ID 6AOGA STANDARD; PRT; 566 AA. DT CONVERTED FROM PDB (SEQRES) 6AOG DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.241 FT #SUB 30 30 THR A 252 296 TRP B Protein S 2 FT #SUB 33 33 LYS A 252 296 TRP B Protein S 2 FT #SUB 34 34 HIS A 249 293 VAL B Protein S 2 FT #SUB 34 34 HIS A 252 296 TRP B Protein A 9 FT #SUB 37 37 ARG A 252 296 TRP B Protein S 3 FT #SUB 37 37 ARG A 255 299 GLU B Protein S 6 FT #SUB 38 38 VAL A 249 293 VAL B Protein S 1 FT #SUB 41 41 THR A 248 292 PRO B Protein S 1 FT #SUB 143 168 HIS A 241 285 SER B Protein S 2 FT #SUB 143 168 HIS A 245 289 ALA B Protein S 3 FT #SUB 145 170 TYR A 245 289 ALA B Protein S 6 FT #SUB 145 170 TYR A 249 293 VAL B Protein S 2 FT #SUB 186 230 ILE A 246 290 ILE B Protein A 2 FT #SUB 187 231 PHE A 246 290 ILE B Protein S 3 FT #SUB 187 231 PHE A 249 293 VAL B Protein S 1 FT #SUB 189 233 SER A 253 297 MET B Protein S 1 FT #SUB 192 236 PHE A 253 297 MET B Protein S 1 FT #SUB 201 245 PHE A 252 296 TRP B Protein S 2 FT #SUB 201 245 PHE A 253 297 MET B Protein S 1 FT #SUB 241 285 SER A 143 168 HIS B Protein B 2 FT #SUB 241 285 SER A 205 249 GLU B Protein B 1 FT #SUB 242 286 SER A 205 249 GLU B Protein B 1 FT #SUB 245 289 ALA A 143 168 HIS B Protein S 3 FT #SUB 245 289 ALA A 145 170 TYR B Protein B 4 FT #SUB 246 290 ILE A 186 230 ILE B Protein S 2 FT #SUB 246 290 ILE A 187 231 PHE B Protein S 1 FT #SUB 249 293 VAL A 34 34 HIS B Protein S 2 FT #SUB 249 293 VAL A 38 38 VAL B Protein S 1 FT #SUB 249 293 VAL A 145 170 TYR B Protein S 2 FT #SUB 249 293 VAL A 187 231 PHE B Protein S 1 FT #SUB 250 294 LEU A 275 319 PHE B Protein S 2 FT #SUB 252 296 TRP A 30 30 THR B Protein S 1 FT #SUB 252 296 TRP A 34 34 HIS B Protein S 7 FT #SUB 252 296 TRP A 37 37 ARG B Protein S 2 FT #SUB 252 296 TRP A 201 245 PHE B Protein S 2 FT #SUB 253 297 MET A 187 231 PHE B Protein S 2 FT #SUB 253 297 MET A 189 233 SER B Protein S 1 FT #SUB 253 297 MET A 201 245 PHE B Protein S 1 FT #SUB 275 319 PHE A 250 294 LEU B Protein S 2 FT #SUB 295 339 ARG A 454 498 ASN B Protein S 2 FT #SUB 295 339 ARG A 455 499 ASP B Protein A 5 FT #SUB 295 339 ARG A 456 500 GLN B Protein S 1 FT #SUB 296 340 THR A 455 499 ASP B Protein B 5 FT #SUB 297 341 MET A 423 467 THR B Protein S 1 FT #SUB 297 341 MET A 453 497 VAL B Protein S 1 FT #SUB 297 341 MET A 454 498 ASN B Protein S 5 FT #SUB 297 341 MET A 455 499 ASP B Protein S 2 FT #SUB 298 342 ASP A 423 467 THR B Protein B 3 FT #SUB 299 343 ASP A 425 469 ARG B Protein S 5 FT #SUB 300 344 ARG A 426 470 ARG B Protein S 5 FT #SUB 305 349 VAL A 425 469 ARG B Protein S 1 FT #SUB 307 351 SER A 452 496 TYR B Protein A 6 FT #SUB 309 353 PHE A 314 358 ARG B Protein B 4 FT #SUB 309 353 PHE A 450 494 GLN B Protein S 3 FT #SUB 309 353 PHE A 452 496 TYR B Protein S 13 FT #SUB 309 353 PHE A 460 504 SER B Protein S 3 FT #SUB 309 353 PHE A 461 505 CYS B Protein S 2 FT #SUB 309 353 PHE A 462 506 ILE B Protein S 8 FT #SUB 309 353 PHE A 500 544 ILE B Protein A 3 FT #SUB 310 354 GLY A 314 358 ARG B Protein B 4 FT #SUB 310 354 GLY A 462 506 ILE B Protein B 2 FT #SUB 310 354 GLY A 500 544 ILE B Protein B 1 FT #SUB 310 354 GLY A 502 546 PHE B Protein B 1 FT #SUB 312 356 THR A 502 546 PHE B Protein S 2 FT #SUB 314 358 ARG A 309 353 PHE B Protein S 2 FT #SUB 314 358 ARG A 310 354 GLY B Protein S 4 FT #SUB 392 436 PHE A 433 477 ASN B Protein