SUB 94 94 TRP A 47 47 TRP B Protein S 4 FT #SUB 94 94 TRP A 59 59 TYR B Protein S 2 FT #SUB 94 94 TRP A 61 61 THR B Protein S 3 FT #SUB 95 95 PRO A 47 47 TRP B Protein S 1 FT #SUB 95 95 PRO A 60 60 ASN B Protein S 6 FT #SUB 96 96 THR A 47 47 TRP B Protein A 5 FT #SUB 98 98 PHE A 45 45 LEU B Protein S 7 FT #SUB 116 116 PHE A 135 135 LYS B Protein A 3 FT #SUB 116 116 PHE A 136 136 SER B Protein S 7 FT #SUB 116 116 PHE A 137 137 THR B Protein S 1 FT #SUB 116 116 PHE A 143 143 ALA B Protein S 2 FT #SUB 117 117 ILE A 135 135 LYS B Protein A 3 FT #SUB 118 118 PHE A 130 130 LEU B Protein S 7 FT #SUB 118 118 PHE A 131 131 ALA B Protein S 2 FT #SUB 118 118 PHE A 136 136 SER B Protein S 3 FT #SUB 118 118 PHE A 143 143 ALA B Protein S 3 FT #SUB 121 121 SER A 128 128 PHE B Protein S 2 FT #SUB 121 121 SER A 129 129 PRO B Protein S 4 FT #SUB 123 123 GLU A 129 129 PRO B Protein S 2 FT #SUB 124 124 GLN A 128 128 PHE B Protein A 14 FT #SUB 124 124 GLN A 147 147 LEU B Protein S 1 FT #SUB 124 124 GLN A 149 149 LYS B Protein S 2 FT #SUB 131 131 SER A 147 147 LEU B Protein S 2 FT #SUB 131 131 SER A 149 149 LYS B Protein S 1 FT #SUB 133 133 VAL A 130 130 LEU B Protein S 1 FT #SUB 135 135 LEU A 172 172 PHE B Protein S 2 FT #SUB 137 137 ASN A 170 170 HIS B Protein S 2 FT #SUB 137 137 ASN A 189 189 THR B Protein S 1 FT #SUB 138 138 ASN A 170 170 HIS B Protein S 4 FT #SUB 160 160 GLN A 175 175 VAL B Protein S 2 FT #SUB 160 160 GLN A 176 176 LEU B Protein S 1 FT #SUB 160 160 GLN A 177 177 GLN B Protein S 1 FT #SUB 161 161 GLU A 175 175 VAL B Protein B 1 FT #SUB 162 162 SER A 172 172 PHE B Protein A 6 FT #SUB 162 162 SER A 173 173 PRO B Protein S 8 FT #SUB 162 162 SER A 175 175 VAL B Protein S 1 FT #SUB 163 163 VAL A 173 173 PRO B Protein B 3 FT #SUB 164 164 THR A 172 172 PHE B Protein A 3 FT #SUB 167 167 ASP A 170 170 HIS B Protein S 1 FT #SUB 174 174 SER A 170 170 HIS B Protein S 4 FT #SUB 174 174 SER A 172 172 PHE B Protein B 4 FT #SUB 175 175 LEU A 172 172 PHE B Protein B 6 FT #SUB 176 176 SER A 172 172 PHE B Protein A 7 FT #SUB 208 208 SER A 135 135 LYS B Protein B 5 FT #SUB 209 209 PHE A 135 135 LYS B Protein S 1 FT #SUB 8 8 PRO A 11 11 LEU C Protein S 3 FT #SUB 11 11 LEU A 8 8 PRO C Protein S 1 FT #SUB 20 20 SER A 7 7 SER C Protein S 1 FT #SUB 24 24 ARG A 20 20 SER C Protein S 2 FT #SUB 24 24 ARG A 21 21 PHE C Protein S 1 FT #SUB 24 24 ARG A 22 22 SER C Protein S 1 FT #SUB 24 24 ARG A 72 72 THR C Protein S 8 FT #SUB 66 66 GLY A 70 70 ASP C Protein B 1 FT #SUB 70 70 ASP A 70 70 ASP C Protein S 1 FT #SUB 70 70 ASP A 72 72 THR C Protein S 1 FT #SUB 143 143 GLU A 199 199 GLN C Protein S 3 FT #SUB 145 145 LYS A 199 199 GLN C Protein S 3 FT #SUB 145 145 LYS A 201 201 LEU C Protein S 1 FT #SUB 199 199 GLN A 143 143 GLU C Protein S 7 FT #SUB 199 199 GLN A 145 145 LYS C Protein B 2 FT #SUB 201 201 LEU A 145 145 LYS C Protein B 3 FT #SUB 202 202 SER A 147 147 GLN C Protein B 5 FT #SUB 9 9 VAL A 11 1 011 E Protein S 3 FT #SUB 10 10 ILE A 11 1 011 E Protein S 1 FT #SUB 38 38 GLN A 2 3 PHE E Protein S 1 FT #SUB 38 38 GLN A 7 8 C6D E Protein S 5 FT #SUB 38 38 GLN A 8 9 ARG E Protein B 2 FT #SUB 39 39 ARG A 8 9 ARG E Protein B 2 FT #SUB 40 40 THR A 6 7 THR E Protein A 3 FT #SUB 40 40 THR A 8 9 ARG E Protein A 6 FT #SUB 41 41 ASN A 5 6 SER E Protein S 1 FT #SUB 41 41 ASN A 6 7 THR E Protein A 6 FT #SUB 41 41 ASN A 7 8 C6D E Protein B 1 FT #SUB 42 42 GLY A 7 8 C6D E Protein B 3 FT #SUB 43 43 SER A 7 8 C6D E Protein A 2 FT #SUB 84 84 ALA A 8 9 ARG E Protein B 6 FT #SUB 85 85 ASP A 8 9 ARG E Protein A 14 FT #SUB 85 85 ASP A 9 10 LEU E Protein S 8 FT #SUB 87 87 TYR A 9 10 LEU E Protein S 3 FT #SUB 100 100 ALA A 9 10 LEU E Protein B 2 FT #SUB 101 101 GLY A 9 10 LEU E Protein B 2 FT #SUB 103 103 LYS A 8 9 ARG E Protein S 2 FT #SUB 103 103 LYS A 9 10 LEU E Protein S 3 FT #SUB 165 165 GLU A 6 7 THR E Protein S 1 FT #SUB 165 165 GLU A 8 9 ARG E Protein S 3 FT DISORDER 213 213 CC SEQUENCE 212 AA (ATOM); CC DILLTQSPVI LSVSPGERVS FSCRASQSIG TNIHWYQQRT NGSPRLLIKY ASESISGIPS CC RFSGSGSGTD FTLSINSVES EDIADYYCQQ NNNWPTTFGA GTKLELKRTV AAPSVFIFPP CC SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT CC LSKADYEKHK VYACEVTHQG LSSPVTKSFN RG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKY CC ATOM DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKY CC ************************************************** CC SEQRES ASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGA CC ATOM ASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGA CC ************************************************** CC SEQRES GTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV CC ATOM GTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV CC ************************************************** CC SEQRES DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG CC ATOM DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG CC ************************************************** CC SEQRES LSSPVTKSFNRGA CC ATOM LSSPVTKSFNRG- CC ************ SQ SEQUENCE 213 AA; MW; CN; DILLTQSPVI LSVSPGERVS FSCRASQSIG TNIHWYQQRT NGSPRLLIKY ASESISGIPS RFSGSGSGTD FTLSINSVES EDIADYYCQQ NNNWPTTFGA GTKLELKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGA // ID 6AZKB STANDARD; PRT; 221 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE cetuximab Fab heavy chain OS Mus musculus, Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 39 39 GLN B 38 38 GLN A Protein S 8 FT #SUB 39 39 GLN B 87 87 TYR A Protein S 2 FT #SUB 45 45 LEU B 87 87 TYR A Protein S 1 FT #SUB 45 45 LEU B 98 98 PHE A Protein A 7 FT #SUB 47 47 TRP B 94 94 TRP A Protein S 4 FT #SUB 47 47 TRP B 95 95 PRO A Protein S 1 FT #SUB 47 47 TRP B 96 96 THR A Protein S 5 FT #SUB 59 59 TYR B 94 94 TRP A Protein B 2 FT #SUB 60 60 ASN B 95 95 PRO A Protein S 6 FT #SUB 61 61 THR B 94 94 TRP A Protein A 3 FT #SUB 94 94 TYR B 38 38 GLN A Protein S 1 FT #SUB 94 94 TYR B 43 43 SER A Protein S 2 FT #SUB 94 94 TYR B 44 44 PRO A Protein S 2 FT #SUB 99 99 LEU B 49 49 LYS A Protein S 2 FT #SUB 103 103 ASP B 50 50 TYR A Protein S 5 FT #SUB 104 104 TYR B 89 89 GLN A Protein B 3 FT #SUB 104 104 TYR B 91 91 ASN A Protein S 6 FT #SUB 105 105 GLU B 34 34 HIS A Protein A 6 FT #SUB 105 105 GLU B 36 36 TYR A Protein B 2 FT #SUB 105 105 GLU B 50 50 TYR A Protein S 1 FT #SUB 106 106 PHE B 36 36 TYR A Protein A 7 FT #SUB 106 106 PHE B 46 46 LEU A Protein B 1 FT #SUB 106 106 PHE B 89 89 GLN A Protein S 2 FT #SUB 107 107 ALA B 46 46 LEU A Protein A 3 FT #SUB 109 109 TRP B 36 36 TYR A Protein S 2 FT #SUB 109 109 TRP B 43 43 SER A Protein S 1 FT #SUB 109 109 TRP B 44 44 PRO A Protein S 10 FT #SUB 110 110 GLY B 43 43 SER A Protein B 3 FT #SUB 111 111 GLN B 43 43 SER A Protein B 3 FT #SUB 128 128 PHE B 121 121 SER A Protein S 2 FT #SUB 128 128 PHE B 124 124 GLN A