ID	6A3NA	STANDARD;	PRT;	322	AA.
DT	CONVERTED FROM PDB (SEQRES) 6A3N
DE	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.249
FT	#SUB	124	 308 	ARG	A	165	 349 	PHE	B	Protein	S	6
FT	#SUB	128	 312 	ALA	A	169	 353 	ARG	B	Protein	B	2
FT	#SUB	129	 313 	VAL	A	143	 327 	ALA	B	Protein	A	3
FT	#SUB	129	 313 	VAL	A	147	 331 	GLN	B	Protein	S	1
FT	#SUB	129	 313 	VAL	A	169	 353 	ARG	B	Protein	B	1
FT	#SUB	130	 314 	ARG	A	130	 314 	ARG	B	Protein	S	1
FT	#SUB	130	 314 	ARG	A	131	 315 	TYR	B	Protein	A	5
FT	#SUB	130	 314 	ARG	A	143	 327 	ALA	B	Protein	B	1
FT	#SUB	131	 315 	TYR	A	130	 314 	ARG	B	Protein	S	5
FT	#SUB	131	 315 	TYR	A	131	 315 	TYR	B	Protein	S	4
FT	#SUB	132	 316 	ASN	A	139	 323 	ASN	B	Protein	S	9
FT	#SUB	132	 316 	ASN	A	142	 326 	CYS	B	Protein	S	4
FT	#SUB	132	 316 	ASN	A	143	 327 	ALA	B	Protein	S	2
FT	#SUB	132	 316 	ASN	A	169	 353 	ARG	B	Protein	B	2
FT	#SUB	132	 316 	ASN	A	173	 357 	ILE	B	Protein	A	4
FT	#SUB	133	 317 	ASP	A	169	 353 	ARG	B	Protein	A	11
FT	#SUB	134	 318 	ILE	A	177	 361 	LEU	B	Protein	S	1
FT	#SUB	139	 323 	ASN	A	132	 316 	ASN	B	Protein	A	8
FT	#SUB	142	 326 	CYS	A	132	 316 	ASN	B	Protein	A	4
FT	#SUB	143	 327 	ALA	A	129	 313 	VAL	B	Protein	A	2
FT	#SUB	143	 327 	ALA	A	130	 314 	ARG	B	Protein	S	1
FT	#SUB	143	 327 	ALA	A	132	 316 	ASN	B	Protein	B	2
FT	#SUB	147	 331 	GLN	A	129	 313 	VAL	B	Protein	B	1
FT	#SUB	165	 349 	PHE	A	124	 308 	ARG	B	Protein	S	8
FT	#SUB	169	 353 	ARG	A	128	 312 	ALA	B	Protein	S	2
FT	#SUB	169	 353 	ARG	A	129	 313 	VAL	B	Protein	S	1
FT	#SUB	169	 353 	ARG	A	132	 316 	ASN	B	Protein	S	2
FT	#SUB	169	 353 	ARG	A	133	 317 	ASP	B	Protein	S	12
FT	#SUB	173	 357 	ILE	A	132	 316 	ASN	B	Protein	S	1
FT	#SUB	177	 361 	LEU	A	134	 318 	ILE	B	Protein	S	1
FT	#HET	68	 252 	HIS	A	1	601 	ZN	A	S	1
FT	#HET	68	 252 	HIS	A	3	603 	9Q9	A	S	2
FT	#HET	72	 256 	HIS	A	1	601 	ZN	A	S	3
FT	#HET	108	 292 	HIS	A	1	601 	ZN	A	S	3
FT	#HET	109	 293 	ASP	A	1	601 	ZN	A	S	3
FT	#HET	109	 293 	ASP	A	2	602 	MG	A	S	3
FT	#HET	138	 322 	GLU	A	2	602 	MG	A	S	1
FT	#HET	181	 365 	MET	A	3	603 	9Q9	A	S	2
FT	#HET	218	 402 	ASP	A	1	601 	ZN	A	S	3
FT	#HET	219	 403 	ILE	A	3	603 	9Q9	A	S	2
FT	#HET	236	 420 	LEU	A	3	603 	9Q9	A	S	5
FT	#HET	240	 424 	TYR	A	3	603 	9Q9	A	S	4
FT	#HET	257	 441 	PHE	A	3	603 	9Q9	A	S	1
FT	#HET	268	 452 	ALA	A	3	603 	9Q9	A	A	9
FT	#HET	269	 453 	GLN	A	3	603 	9Q9	A	S	10
FT	#HET	272	 456 	PHE	A	3	603 	9Q9	A	S	26
CC	SEQUENCE	322 AA (ATOM);
CC	KYLLSPETIE ALRKPTFDVW LWEPNEMLSC LEHMYHDLGL VRDFSINPVT LRRWLFCVHD
CC	NYRNNPFHNF RHCFCVAQMM YSMVWLCSLQ EKFSQTDILI LMTAAICHDL DHPGYNNTYQ
CC	INARTELAVR YNDISPLENH HCAVAFQILA EPECNIFSNI PPDGFKQIRQ GMITLILATD
CC	MARHAEIMDS FKEKMENFDY SNEEHMTLLK MILIKCCDIS NEVRPMEVAE PWVDCLLEEY
CC	FMQSDREKSE GLPVAPFMDR DKVTKATAQI GFIKFVLIPM FETVTKLFPM VEEIMLQPLW
CC	ESRDRYEELK RIDDAMKELQ KK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVT
CC	ATOM   KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVT
CC	       **************************************************