S 1 FT #SUB 392 436 PHE A 434 478 PRO B Protein S 6 FT #SUB 408 452 VAL A 434 478 PRO B Protein S 3 FT #SUB 408 452 VAL A 435 479 ALA B Protein S 2 FT #SUB 410 454 GLN A 434 478 PRO B Protein S 2 FT #SUB 423 467 THR A 297 341 MET B Protein S 1 FT #SUB 423 467 THR A 298 342 ASP B Protein S 2 FT #SUB 425 469 ARG A 299 343 ASP B Protein S 5 FT #SUB 425 469 ARG A 305 349 VAL B Protein S 1 FT #SUB 425 469 ARG A 466 510 ARG B Protein A 5 FT #SUB 425 469 ARG A 467 511 SER B Protein S 5 FT #SUB 425 469 ARG A 505 549 ASN B Protein S 6 FT #SUB 425 469 ARG A 507 551 HIS B Protein S 11 FT #SUB 425 469 ARG A 509 553 TYR B Protein S 5 FT #SUB 426 470 ARG A 300 344 ARG B Protein S 2 FT #SUB 426 470 ARG A 443 487 PRO B Protein S 5 FT #SUB 426 470 ARG A 466 510 ARG B Protein S 5 FT #SUB 428 472 LEU A 447 491 LEU B Protein S 1 FT #SUB 428 472 LEU A 466 510 ARG B Protein S 2 FT #SUB 430 474 THR A 432 476 TRP B Protein S 1 FT #SUB 430 474 THR A 434 478 PRO B Protein S 1 FT #SUB 432 476 TRP A 428 472 LEU B Protein S 1 FT #SUB 432 476 TRP A 430 474 THR B Protein S 1 FT #SUB 433 477 ASN A 392 436 PHE B Protein S 1 FT #SUB 434 478 PRO A 392 436 PHE B Protein S 3 FT #SUB 434 478 PRO A 408 452 VAL B Protein B 1 FT #SUB 434 478 PRO A 410 454 GLN B Protein S 2 FT #SUB 434 478 PRO A 430 474 THR B Protein S 2 FT #SUB 435 479 ALA A 408 452 VAL B Protein B 1 FT #SUB 442 486 LEU A 426 470 ARG B Protein S 1 FT #SUB 443 487 PRO A 426 470 ARG B Protein S 7 FT #SUB 447 491 LEU A 428 472 LEU B Protein S 1 FT #SUB 447 491 LEU A 448 492 LEU B Protein S 1 FT #SUB 448 492 LEU A 447 491 LEU B Protein S 1 FT #SUB 448 492 LEU A 464 508 TYR B Protein S 2 FT #SUB 450 494 GLN A 309 353 PHE B Protein A 6 FT #SUB 450 494 GLN A 464 508 TYR B Protein S 5 FT #SUB 450 494 GLN A 466 510 ARG B Protein S 10 FT #SUB 450 494 GLN A 504 548 GLY B Protein S 1 FT #SUB 452 496 TYR A 307 351 SER B Protein S 5 FT #SUB 452 496 TYR A 309 353 PHE B Protein S 16 FT #SUB 452 496 TYR A 505 549 ASN B Protein S 2 FT #SUB 453 497 VAL A 297 341 MET B Protein B 1 FT #SUB 454 498 ASN A 295 339 ARG B Protein S 1 FT #SUB 454 498 ASN A 297 341 MET B Protein B 3 FT #SUB 455 499 ASP A 295 339 ARG B Protein S 3 FT #SUB 455 499 ASP A 296 340 THR B Protein S 2 FT #SUB 455 499 ASP A 297 341 MET B Protein B 1 FT #SUB 456 500 GLN A 295 339 ARG B Protein S 1 FT #SUB 460 504 SER A 309 353 PHE B Protein A 2 FT #SUB 462 506 ILE A 309 353 PHE B Protein A 7 FT #SUB 462 506 ILE A 310 354 GLY B Protein S 2 FT #SUB 462 506 ILE A 464 508 TYR B Protein S 4 FT #SUB 462 506 ILE A 503 547 MET B Protein S 1 FT #SUB 462 506 ILE A 504 548 GLY B Protein S 1 FT #SUB 464 508 TYR A 448 492 LEU B Protein S 2 FT #SUB 464 508 TYR A 450 494 GLN B Protein S 5 FT #SUB 464 508 TYR A 462 506 ILE B Protein S 5 FT #SUB 464 508 TYR A 502 546 PHE B Protein S 3 FT #SUB 466 510 ARG A 425 469 ARG B Protein S 6 FT #SUB 466 510 ARG A 426 470 ARG B Protein S 4 FT #SUB 466 510 ARG A 428 472 LEU B Protein S 2 FT #SUB 466 510 ARG A 450 494 GLN B Protein A 11 FT #SUB 467 511 SER A 425 469 ARG B Protein S 5 FT #SUB 500 544 ILE A 309 353 PHE B Protein S 1 FT #SUB 500 544 ILE A 310 354 GLY B Protein S 1 FT #SUB 502 546 PHE A 310 354 GLY B Protein S 3 FT #SUB 502 546 PHE A 311 355 CYS B Protein S 1 FT #SUB 502 546 PHE A 312 356 THR B Protein S 2 FT #SUB 502 546 PHE A 464 508 TYR B