Protein S 14 FT #SUB 129 129 PRO B 121 121 SER A Protein A 4 FT #SUB 129 129 PRO B 123 123 GLU A Protein S 2 FT #SUB 130 130 LEU B 118 118 PHE A Protein A 7 FT #SUB 130 130 LEU B 133 133 VAL A Protein S 1 FT #SUB 131 131 ALA B 118 118 PHE A Protein B 2 FT #SUB 135 135 LYS B 116 116 PHE A Protein B 3 FT #SUB 135 135 LYS B 117 117 ILE A Protein A 3 FT #SUB 135 135 LYS B 208 208 SER A Protein S 5 FT #SUB 135 135 LYS B 209 209 PHE A Protein S 1 FT #SUB 136 136 SER B 116 116 PHE A Protein A 7 FT #SUB 136 136 SER B 118 118 PHE A Protein S 3 FT #SUB 137 137 THR B 116 116 PHE A Protein B 1 FT #SUB 143 143 ALA B 116 116 PHE A Protein S 2 FT #SUB 143 143 ALA B 118 118 PHE A Protein B 3 FT #SUB 147 147 LEU B 124 124 GLN A Protein S 1 FT #SUB 147 147 LEU B 131 131 SER A Protein S 2 FT #SUB 149 149 LYS B 124 124 GLN A Protein S 2 FT #SUB 149 149 LYS B 131 131 SER A Protein S 1 FT #SUB 170 170 HIS B 137 137 ASN A Protein S 2 FT #SUB 170 170 HIS B 138 138 ASN A Protein S 4 FT #SUB 170 170 HIS B 167 167 ASP A Protein S 1 FT #SUB 170 170 HIS B 174 174 SER A Protein S 4 FT #SUB 172 172 PHE B 135 135 LEU A Protein S 2 FT #SUB 172 172 PHE B 162 162 SER A Protein A 6 FT #SUB 172 172 PHE B 164 164 THR A Protein S 3 FT #SUB 172 172 PHE B 174 174 SER A Protein S 4 FT #SUB 172 172 PHE B 175 175 LEU A Protein S 6 FT #SUB 172 172 PHE B 176 176 SER A Protein S 7 FT #SUB 173 173 PRO B 162 162 SER A Protein A 8 FT #SUB 173 173 PRO B 163 163 VAL A Protein S 3 FT #SUB 175 175 VAL B 160 160 GLN A Protein S 2 FT #SUB 175 175 VAL B 161 161 GLU A Protein S 1 FT #SUB 175 175 VAL B 162 162 SER A Protein S 1 FT #SUB 176 176 LEU B 160 160 GLN A Protein B 1 FT #SUB 177 177 GLN B 160 160 GLN A Protein S 1 FT #SUB 189 189 THR B 137 137 ASN A Protein S 1 FT #SUB 9 9 PRO B 7 8 C6D E Protein S 3 FT #SUB 39 39 GLN B 2 3 PHE E Protein A 15 FT #SUB 39 39 GLN B 4 5 LEU E Protein B 1 FT #SUB 40 40 SER B 2 3 PHE E Protein B 2 FT #SUB 41 41 PRO B 1 2 GLN E Protein A 3 FT #SUB 41 41 PRO B 2 3 PHE E Protein A 3 FT #SUB 41 41 PRO B 4 5 LEU E Protein S 3 FT #SUB 90 90 THR B 4 5 LEU E Protein S 1 FT #SUB 91 91 ALA B 4 5 LEU E Protein B 2 FT #SUB 92 92 ILE B 2 3 PHE E Protein S 2 FT #SUB 92 92 ILE B 4 5 LEU E Protein A 2 FT #SUB 92 92 ILE B 7 8 C6D E Protein S 3 FT #SUB 94 94 TYR B 7 8 C6D E Protein S 3 FT #SUB 111 111 GLN B 7 8 C6D E Protein B 6 FT #SUB 112 112 GLY B 7 8 C6D E Protein B 5 FT #SUB 113 113 THR B 7 8 C6D E Protein B 2 FT #SUB 114 114 LEU B 4 5 LEU E Protein S 2 FT #SUB 114 114 LEU B 7 8 C6D E Protein A 5 FT #SUB 154 154 GLU B 5 6 SER E Protein S 4 FT #SUB 155 155 PRO B 7 8 C6D E Protein S 1 FT #SUB 173 173 PRO B 6 7 THR E Protein S 2 FT #HET 10 10 GLY B 1 301 SO4 B B 4 FT #HET 12 12 VAL B 1 301 SO4 B S 1 FT #HET 18 18 LEU B 1 301 SO4 B S 3 FT #HET 19 19 SER B 1 301 SO4 B B 5 FT #HET 20 20 ILE B 1 301 SO4 B S 1 FT DISORDER 220 221 CC SEQUENCE 219 AA (ATOM); CC QVQLKQSGPG LVQPSQSLSI TCTVSGFSLT NYGVHWVRQS PGKGLEWLGV IWSGGNTDYN CC TPFTSRLSIN KDNSKSQVFF KMNSLQSNDT AIYYCARALT YYDYEFAYWG QGTLVTVSAA CC STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG CC LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGV CC ATOM QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGV CC ************************************************** CC SEQRES IWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALT CC ATOM IWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALT CC ************************************************** CC SEQRES YYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKD CC ATOM YYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKD CC ************************************************** CC SEQRES YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY CC ATOM YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY CC ************************************************** CC SEQRES ICNVNHKPSNTKVDKRVEPKS CC ATOM ICNVNHKPSNTKVDKRVEP-- CC ******************* SQ SEQUENCE 221 AA; MW; CN; QVQLKQSGPG LVQPSQSLSI TCTVSGFSLT NYGVHWVRQS PGKGLEWLGV IWSGGNTDYN TPFTSRLSIN KDNSKSQVFF KMNSLQSNDT AIYYCARALT YYDYEFAYWG QGTLVTVSAA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK S // ID 6AZKC STANDARD; PRT; 213 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE cetuximab Fab light chain OS Mus musculus, Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 7 7 SER C 20 20 SER A Protein S 1 FT #SUB 8 8 PRO C 11 11 LEU A Protein S 1 FT #SUB 11 11 LEU C 8 8 PRO A Protein S 3 FT #SUB 20 20 SER C 24 24 ARG A Protein S 2 FT #SUB 21 21 PHE C 24 24 ARG A Protein B 1 FT #SUB 22 22 SER C 24 24 ARG A Protein S 1 FT #SUB 70 70 ASP C 66 66 GLY A Protein S 1 FT #SUB 70 70 ASP C 70 70 ASP A Protein S 1 FT #SUB 72 72 THR C 24 24 ARG A Protein S 8 FT #SUB 72 72 THR C 70 70 ASP A Protein S 1 FT #SUB 143 143 GLU C 199 199 GLN A Protein S 7 FT #SUB 145 145 LYS C 199 199 GLN A Protein S 2 FT #SUB 145 145 LYS C 201 201 LEU A Protein S 3 FT #SUB 147 147 GLN C 202 202 SER A Protein S 5 FT #SUB 199 199 GLN C 143 143 GLU A Protein A 3 FT #SUB 199 199 GLN C 145 145 LYS A Protein B 3 FT #SUB 201 201 LEU C 145 145 LYS A Protein B 1 FT #SUB 34 34 HIS C 105 105 GLU D Protein S 5 FT #SUB 36 36 TYR C 105 105 GLU D Protein S 1 FT #SUB 36 36 TYR C 106 106 PHE D Protein S 6 FT #SUB 36 36 TYR C 109 109 TRP D Protein S 1 FT #SUB 38 38 GLN C 39 39 GLN D Protein S 7 FT #SUB 38 38 GLN C 94 94 TYR D Protein S 1 FT #SUB 43 43 SER C 94 94 TYR D Protein A 4 FT #SUB 43 43 SER C 109 109 TRP D Protein S 1 FT #SUB 43 43 SER C 110 110 GLY D Protein S 3 FT #SUB 43 43 SER C 111 111 GLN D Protein S 3 FT #SUB 44 44 PRO C 94 94 TYR D Protein S 2 FT #SUB 44 44 PRO C 109 109 TRP D Protein A 13 FT #SUB 46 46 LEU C 106 106 PHE D Protein S 1 FT #SUB 46 46 LEU C 107 107 ALA D Protein S 3 FT #SUB 49 49 LYS C 99 99 LEU D Protein S 2 FT #SUB 50 50 TYR C 103 103 ASP D Protein S 5 FT #SUB 50 50 TYR C 105 105 GLU D Protein S 1 FT #SUB 87 87 TYR C 39 39 GLN D Protein S 3 FT #SUB 87 87 TYR C 45 45 LEU D Protein S 3 FT #SUB 89 89 GLN C 104 104 TYR D Protein S 3 FT #SUB 89 89 GLN C 106 106 PHE D Protein S 2 FT #SUB 91 91 ASN C 103 103 ASP D Protein S 1 FT #SUB 91 91 ASN C 104 104 TYR D Protein S 8 FT #SUB 94 94 TRP C 47 47 TRP D Protein S 4 FT #SUB 94 94 TRP C 59 59 TYR D Protein S 2 FT #SUB 94 94 TRP C 61 61 THR D Protein S 3 FT #SUB 95 95 PRO C 47 47 TRP D Protein S 1 FT #SUB 95 95 PRO C 60 60 ASN D Protein S 5 FT #SUB 96 96 THR C 47 47 TRP D Protein A 5 FT #SUB 98 98 PHE C 45 45 LEU D Protein S 6 FT #SUB 116 116 PHE C 135 135 LYS D Protein B 2 FT #SUB 116 116 PHE C 136 136 SER D Protein S 6 FT #SUB 116 116 PHE C 143 143 ALA D Protein S 3 FT #SUB 117 117 ILE C 135 135 LYS D Protein A 5 FT #SUB 118 118 PHE C 130 130 LEU D Protein S 5 FT #SUB 118 118 PHE C 131 131 ALA D Protein S 4 FT #SUB 118 118 PHE C 136 136 SER D