CC	SEQRES LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILI
CC	ATOM   LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILI
CC	       **************************************************
CC	SEQRES LMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILA
CC	ATOM   LMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILA
CC	       **************************************************
CC	SEQRES EPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDY
CC	ATOM   EPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDY
CC	       **************************************************
CC	SEQRES SNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE
CC	ATOM   SNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE
CC	       **************************************************
CC	SEQRES GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLW
CC	ATOM   GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLW
CC	       **************************************************
CC	SEQRES ESRDRYEELKRIDDAMKELQKK
CC	ATOM   ESRDRYEELKRIDDAMKELQKK
CC	       **********************
SQ	SEQUENCE	322 AA;      MW;         CN;
	KYLLSPETIE ALRKPTFDVW LWEPNEMLSC LEHMYHDLGL VRDFSINPVT LRRWLFCVHD
	NYRNNPFHNF RHCFCVAQMM YSMVWLCSLQ EKFSQTDILI LMTAAICHDL DHPGYNNTYQ
	INARTELAVR YNDISPLENH HCAVAFQILA EPECNIFSNI PPDGFKQIRQ GMITLILATD
	MARHAEIMDS FKEKMENFDY SNEEHMTLLK MILIKCCDIS NEVRPMEVAE PWVDCLLEEY
	FMQSDREKSE GLPVAPFMDR DKVTKATAQI GFIKFVLIPM FETVTKLFPM VEEIMLQPLW
	ESRDRYEELK RIDDAMKELQ KK
//
ID	6A3NB	STANDARD;	PRT;	322	AA.
DT	CONVERTED FROM PDB (SEQRES) 6A3N
DE	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.600
CC	R-Factor	0.249
FT	#SUB	124	 308 	ARG	B	165	 349 	PHE	A	Protein	S	8
FT	#SUB	128	 312 	ALA	B	169	 353 	ARG	A	Protein	B	2
FT	#SUB	129	 313 	VAL	B	143	 327 	ALA	A	Protein	B	2
FT	#SUB	129	 313 	VAL	B	147	 331 	GLN	A	Protein	S	1
FT	#SUB	129	 313 	VAL	B	169	 353 	ARG	A	Protein	B	1
FT	#SUB	130	 314 	ARG	B	130	 314 	ARG	A	Protein	S	1
FT	#SUB	130	 314 	ARG	B	131	 315 	TYR	A	Protein	A	5
FT	#SUB	130	 314 	ARG	B	143	 327 	ALA	A	Protein	B	1
FT	#SUB	131	 315 	TYR	B	130	 314 	ARG	A	Protein	S	5
FT	#SUB	131	 315 	TYR	B	131	 315 	TYR	A	Protein	S	4
FT	#SUB	132	 316 	ASN	B	139	 323 	ASN	A	Protein	S	8
FT	#SUB	132	 316 	ASN	B	142	 326 	CYS	A	Protein	S	4
FT	#SUB	132	 316 	ASN	B	143	 327 	ALA	A	Protein	S	2
FT	#SUB	132	 316 	ASN	B	169	 353 	ARG	A	Protein	B	2
FT	#SUB	132	 316 	ASN	B	173	 357 	ILE	A	Protein	B	1
FT	#SUB	133	 317 	ASP	B	169	 353 	ARG	A	Protein	A	12
FT	#SUB	134	 318 	ILE	B	177	 361 	LEU	A	Protein	S	1
FT	#SUB	139	 323 	ASN	B	132	 316 	ASN	A	Protein	A	9
FT	#SUB	142	 326 	CYS	B	132	 316 	ASN	A	Protein	A	4
FT	#SUB	143	 327 	ALA	B	129	 313 	VAL	A	Protein	A	3
FT	#SUB	143	 327 	ALA	B	130	 314 	ARG	A	Protein	S	1
FT	#SUB	143	 327 	ALA	B	132	 316 	ASN	A	Protein	B	2
FT	#SUB	147	 331 	GLN	B	129	 313 	VAL	A	Protein	S	1
FT	#SUB	165	 349 	PHE	B	124	 308 	ARG	A	Protein	S	6
FT	#SUB	169	 353 	ARG	B	128	 312 	ALA	A	Protein	S	2