Protein S 3 FT #SUB 502 546 PHE A 502 546 PHE B Protein S 8 FT #SUB 502 546 PHE A 503 547 MET B Protein S 3 FT #SUB 503 547 MET A 462 506 ILE B Protein B 1 FT #SUB 503 547 MET A 502 546 PHE B Protein B 1 FT #SUB 504 548 GLY A 450 494 GLN B Protein B 1 FT #SUB 504 548 GLY A 462 506 ILE B Protein B 1 FT #SUB 505 549 ASN A 425 469 ARG B Protein S 6 FT #SUB 505 549 ASN A 450 494 GLN B Protein B 1 FT #SUB 505 549 ASN A 452 496 TYR B Protein S 3 FT #SUB 507 551 HIS A 425 469 ARG B Protein S 11 FT #SUB 509 553 TYR A 425 469 ARG B Protein S 5 FT #HET 8 8 VAL A 4 704 CP6 A A 11 FT #HET 9 9 VAL A 2 702 NDP A A 4 FT #HET 9 9 VAL A 4 704 CP6 A B 15 FT #HET 10 10 ALA A 2 702 NDP A A 9 FT #HET 10 10 ALA A 4 704 CP6 A A 6 FT #HET 17 17 ILE A 2 702 NDP A A 9 FT #HET 21 21 ASN A 2 702 NDP A A 7 FT #HET 22 22 GLY A 2 702 NDP A B 9 FT #HET 23 23 LEU A 2 702 NDP A A 4 FT #HET 25 25 TRP A 2 702 NDP A S 2 FT #HET 31 31 ASP A 4 704 CP6 A S 9 FT #HET 32 32 PHE A 4 704 CP6 A A 2 FT #HET 34 34 HIS A 4 704 CP6 A S 1 FT #HET 35 35 PHE A 4 704 CP6 A S 8 FT #HET 55 80 GLY A 2 702 NDP A B 7 FT #HET 56 81 ARG A 2 702 NDP A A 20 FT #HET 57 82 LYS A 2 702 NDP A A 7 FT #HET 58 83 THR A 2 702 NDP A A 11 FT #HET 58 83 THR A 4 704 CP6 A A 2 FT #HET 61 86 SER A 2 702 NDP A S 3 FT #HET 62 87 MET A 4 704 CP6 A S 1 FT #HET 77 102 VAL A 2 702 NDP A A 9 FT #HET 78 103 SER A 2 702 NDP A A 6 FT #HET 79 104 SER A 2 702 NDP A A 6 FT #HET 80 105 SER A 2 702 NDP A A 3 FT #HET 103 128 ALA A 2 702 NDP A B 3 FT #HET 126 151 VAL A 2 702 NDP A B 2 FT #HET 126 151 VAL A 4 704 CP6 A A 5 FT #HET 127 152 GLY A 2 702 NDP A B 3 FT #HET 128 153 GLY A 2 702 NDP A B 11 FT #HET 129 154 ALA A 2 702 NDP A A 5 FT #HET 130 155 GLY A 2 702 NDP A B 6 FT #HET 131 156 LEU A 2 702 NDP A A 3 FT #HET 132 157 TYR A 2 702 NDP A S 2 FT #HET 132 157 TYR A 4 704 CP6 A S 1 FT #HET 147 172 THR A 4 704 CP6 A S 3 FT #HET 157 182 VAL A 2 702 NDP A S 5 FT #HET 300 344 ARG A 1 701 UMP A S 12 FT #HET 327 371 LYS A 3 703 CB3 A S 7 FT #HET 328 372 ARG A 3 703 CB3 A B 2 FT #HET 329 373 VAL A 3 703 CB3 A B 1 FT #HET 330 374 PHE A 3 703 CB3 A A 3 FT #HET 337 381 GLU A 3 703 CB3 A S 1 FT #HET 358 402 ILE A 3 703 CB3 A A 15 FT #HET 362 406 ASN A 3 703 CB3 A S 1 FT #HET 425 469 ARG A 5 701 UMP B S 10 FT #HET 426 470 ARG A 5 701 UMP B S 6 FT #HET 442 486 LEU A 1 701 UMP A S 1 FT #HET 445 489 CYS A 1 701 UMP A S 13 FT #HET 446 490 HIS A 1 701 UMP A S 2 FT #HET 465 509 GLN A 1 701 UMP A S 3 FT #HET 466 510 ARG A 1 701 UMP A S 8 FT #HET 467 511 SER A 1 701 UMP A A 8 FT #HET 468 512 CYS A 1 701 UMP A B 1 FT #HET 469 513 ASP A 1 701 UMP A A 4 FT #HET 469 513 ASP A 3 703 CB3 A S 10 FT #HET 472 516 LEU A 3 703 CB3 A A 15 FT #HET 473 517 GLY A 3 703 CB3 A B 5 FT #HET 476 520 PHE A 3 703 CB3 A S 15 FT #HET 477 521 ASN A 1 701 UMP A S 8 FT #HET 477 521 ASN A 3 703 CB3 A S 4 FT #HET 507 551 HIS A 1 701 UMP A S 5 FT #HET 509 553 TYR A 1 701 UMP A S 3 FT #HET 509 553 TYR A 3 703 CB3 A S 3 FT #HET 559 603 ARG A 3 703 CB3 A S 4 FT #HET 564 608 MET A 3 703 CB3 A S 6 FT #HET 565 609 ALA A 3 703 CB3 A B 2 FT DISORDER 1 2 FT DISORDER 44 45 FT DISORDER 172 180 FT DISORDER 209 240 FT DISORDER 256 265 CC SEQUENCE 511 AA (ATOM); CC KPVCLVVAMT PKRGIGINNG LPWPHLTTDF KHFSRVTKTT PASRFNAVVM GRKTWESMPR CC KFRPLVDRLN IVVSSSLKEE DIAAEKPQAE GQQRVRVCAS LPAALSLLEE EYKDSVDQIF CC VVGGAGLYEA