Protein S 3 FT #SUB 118 118 PHE C 143 143 ALA D Protein S 5 FT #SUB 121 121 SER C 128 128 PHE D Protein S 2 FT #SUB 121 121 SER C 129 129 PRO D Protein S 3 FT #SUB 122 122 ASP C 220 220 LYS D Protein S 4 FT #SUB 123 123 GLU C 129 129 PRO D Protein S 2 FT #SUB 123 123 GLU C 215 215 LYS D Protein S 1 FT #SUB 124 124 GLN C 128 128 PHE D Protein A 14 FT #SUB 124 124 GLN C 149 149 LYS D Protein S 2 FT #SUB 131 131 SER C 147 147 LEU D Protein S 2 FT #SUB 131 131 SER C 149 149 LYS D Protein S 2 FT #SUB 133 133 VAL C 130 130 LEU D Protein S 1 FT #SUB 135 135 LEU C 172 172 PHE D Protein S 2 FT #SUB 135 135 LEU C 187 187 VAL D Protein S 1 FT #SUB 137 137 ASN C 170 170 HIS D Protein S 2 FT #SUB 137 137 ASN C 189 189 THR D Protein S 1 FT #SUB 138 138 ASN C 170 170 HIS D Protein S 2 FT #SUB 160 160 GLN C 175 175 VAL D Protein S 2 FT #SUB 160 160 GLN C 176 176 LEU D Protein S 3 FT #SUB 160 160 GLN C 177 177 GLN D Protein S 2 FT #SUB 161 161 GLU C 175 175 VAL D Protein B 1 FT #SUB 162 162 SER C 172 172 PHE D Protein A 3 FT #SUB 162 162 SER C 173 173 PRO D Protein S 8 FT #SUB 163 163 VAL C 173 173 PRO D Protein B 3 FT #SUB 164 164 THR C 172 172 PHE D Protein S 2 FT #SUB 174 174 SER C 170 170 HIS D Protein S 4 FT #SUB 174 174 SER C 172 172 PHE D Protein B 2 FT #SUB 175 175 LEU C 172 172 PHE D Protein B 6 FT #SUB 176 176 SER C 172 172 PHE D Protein A 8 FT #SUB 208 208 SER C 135 135 LYS D Protein B 6 FT #SUB 209 209 PHE C 135 135 LYS D Protein A 2 FT #SUB 9 9 VAL C 11 1 011 F Protein S 1 FT #SUB 10 10 ILE C 11 1 011 F Protein S 1 FT #SUB 38 38 GLN C 2 3 PHE F Protein S 1 FT #SUB 38 38 GLN C 7 8 C6D F Protein S 4 FT #SUB 38 38 GLN C 8 9 ARG F Protein B 2 FT #SUB 39 39 ARG C 8 9 ARG F Protein B 2 FT #SUB 40 40 THR C 6 7 THR F Protein A 3 FT #SUB 40 40 THR C 8 9 ARG F Protein A 6 FT #SUB 41 41 ASN C 5 6 SER F Protein S 1 FT #SUB 41 41 ASN C 6 7 THR F Protein A 6 FT #SUB 41 41 ASN C 7 8 C6D F Protein B 3 FT #SUB 42 42 GLY C 7 8 C6D F Protein B 4 FT #SUB 43 43 SER C 7 8 C6D F Protein S 1 FT #SUB 84 84 ALA C 8 9 ARG F Protein B 7 FT #SUB 85 85 ASP C 8 9 ARG F Protein A 16 FT #SUB 85 85 ASP C 9 10 LEU F Protein S 12 FT #SUB 87 87 TYR C 9 10 LEU F Protein S 2 FT #SUB 100 100 ALA C 9 10 LEU F Protein B 1 FT #SUB 101 101 GLY C 9 10 LEU F Protein B 1 FT #SUB 103 103 LYS C 8 9 ARG F Protein S 2 FT #SUB 103 103 LYS C 9 10 LEU F Protein A 4 FT #SUB 165 165 GLU C 6 7 THR F Protein S 1 FT #SUB 165 165 GLU C 8 9 ARG F Protein S 5 FT #HET 156 156 SER C 2 301 SO4 C A 7 FT #HET 157 157 GLY C 2 301 SO4 C B 4 FT #HET 159 159 SER C 2 301 SO4 C S 1 FT DISORDER 213 213 CC SEQUENCE 212 AA (ATOM); CC DILLTQSPVI LSVSPGERVS FSCRASQSIG TNIHWYQQRT NGSPRLLIKY ASESISGIPS CC RFSGSGSGTD FTLSINSVES EDIADYYCQQ NNNWPTTFGA GTKLELKRTV AAPSVFIFPP CC SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT CC LSKADYEKHK VYACEVTHQG LSSPVTKSFN RG CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKY CC ATOM DILLTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKY CC ************************************************** CC SEQRES ASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGA CC ATOM ASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQNNNWPTTFGA CC ************************************************** CC SEQRES GTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV CC ATOM GTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV CC ************************************************** CC SEQRES DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG CC ATOM DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG CC ************************************************** CC SEQRES LSSPVTKSFNRGA CC ATOM LSSPVTKSFNRG- CC ************ SQ SEQUENCE 213 AA; MW; CN; DILLTQSPVI LSVSPGERVS FSCRASQSIG TNIHWYQQRT NGSPRLLIKY ASESISGIPS RFSGSGSGTD FTLSINSVES EDIADYYCQQ NNNWPTTFGA GTKLELKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGA // ID 6AZKD STANDARD; PRT; 221 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE cetuximab Fab heavy chain OS Mus musculus, Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 39 39 GLN D 38 38 GLN C Protein S 7 FT #SUB 39 39 GLN D 87 87 TYR C Protein S 3 FT #SUB 45 45 LEU D 87 87 TYR C Protein S 3 FT #SUB 45 45 LEU D 98 98 PHE C Protein A 6 FT #SUB 47 47 TRP D 94 94 TRP C Protein S 4 FT #SUB 47 47 TRP D 95 95 PRO C Protein S 1 FT #SUB 47 47 TRP D 96 96 THR C Protein S 5 FT #SUB 59 59 TYR D 94 94 TRP C Protein B 2 FT #SUB 60 60 ASN D 95 95 PRO C Protein S 5 FT #SUB 61 61 THR D 94 94 TRP C Protein A 3 FT #SUB 94 94 TYR D 38 38 GLN C Protein S 1 FT #SUB 94 94 TYR D 43 43 SER C Protein S 4 FT #SUB 94 94 TYR D 44 44 PRO C Protein S 2 FT #SUB 99 99 LEU D 49 49 LYS C Protein S 2 FT #SUB 103 103 ASP D 50 50 TYR C Protein S 5 FT #SUB 103 103 ASP D 91 91 ASN C Protein S 1 FT #SUB 104 104 TYR D 89 89 GLN C Protein B 3 FT #SUB 104 104 TYR D 91 91 ASN C Protein S 8 FT #SUB 105 105 GLU D 34 34 HIS C Protein S 5 FT #SUB 105 105 GLU D 36 36 TYR C Protein B 1 FT #SUB 105 105 GLU D 50 50 TYR C Protein S 1 FT #SUB 106 106 PHE D 36 36 TYR C Protein A 6 FT #SUB 106 106 PHE D 46 46 LEU C Protein B 1 FT #SUB 106 106 PHE D 89 89 GLN C Protein S 2 FT #SUB 107 107 ALA D 46 46 LEU C Protein A 3 FT #SUB 109 109 TRP D 36 36 TYR C Protein S 1 FT #SUB 109 109 TRP D 43 43 SER C Protein S 1 FT #SUB 109 109 TRP D 44 44 PRO C Protein S 13 FT #SUB 110 110 GLY D 43 43 SER C Protein B 3 FT #SUB 111 111 GLN D 43 43 SER C Protein B 3 FT #SUB 128 128 PHE D 121 121 SER C Protein S 2 FT #SUB 128 128 PHE D 124 124 GLN C Protein S 14 FT #SUB 129 129 PRO D 121 121 SER C Protein S 3 FT #SUB 129 129 PRO D 123 123 GLU C Protein S 2 FT #SUB 130 130 LEU D 118 118 PHE C Protein A 5 FT #SUB 130 130 LEU D 133 133 VAL C Protein S 1 FT #SUB 131 131 ALA D 118 118 PHE C Protein B 4 FT #SUB 135 135 LYS D 116 116 PHE C Protein B 2 FT #SUB 135 135 LYS D 117 117 ILE C Protein A 5 FT #SUB 135 135 LYS D 208 208 SER C Protein S 6 FT #SUB 135 135 LYS D 209 209 PHE C Protein S 2 FT #SUB 136 136 SER D 116 116 PHE C Protein B 6 FT #SUB 136 136 SER D 118 118 PHE C Protein S 3 FT #SUB 143 143 ALA D 116 116 PHE C Protein S 3 FT #SUB 143 143 ALA D 118 118 PHE C Protein A 5 FT #SUB 147 147 LEU D 131 131 SER C Protein S 2 FT #SUB 149 149 LYS D 124 124 GLN C Protein S 2 FT #SUB 149 149 LYS D 131 131 SER C Protein S 2 FT #SUB 170 170 HIS D 137 137 ASN C Protein S 2 FT #SUB 170 170 HIS D 138 138 ASN C Protein S 2 FT #SUB 170 170 HIS D 174 174 SER C Protein S 4 FT #SUB 172 172 PHE D 135 135 LEU C Protein S 2 FT #SUB 172 172 PHE D 162 162 SER C Protein S 3 FT #SUB 172 172 PHE D 164 164 THR C Protein S 2 FT #SUB 172 172 PHE D 174 174 SER C Protein S 2 FT #SUB 172 172 PHE D 175 175 LEU C Protein S 6 FT #SUB 172 172 PHE D 176 176 SER C Protein S 8 FT #SUB 173 173 PRO D 162 162 SER C Protein A 8 FT #SUB 173 173 