FT	#SUB	169	 353 	ARG	B	129	 313 	VAL	A	Protein	S	1
FT	#SUB	169	 353 	ARG	B	132	 316 	ASN	A	Protein	S	2
FT	#SUB	169	 353 	ARG	B	133	 317 	ASP	A	Protein	S	11
FT	#SUB	173	 357 	ILE	B	132	 316 	ASN	A	Protein	S	4
FT	#SUB	177	 361 	LEU	B	134	 318 	ILE	A	Protein	S	1
FT	#HET	68	 252 	HIS	B	6	603 	9Q9	B	S	1
FT	#HET	72	 256 	HIS	B	4	601 	ZN	B	S	3
FT	#HET	108	 292 	HIS	B	4	601 	ZN	B	S	3
FT	#HET	109	 293 	ASP	B	4	601 	ZN	B	S	3
FT	#HET	109	 293 	ASP	B	5	602 	MG	B	S	3
FT	#HET	138	 322 	GLU	B	5	602 	MG	B	S	1
FT	#HET	181	 365 	MET	B	6	603 	9Q9	B	S	3
FT	#HET	218	 402 	ASP	B	4	601 	ZN	B	S	3
FT	#HET	219	 403 	ILE	B	6	603 	9Q9	B	S	1
FT	#HET	236	 420 	LEU	B	6	603 	9Q9	B	S	5
FT	#HET	240	 424 	TYR	B	6	603 	9Q9	B	S	3
FT	#HET	257	 441 	PHE	B	6	603 	9Q9	B	S	3
FT	#HET	268	 452 	ALA	B	6	603 	9Q9	B	A	7
FT	#HET	269	 453 	GLN	B	6	603 	9Q9	B	S	10
FT	#HET	272	 456 	PHE	B	6	603 	9Q9	B	S	33
CC	SEQUENCE	322 AA (ATOM);
CC	KYLLSPETIE ALRKPTFDVW LWEPNEMLSC LEHMYHDLGL VRDFSINPVT LRRWLFCVHD
CC	NYRNNPFHNF RHCFCVAQMM YSMVWLCSLQ EKFSQTDILI LMTAAICHDL DHPGYNNTYQ
CC	INARTELAVR YNDISPLENH HCAVAFQILA EPECNIFSNI PPDGFKQIRQ GMITLILATD
CC	MARHAEIMDS FKEKMENFDY SNEEHMTLLK MILIKCCDIS NEVRPMEVAE PWVDCLLEEY
CC	FMQSDREKSE GLPVAPFMDR DKVTKATAQI GFIKFVLIPM FETVTKLFPM VEEIMLQPLW
CC	ESRDRYEELK RIDDAMKELQ KK
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVT
CC	ATOM   KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVT
CC	       **************************************************
CC	SEQRES LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILI
CC	ATOM   LRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILI
CC	       **************************************************
CC	SEQRES LMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILA
CC	ATOM   LMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILA
CC	       **************************************************
CC	SEQRES EPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDY
CC	ATOM   EPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDY
CC	       **************************************************
CC	SEQRES SNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE
CC	ATOM   SNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSE
CC	       **************************************************
CC	SEQRES GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLW
CC	ATOM   GLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLW
CC	       **************************************************
CC	SEQRES ESRDRYEELKRIDDAMKELQKK
CC	ATOM   ESRDRYEELKRIDDAMKELQKK
CC	       **********************
SQ	SEQUENCE	322 AA;      MW;         CN;
	KYLLSPETIE ALRKPTFDVW LWEPNEMLSC LEHMYHDLGL VRDFSINPVT LRRWLFCVHD
	NYRNNPFHNF RHCFCVAQMM YSMVWLCSLQ EKFSQTDILI LMTAAICHDL DHPGYNNTYQ
	INARTELAVR YNDISPLENH HCAVAFQILA EPECNIFSNI PPDGFKQIRQ GMITLILATD
	MARHAEIMDS FKEKMENFDY SNEEHMTLLK MILIKCCDIS NEVRPMEVAE PWVDCLLEEY
	FMQSDREKSE GLPVAPFMDR DKVTKATAQI GFIKFVLIPM FETVTKLFPM VEEIMLQPLW
	ESRDRYEELK RIDDAMKELQ KK
//