ALSLGVASHL YITRVAREFP CDVFFPAFPG DDILSNKATY RPIFISKTFS CC DNGVPYDFVV LEKRRSSAAA IAPVLAWMDE LIRAVPHVHF RGHEEFQYLD LIADIINNGR CC TMDDRTGVGV ISKFGCTMRY SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG CC VKIWDKNVTR EFLDSRNLPH REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI CC QMLRTNPTDR RMLMTAWNPA ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP CC FNIASYSLLT LMVAHVCNLK PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK CC ERIKEIDDFT AEDFEVVGYV PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRFN CC ATOM --KPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTP--ASRFN CC ***************************************** ***** CC SEQRES AVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVR CC ATOM AVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVR CC ************************************************** CC SEQRES VCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVA CC ATOM VCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVA CC ************************************************** CC SEQRES REFPCDVFFPAFPGDDILSNKSTAAEKDNEATYRPIFISKTFSDNGVPYD CC ATOM REFPCDVFFPAFPGDDILSNK---------ATYRPIFISKTFSDNGVPYD CC ********************* ******************** CC SEQRES FVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVL CC ATOM FVVLEKRR--------------------------------SSAAAIAPVL CC ******** ********** CC SEQRES AWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDR CC ATOM AWMDE----------LIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDR CC ***** *********************************** CC SEQRES TGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANH CC ATOM TGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANH CC ************************************************** CC SEQRES LSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMH CC ATOM LSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMH CC ************************************************** CC SEQRES TDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQ CC ATOM TDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQ CC ************************************************** CC SEQRES FYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFI CC ATOM FYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFI CC ************************************************** CC SEQRES HFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFE CC ATOM HFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFE CC ************************************************** CC SEQRES VVGYVPHGRIQMEMAV CC ATOM VVGYVPHGRIQMEMAV CC **************** SQ SEQUENCE 566 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRFN AVVMGRKTWE SMPRKFRPLV DRLNIVVSSS LKEEDIAAEK PQAEGQQRVR VCASLPAALS LLEEEYKDSV DQIFVVGGAG LYEAALSLGV ASHLYITRVA REFPCDVFFP AFPGDDILSN KSTAAEKDNE ATYRPIFISK TFSDNGVPYD FVVLEKRRKT DDAATAEPSN AMSSLTSTRE TTPVHGLQAP SSAAAIAPVL AWMDEEDRKK REQKELIRAV PHVHFRGHEE FQYLDLIADI INNGRTMDDR TGVGVISKFG CTMRYSLDQA FPLLTTKRVF WKGVLEELLW FIRGDTNANH LSEKGVKIWD KNVTREFLDS RNLPHREVGD IGPGYGFQWR HFGAAYKDMH TDYTGQGVDQ LKNVIQMLRT NPTDRRMLMT AWNPAALDEM ALPPCHLLCQ FYVNDQKELS CIMYQRSCDV GLGVPFNIAS YSLLTLMVAH VCNLKPKEFI HFMGNTHVYT NHVEALKEQL RREPRPFPIV NILNKERIKE IDDFTAEDFE VVGYVPHGRI QMEMAV // ID 6AOGB STANDARD; PRT; 566 AA. DT CONVERTED FROM PDB (SEQRES) 6AOG DE Bifunctional dihydrofolate reductase-thymidylate