PRO D 163 163 VAL C Protein S 3 FT #SUB 175 175 VAL D 160 160 GLN C Protein S 2 FT #SUB 175 175 VAL D 161 161 GLU C Protein S 1 FT #SUB 176 176 LEU D 160 160 GLN C Protein B 3 FT #SUB 177 177 GLN D 160 160 GLN C Protein A 2 FT #SUB 187 187 VAL D 135 135 LEU C Protein S 1 FT #SUB 189 189 THR D 137 137 ASN C Protein S 1 FT #SUB 215 215 LYS D 123 123 GLU C Protein S 1 FT #SUB 220 220 LYS D 122 122 ASP C Protein S 4 FT #SUB 9 9 PRO D 7 8 C6D F Protein S 3 FT #SUB 39 39 GLN D 2 3 PHE F Protein A 16 FT #SUB 39 39 GLN D 4 5 LEU F Protein B 1 FT #SUB 40 40 SER D 2 3 PHE F Protein B 3 FT #SUB 41 41 PRO D 1 2 GLN F Protein A 6 FT #SUB 41 41 PRO D 2 3 PHE F Protein A 4 FT #SUB 90 90 THR D 4 5 LEU F Protein A 2 FT #SUB 91 91 ALA D 4 5 LEU F Protein B 1 FT #SUB 92 92 ILE D 4 5 LEU F Protein A 3 FT #SUB 92 92 ILE D 7 8 C6D F Protein S 3 FT #SUB 94 94 TYR D 7 8 C6D F Protein S 4 FT #SUB 111 111 GLN D 7 8 C6D F Protein B 6 FT #SUB 112 112 GLY D 7 8 C6D F Protein B 3 FT #SUB 113 113 THR D 7 8 C6D F Protein B 5 FT #SUB 114 114 LEU D 7 8 C6D F Protein A 6 FT #SUB 154 154 GLU D 5 6 SER F Protein S 4 FT #SUB 173 173 PRO D 6 7 THR F Protein S 2 FT DISORDER 221 221 CC SEQUENCE 220 AA (ATOM); CC QVQLKQSGPG LVQPSQSLSI TCTVSGFSLT NYGVHWVRQS PGKGLEWLGV IWSGGNTDYN CC TPFTSRLSIN KDNSKSQVFF KMNSLQSNDT AIYYCARALT YYDYEFAYWG QGTLVTVSAA CC STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG CC LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGV CC ATOM QVQLKQSGPGLVQPSQSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGV CC ************************************************** CC SEQRES IWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALT CC ATOM IWSGGNTDYNTPFTSRLSINKDNSKSQVFFKMNSLQSNDTAIYYCARALT CC ************************************************** CC SEQRES YYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKD CC ATOM YYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKD CC ************************************************** CC SEQRES YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY CC ATOM YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY CC ************************************************** CC SEQRES ICNVNHKPSNTKVDKRVEPKS CC ATOM ICNVNHKPSNTKVDKRVEPK- CC ******************** SQ SEQUENCE 221 AA; MW; CN; QVQLKQSGPG LVQPSQSLSI TCTVSGFSLT NYGVHWVRQS PGKGLEWLGV IWSGGNTDYN TPFTSRLSIN KDNSKSQVFF KMNSLQSNDT AIYYCARALT YYDYEFAYWG QGTLVTVSAA STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK S // ID 6AZKE STANDARD; PRT; 11 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE meditope OS syntetic CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 2 3 PHE E 38 38 GLN A Protein S 1 FT #SUB 5 6 SER E 41 41 ASN A Protein B 1 FT #SUB 6 7 THR E 40 40 THR A Protein B 3 FT #SUB 6 7 THR E 41 41 ASN A Protein B 6 FT #SUB 6 7 THR E 165 165 GLU A Protein S 1 FT #SUB 7 8 C6D E 38 38 GLN A Protein A 5 FT #SUB 7 8 C6D E 41 41 ASN A Protein S 1 FT #SUB 7 8 C6D E 42 42 GLY A Protein S 3 FT #SUB 7 8 C6D E 43 43 SER A Protein S 2 FT #SUB 8 9 ARG E 38 38 GLN A Protein S 2 FT #SUB 8 9 ARG E 39 39 ARG A Protein S 2 FT #SUB 8 9 ARG E 40 40 THR A Protein S 6 FT #SUB 8 9 ARG E 84 84 ALA A Protein S 6 FT #SUB 8 9 ARG E 85 85 ASP A Protein A 14 FT #SUB 8 9 ARG E 103 103 LYS A Protein S 2 FT #SUB 8 9 ARG E 165 165 GLU A Protein S 3 FT #SUB 9 10 LEU E 85 85 ASP A Protein A 8 FT #SUB 9 10 LEU E 87 87 TYR A Protein S 3 FT #SUB 9 10 LEU E 100 100 ALA A Protein S 2 FT #SUB 9 10 LEU E 101 101 GLY A Protein S 2 FT #SUB 9 10 LEU E 103 103 LYS A Protein B 3 FT #SUB 11 1 011 E 9 9 VAL A Protein S 3 FT #SUB 11 1 011 E 10 10 ILE A Protein S 1 FT #SUB 1 2 GLN E 41 41 PRO B Protein S 3 FT #SUB 2 3 PHE E 39 39 GLN B Protein S 15 FT #SUB 2 3 PHE E 40 40 SER B Protein S 2 FT #SUB 2 3 PHE E 41 41 PRO B Protein B 3 FT #SUB 2 3 PHE E 92 92 ILE B Protein S 2 FT #SUB 4 5 LEU E 39 39 GLN B Protein S 1 FT #SUB 4 5 LEU E 41 41 PRO B Protein S 3 FT #SUB 4 5 LEU E 90 90 THR B Protein S 1 FT #SUB 4 5 LEU E 91 91 ALA B Protein S 2 FT #SUB 4 5 LEU E 92 92 ILE B Protein S 2 FT #SUB 4 5 LEU E 114 114 LEU B Protein S 2 FT #SUB 5 6 SER E 154 154 GLU B Protein A 4 FT #SUB 6 7 THR E 173 173 PRO B Protein S 2 FT #SUB 7 8 C6D E 9 9 PRO B Protein S 3 FT #SUB 7 8 C6D E 92 92 ILE B Protein S 3 FT #SUB 7 8 C6D E 94 94 TYR B Protein S 3 FT #SUB 7 8 C6D E 111 111 GLN B Protein S 6 FT #SUB 7 8 C6D E 112 112 GLY B Protein S 5 FT #SUB 7 8 C6D E 113 113 THR B Protein S 2 FT #SUB 7 8 C6D E 114 114 LEU B Protein S 5 FT #SUB 7 8 C6D E 155 155 PRO B Protein S 1 CC SEQUENCE 11 AA (ATOM); CC QFDLSTXRLK X CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QFDLSTXRLKX CC ATOM QFDLSTXRLKX CC *********** SQ SEQUENCE 11 AA; MW; CN; QFDLSTXRLK X // ID 6AZKF STANDARD; PRT; 11 AA. DT CONVERTED FROM PDB (SEQRES) 6AZK DE meditope OS syntetic CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.480 CC R-Factor 0.172 FT #SUB 2 3 PHE F 38 38 GLN C Protein S 1 FT #SUB 5 6 SER F 41 41 ASN C Protein B 1 FT #SUB 6 7 THR F 40 40 THR C Protein B 3 FT #SUB 6 7 THR F 41 41 ASN C Protein B 6 FT #SUB 6 7 THR F 165 165 GLU C Protein S 1 FT #SUB 7 8 C6D F 38 38 GLN C Protein A 4 FT #SUB 7 8 C6D F 41 41 ASN C Protein S 3 FT #SUB 7 8 C6D F 42 42 GLY C Protein S 4 FT #SUB 7 8 C6D F 43 43 SER C Protein S 1 FT #SUB 8 9 ARG F 38 38 GLN C Protein S 2 FT #SUB 8 9 ARG F 39 39 ARG C Protein S 2 FT #SUB 8 9 ARG F 40 40 THR C Protein S 6 FT #SUB 8 9 ARG F 84 84 ALA C Protein S 7 FT #SUB 8 9 ARG F 85 85 ASP C Protein A 16 FT #SUB 8 9 ARG F 103 103 LYS C Protein S 2 FT #SUB 8 9 ARG F 165 165 GLU C Protein S 5 FT #SUB 9 10 LEU F 85 85 ASP C Protein A 12 FT #SUB 9 10 LEU F 87 87 TYR C Protein S 2 FT #SUB 9 10 LEU F 100 100 ALA C Protein S 1 FT #SUB 9 10 LEU F 101 101 GLY C Protein S 1 FT #SUB 9 10 LEU F 103 103 LYS C Protein A 4 FT #SUB 11 1 011 F 9 9 VAL C Protein S 1 FT #SUB 11 1 011 F 10 10 ILE C Protein S 1 FT #SUB 1 2 GLN F 41 41 PRO D Protein S 6 FT #SUB 2 3 PHE F 39 39 GLN D Protein S 16 FT #SUB 2 3 PHE F 40 40 SER D Protein S 3 FT #SUB 2 3 PHE F 41 41 PRO D Protein B 4 FT #SUB 4 5 LEU F 39 39 GLN D Protein S 1 FT #SUB 4 5 LEU F 90 90 THR D Protein S 2 FT #SUB 4 5 LEU F 91 91 ALA D Protein S 1 FT #SUB 4 5 LEU F 92 92 ILE D Protein A 3 FT #SUB 5 6 SER F 154 154 GLU D Protein A 4 FT #SUB 6 7 THR F 173 173 PRO D Protein S 2 FT #SUB 7 8 C6D F 9 9 PRO D Protein S 3 FT #SUB 7 8 C6D F 92 92 ILE D Protein S 3 FT #SUB 7 8 C6D F 94 94 TYR D Protein S 4 FT #SUB 7 8 C6D F 111 111 GLN D Protein S 6 FT #SUB 7 8 C6D F 112 112 GLY D Protein S 3 FT #SUB 7 8 C6D F 113 113 THR D Protein S 5 FT #SUB 7 8 C6D F 114 114 LEU D Protein S 6 CC SEQUENCE 11 AA (ATOM); CC QFDLSTXRLK X CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES QFDLSTXRLKX CC ATOM QFDLSTXRLKX CC *********** SQ SEQUENCE 11 AA; MW; CN; QFDLSTXRLK X //