synthase OS Toxoplasma gondii CC EXPDTA X-RAY DIFFRACTION CC RESOLU 3.200 CC R-Factor 0.241 FT #SUB 30 30 THR B 252 296 TRP A Protein S 1 FT #SUB 34 34 HIS B 249 293 VAL A Protein S 2 FT #SUB 34 34 HIS B 252 296 TRP A Protein S 7 FT #SUB 37 37 ARG B 252 296 TRP A Protein S 2 FT #SUB 38 38 VAL B 249 293 VAL A Protein S 1 FT #SUB 143 168 HIS B 241 285 SER A Protein S 2 FT #SUB 143 168 HIS B 245 289 ALA A Protein S 3 FT #SUB 145 170 TYR B 245 289 ALA A Protein S 4 FT #SUB 145 170 TYR B 249 293 VAL A Protein S 2 FT #SUB 186 230 ILE B 246 290 ILE A Protein S 2 FT #SUB 187 231 PHE B 246 290 ILE A Protein S 1 FT #SUB 187 231 PHE B 249 293 VAL A Protein S 1 FT #SUB 187 231 PHE B 253 297 MET A Protein S 2 FT #SUB 189 233 SER B 253 297 MET A Protein S 1 FT #SUB 201 245 PHE B 252 296 TRP A Protein S 2 FT #SUB 201 245 PHE B 253 297 MET A Protein S 1 FT #SUB 205 249 GLU B 241 285 SER A Protein S 1 FT #SUB 205 249 GLU B 242 286 SER A Protein S 1 FT #SUB 241 285 SER B 143 168 HIS A Protein B 2 FT #SUB 245 289 ALA B 143 168 HIS A Protein S 3 FT #SUB 245 289 ALA B 145 170 TYR A Protein A 6 FT #SUB 246 290 ILE B 186 230 ILE A Protein S 2 FT #SUB 246 290 ILE B 187 231 PHE A Protein S 3 FT #SUB 248 292 PRO B 41 41 THR A Protein S 1 FT #SUB 249 293 VAL B 34 34 HIS A Protein S 2 FT #SUB 249 293 VAL B 38 38 VAL A Protein S 1 FT #SUB 249 293 VAL B 145 170 TYR A Protein S 2 FT #SUB 249 293 VAL B 187 231 PHE A Protein S 1 FT #SUB 250 294 LEU B 275 319 PHE A Protein S 2 FT #SUB 252 296 TRP B 30 30 THR A Protein S 2 FT #SUB 252 296 TRP B 33 33 LYS A Protein S 2 FT #SUB 252 296 TRP B 34 34 HIS A Protein S 9 FT #SUB 252 296 TRP B 37 37 ARG A Protein S 3 FT #SUB 252 296 TRP B 201 245 PHE A Protein S 2 FT #SUB 253 297 MET B 189 233 SER A Protein S 1 FT #SUB 253 297 MET B 192 236 PHE A Protein S 1 FT #SUB 253 297 MET B 201 245 PHE A Protein S 1 FT #SUB 255 299 GLU B 37 37 ARG A Protein S 6 FT #SUB 275 319 PHE B 250 294 LEU A Protein S 2 FT #SUB 295 339 ARG B 454 498 ASN A Protein S 1 FT #SUB 295 339 ARG B 455 499 ASP A Protein S 3 FT #SUB 295 339 ARG B 456 500 GLN A Protein S 1 FT #SUB 296 340 THR B 455 499 ASP A Protein B 2 FT #SUB 297 341 MET B 423 467 THR A Protein S 1 FT #SUB 297 341 MET B 453 497 VAL A Protein S 1 FT #SUB 297 341 MET B 454 498 ASN A Protein S 3 FT #SUB 297 341 MET B 455 499 ASP A Protein S 1 FT #SUB 298 342 ASP B 423 467 THR A Protein B 2 FT #SUB 299 343 ASP B 425 469 ARG A Protein S 5 FT #SUB 300 344 ARG B 426 470 ARG A Protein S 2 FT #SUB 305 349 VAL B 425 469 ARG A Protein S 1 FT #SUB 307 351 SER B 452 496 TYR A Protein A 5 FT #SUB 309 353 PHE B 314 358 ARG A Protein B 2 FT #SUB 309 353 PHE B 450 494 GLN A Protein S 6 FT #SUB 309 353 PHE B 452 496 TYR A Protein S 16 FT #SUB 309 353 PHE B 460 504 SER A Protein S 2 FT #SUB 309 353 PHE B 462 506 ILE A Protein S 7 FT #SUB 309 353 PHE B 500 544 ILE A Protein B 1 FT #SUB 310 354 GLY B 314 358 ARG A Protein B 4 FT #SUB 310 354 GLY B 462 506 ILE A Protein B 2 FT #SUB 310 354 GLY B 500 544 ILE A Protein B 1 FT #SUB 310 354 GLY B 502 546 PHE A Protein B 3 FT #SUB 311 355 CYS B 502 546 PHE A Protein B 1 FT #SUB 312 356 THR B 502 546 PHE A Protein S 2 FT #SUB 314 358 ARG B 309 353 PHE A Protein S 4 FT #SUB 314 358 ARG B 310 354 GLY A Protein S 4 FT #SUB 392 436 PHE B 433 477 ASN A Protein S 1 FT #SUB 392 436 PHE B 434 478 PRO A Protein S 3 FT #SUB 408 452 VAL B 434 478 PRO A Protein S 1 FT #SUB 408 452 VAL B 435 479 ALA A Protein S 1 FT #SUB 410 454 GLN B 434 478 PRO A Protein S 2 FT #SUB 423 467 THR B 297 341 MET A Protein S 1 FT #SUB 423 467 THR B 298 342 ASP A Protein S 3 FT #SUB 425 469 ARG B 299 343 ASP A Protein S 5 FT #SUB 425 469 ARG B 305 349 VAL A Protein S 1 FT #SUB 425 469 ARG B 466 510 ARG A Protein A 6 FT #SUB 425 469 ARG B 467 511 SER A Protein S 5 FT #SUB 425 469 ARG B 505 549 ASN A Protein S 6 FT #SUB 425 469 ARG B 507 551 HIS A Protein S 11 FT #SUB 425 469 ARG B 509 553 TYR A Protein S 5 FT #SUB 426 470 ARG B 300 344 ARG A Protein S 5 FT #SUB 426 470 ARG B 442 486 LEU A Protein S 1 FT #SUB 426 470 ARG B 443 487 PRO A Protein S 7 FT #SUB 426 470 ARG B 466 510 ARG A Protein S 4 FT #SUB 428 472 LEU B 432 476 TRP A Protein S 1 FT #SUB 428 472 LEU B 447 491 LEU A Protein S 1 FT #SUB 428 472 LEU B 466 510 ARG A Protein S 2 FT #SUB 430 474 THR B 432 476 TRP A Protein S 1 FT #SUB 430 474 THR B 434 478 PRO A Protein S 2 FT #SUB 432 476 TRP B 430 474 THR A Protein S 1 FT #SUB 433 477 ASN B 392 436 PHE A Protein S 1 FT #SUB 434 478 PRO B 392 436 PHE A Protein S 6 FT #SUB 434 478 PRO B 408 452 VAL A Protein A 3 FT #SUB 434 478 PRO B 410 454 GLN A Protein S 2 FT #SUB 434 478 PRO B 430 474 THR A Protein S 1 FT #SUB 435 479 ALA B 408 452 VAL A Protein B 2 FT #SUB 443 487 PRO B 426 470 ARG A Protein S 5 FT #SUB 447 491 LEU B 428 472 LEU A Protein S 1 FT #SUB 447 491 LEU B 448 492 LEU A Protein S 1 FT #SUB 448 492 LEU B 447 491 LEU A Protein S 1 FT #SUB 448 492 LEU B 464 508 TYR A Protein S 2 FT #SUB 450 494 GLN B 309 353 PHE A Protein A 3 FT #SUB 450 494 GLN B 464 508 TYR A Protein S 5 FT #SUB 450 494 GLN B 466 510 ARG A Protein S 11 FT #SUB 450 494 GLN B 504 548 GLY A Protein S 1 FT #SUB 450 494 GLN B 505 549 ASN A Protein S 1 FT #SUB 452 496 TYR B 307 351 SER A Protein S 6 FT #SUB 452 496 TYR B 309 353 PHE A Protein S 13 FT #SUB 452 496 TYR B 505 549 ASN A Protein S 3 FT #SUB 453 497 VAL B 297 341 MET A Protein B 1 FT #SUB 454 498 ASN B 295 339 ARG A Protein S 2 FT #SUB 454 498 ASN B 297 341 MET A Protein B 5 FT #SUB 455 499 ASP B 295 339 ARG A Protein S 5 FT #SUB 455 499 ASP B 296 340 THR A Protein S 5 FT #SUB 455 499 ASP B 297 341 MET A Protein A 2 FT #SUB 456 500 GLN B 295 339 ARG A Protein S 1 FT #SUB 460 504 SER B 309 353 PHE A Protein A 3 FT #SUB 461 505 CYS B 309 353 PHE A Protein B 2 FT #SUB 462 506 ILE B 309 353 PHE A Protein A 8 FT #SUB 462 506 ILE B 310 354 GLY A Protein S 2 FT #SUB 462 506 ILE B 464 508 TYR A Protein S 5 FT #SUB 462 506 ILE B 503 547 MET A Protein S 1 FT #SUB 462 506 ILE B 504 548 GLY A Protein S 1 FT #SUB 464 508 TYR B 448 492 LEU A Protein S 2 FT #SUB 464 508 TYR B 450 494 GLN A Protein S 5 FT #SUB 464 508 TYR B 462 506 ILE A Protein S 4 FT #SUB 464 508 TYR B 502 546 PHE A Protein S 3 FT #SUB 466 510 ARG B 425 469 ARG A Protein S 5 FT #SUB 466 510 ARG B 426 470 ARG A Protein S 5 FT #SUB 466 510 ARG B 428 472 LEU A Protein S 2 FT #SUB 466 510 ARG B 450 494 GLN A Protein A 10 FT #SUB 467 511 SER B 425 469 ARG A Protein S 5 FT #SUB 500 544 ILE B 309 353 PHE A Protein S 3 FT #SUB 500 544 ILE B 310 354 GLY A Protein S 1 FT #SUB 502 546 PHE B 310 354 GLY A Protein S 1 FT #SUB 502 546 PHE B 312 356 THR A Protein S 2 FT #SUB 502 546 PHE B 464 508 TYR A Protein S 3 FT #SUB 502 546 PHE B 502 546 PHE A Protein S 8 FT #SUB 502 546 PHE B 503 547 MET A Protein S 1 FT #SUB 503 547 MET B 462 506 ILE A Protein B 1 FT #SUB 503 547 MET B 502 546 PHE A Protein B 3 FT #SUB 504 548 GLY B 450 494 GLN A Protein B 1 FT #SUB 504 548 GLY B 462 506 ILE A Protein B 1 FT #SUB 505 549 ASN B 425 469 ARG A Protein S 6 FT #SUB 505 549 ASN B 452 496 TYR A Protein S 2 FT #SUB 507 551 HIS B 425 469 ARG A Protein S 11 FT #SUB 509 553 TYR B 425 469 ARG A Protein S 5 FT #HET 8 8 VAL B 8 704 CP6 B A 12 FT #HET 9 9 VAL B 6 702 NDP B A 4 FT #HET 9 9 VAL B 8 704 CP6 B B 15 FT #HET 10 10 ALA B 6 702 NDP B A 11 FT #HET 10 10 ALA B 8 704 CP6 B A 4 FT #HET 17 17 ILE B 6 702 NDP B A 4 FT #HET 18 18 GLY B 6 702 NDP B B 1 FT #HET 19 19 ILE B 6 702 NDP B B 1 FT #HET 21 21 ASN B 6 702 NDP B A 8 FT #HET 22 22 GLY B 6 702 NDP B B 9 FT #HET 23 23 LEU B 6 702 NDP B A 2 FT #HET 25 25 TRP B 6 702 NDP B S 2 FT #HET 31 31 ASP B 8 704 CP6 B S 10 FT #HET 32 32 PHE B 8 704 CP6 B A 2 FT #HET 34 34 HIS B 8 704 CP6 B S 1 FT #HET 35 35 PHE B 8 704 CP6 B S 12 FT #HET 55 80 GLY B 6 702 NDP B B 5 FT #HET 56 81 ARG B 6 702 NDP B A 26 FT #HET 57 82 LYS B 6 702 NDP B A 9 FT #HET 58 83 THR B 6 702 NDP B A 11 FT #HET 58 83 THR B 8 704 CP6 B A 2 FT #HET 61 86 SER B 6 702 NDP B S 1 FT #HET 62 87 MET B 8 704 CP6 B S 1 FT #HET 77 102 VAL B 6 702 NDP B A 8 FT #HET 79 104 SER B 6 702 NDP B A 6 FT #HET 80 105 SER B 6 702 NDP B A 2 FT #HET 103 128 ALA B 6 702 NDP B B 2 FT #HET 126 151 VAL B 6 702 NDP B B 2 FT #HET 126 151 VAL B 8 704 CP6 B A 5 FT #HET 127 152 GLY B 6 702 NDP B B 3 FT #HET 128 153 GLY B 6 702 NDP B B 12 FT #HET 129 154 ALA B 6 702 NDP B A 5 FT #HET 130 155 GLY B 6 702 NDP B B 7 FT #HET 131 156 LEU B 6 702 NDP B A 3 FT #HET 132 157 TYR B 6 702 NDP B S 2 FT #HET 132 157 TYR B 8 704 CP6 B S 1 FT #HET 134 159 ALA B 6 702 NDP B S 1 FT #HET 147 172 THR B 8 704 CP6 B S 3 FT #HET 157 182 VAL B 6 702 NDP B S 2 FT #HET 300 344 ARG B 5 701 UMP B S 9 FT #HET 327 371 LYS B 7 703 CB3 B S 4 FT #HET 328 372 ARG B 7 703 CB3 B B 1 FT #HET 330 374 PHE B 7 703 CB3 B S 1 FT #HET 337 381 GLU B 7 703 CB3 B S 1 FT #HET 358 402 ILE B 7 703 CB3 B A 12 FT #HET 359 403 TRP B 7 703 CB3 B S 5 FT #HET 362 406 ASN B 7 703 CB3 B S 2 FT #HET 385 429 TYR B 5 701 UMP B S 1 FT #HET 425 469 ARG B 1 701 UMP A S 11 FT #HET 426 470 ARG B 1 701 UMP A S 8 FT #HET 442 486 LEU B 5 701 UMP B S 2 FT #HET 445 489 CYS B 5 701 UMP B S 11 FT #HET 446 490 HIS B 5 701 UMP B S 2 FT #HET 465 509 GLN B 5 701 UMP B S 4 FT #HET 466 510 ARG B 5 701 UMP B S 8 FT #HET 467 511 SER B 5 701 UMP B A 10 FT #HET 468 512 CYS B 5 701 UMP B B 2 FT #HET 469 513 ASP B 5 701 UMP B A 6 FT #HET 469 513 ASP B 7 703 CB3 B S 9 FT #HET 472 516 LEU B 7 703 CB3 B A 12 FT #HET 473 517 GLY B 5 701 UMP B B 1 FT #HET 473 517 GLY B 7 703 CB3 B B 5 FT #HET 476 520 PHE B 7 703 CB3 B A 14 FT #HET 477 521 ASN B 5 701 UMP B S 10 FT #HET 477 521 ASN B 7 703 CB3 B S 3 FT #HET 507 551 HIS B 5 701 UMP B S 5 FT #HET 509 553 TYR B 5 701 UMP B S 2 FT #HET 509 553 TYR B 7 703 CB3 B S 3 FT #HET 559 603 ARG B 7 703 CB3 B S 1 FT #HET 564 608 MET B 7 703 CB3 B S 1 FT #HET 565 609 ALA B 7 703 CB3 B A 2 FT DISORDER 1 3 FT DISORDER 44 45 FT DISORDER 172 180 FT DISORDER 209 240 FT DISORDER 257 265 CC SEQUENCE 511 AA (ATOM); CC PVCLVVAMTP KRGIGINNGL PWPHLTTDFK HFSRVTKTTP ASRFNAVVMG RKTWESMPRK CC FRPLVDRLNI VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV CC VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKATYR PIFISKTFSD CC NGVPYDFVVL EKRRSSAAAI APVLAWMDEE LIRAVPHVHF RGHEEFQYLD LIADIINNGR CC TMDDRTGVGV ISKFGCTMRY SLDQAFPLLT TKRVFWKGVL EELLWFIRGD TNANHLSEKG CC VKIWDKNVTR EFLDSRNLPH REVGDIGPGY GFQWRHFGAA YKDMHTDYTG QGVDQLKNVI CC QMLRTNPTDR RMLMTAWNPA ALDEMALPPC HLLCQFYVND QKELSCIMYQ RSCDVGLGVP CC FNIASYSLLT LMVAHVCNLK PKEFIHFMGN THVYTNHVEA LKEQLRREPR PFPIVNILNK CC ERIKEIDDFT AEDFEVVGYV PHGRIQMEMA V CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRFN CC ATOM ---PVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTP--ASRFN CC **************************************** ***** CC SEQRES AVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVR CC ATOM AVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVR CC ************************************************** CC SEQRES VCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVA CC ATOM VCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVA CC ************************************************** CC SEQRES REFPCDVFFPAFPGDDILSNKSTAAEKDNEATYRPIFISKTFSDNGVPYD CC ATOM REFPCDVFFPAFPGDDILSNK---------ATYRPIFISKTFSDNGVPYD CC ********************* ******************** CC SEQRES FVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVL CC ATOM FVVLEKRR--------------------------------SSAAAIAPVL CC ******** ********** CC SEQRES AWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDR CC ATOM AWMDEE---------LIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDR CC ****** *********************************** CC SEQRES TGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANH CC ATOM TGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANH CC ************************************************** CC SEQRES LSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMH CC ATOM LSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMH CC ************************************************** CC SEQRES TDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQ CC ATOM TDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQ CC ************************************************** CC SEQRES FYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFI CC ATOM FYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFI CC ************************************************** CC SEQRES HFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFE CC ATOM HFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFE CC ************************************************** CC SEQRES VVGYVPHGRIQMEMAV CC ATOM VVGYVPHGRIQMEMAV CC **************** SQ SEQUENCE 566 AA; MW; CN; MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRFN AVVMGRKTWE SMPRKFRPLV DRLNIVVSSS LKEEDIAAEK PQAEGQQRVR VCASLPAALS LLEEEYKDSV DQIFVVGGAG LYEAALSLGV ASHLYITRVA REFPCDVFFP AFPGDDILSN KSTAAEKDNE ATYRPIFISK TFSDNGVPYD FVVLEKRRKT DDAATAEPSN AMSSLTSTRE TTPVHGLQAP SSAAAIAPVL AWMDEEDRKK REQKELIRAV PHVHFRGHEE FQYLDLIADI INNGRTMDDR TGVGVISKFG CTMRYSLDQA FPLLTTKRVF WKGVLEELLW FIRGDTNANH LSEKGVKIWD KNVTREFLDS RNLPHREVGD IGPGYGFQWR HFGAAYKDMH TDYTGQGVDQ LKNVIQMLRT NPTDRRMLMT AWNPAALDEM ALPPCHLLCQ FYVNDQKELS CIMYQRSCDV GLGVPFNIAS YSLLTLMVAH VCNLKPKEFI HFMGNTHVYT NHVEALKEQL RREPRPFPIV NILNKERIKE IDDFTAEDFE VVGYVPHGRI QMEMAV //